INT173851

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Context Info
Confidence 0.76
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 13.95
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (FN1) extracellular region (FN1) cell adhesion (FN1)
proteinaceous extracellular matrix (FN1)
Anatomy Link Frequency
nucleus 2
endothelial cell 2
plasma 1
fibroblast 1
eosinophil 1
FN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 118 99.10 Very High Very High Very High
metalloproteinase 32 99.08 Very High Very High Very High
Chronic pancreatitis 161 96.72 Very High Very High Very High
Inflammation 190 95.12 Very High Very High Very High
chemokine 23 79.80 Quite High
Osteoarthritis 75 77.04 Quite High
Endocannabinoid 48 77.04 Quite High
fibrosis 59 75.00 Quite High
antagonist 51 69.80 Quite High
Inflammatory mediators 8 57.36 Quite High
Disease Link Frequency Relevance Heat
Boutonneuse Fever 164 100.00 Very High Very High Very High
Myocardial Infarction 118 100.00 Very High Very High Very High
Neutropenia 73 100.00 Very High Very High Very High
Alzheimer's Dementia 2 100.00 Very High Very High Very High
Adhesions 86 99.92 Very High Very High Very High
Primary Sclerosing Cholangitis 319 99.84 Very High Very High Very High
Meningitis 40 99.84 Very High Very High Very High
Injury 37 99.52 Very High Very High Very High
Wound Healing 4 98.88 Very High Very High Very High
Cancer 229 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both the secreted FN1 and PAI1 functions to enhance cell attachment and normal cell growth [20].
Localization (secreted) of FN1
1) Confidence 0.76 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.41 Pain Relevance 0
Since FN1 does not belong to the family of known biomarkers of HF and is released in the plasma following injury, it will certainly be interesting to determine its prognostic performance and therapeutic utility in the context of HF.
Localization (released) of FN1 in plasma associated with injury and myocardial infarction
2) Confidence 0.74 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2890499 Disease Relevance 1.64 Pain Relevance 0.07
At present, we know that MSF is at least as severe as RMSF and has a mortality rate as high as 32.3%, which occurred in Portugal in 1997 (4).
Localization (severe) of MSF associated with meningitis and boutonneuse fever
3) Confidence 0.71 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2603122 Disease Relevance 1.60 Pain Relevance 0
The first hypothesis could be that severe forms of MSF were not well recognized in the past.
Localization (forms) of MSF associated with boutonneuse fever
4) Confidence 0.58 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2603122 Disease Relevance 1.45 Pain Relevance 0
G3 effects on endothelial cell migration with and without the presences of VEGF and fibronectin
Localization (presences) of fibronectin in endothelial cell
5) Confidence 0.29 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.40 Pain Relevance 0
Furthermore, AM215 had no effects on fibronectin and collagen 1 secretion (cell culture supernatants of cells grown to 100% confluency before initiation of treatment; immunoblots from three pooled experiments; Figure 4).
Localization (secretion) of fibronectin
6) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.41 Pain Relevance 0.23
In a next step, the profibrogenic cytokine TGFbeta, which stimulates the synthesis and secretion of fibronectin, collagen1 and matrix metalloproteinases, was analyzed, revealing that neither AM251 nor AM630 significantly altered secreted TGFbeta levels (Figure 3E).
Localization (secretion) of fibronectin associated with metalloproteinase and cytokine
7) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.57 Pain Relevance 0.28
These experiments showed that both LPS and TNFalpha increased the secretion of collagen1 and fibronectin (Figure 3A).
Localization (secretion) of fibronectin
8) Confidence 0.24 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.51 Pain Relevance 0.04
Immunoblot analysis of cell culture supernatants was used to analyze the secretion of the extracellular matrix proteins collagen1 and fibronectin by PSC.
Spec (analyze) Localization (secretion) of fibronectin in extracellular matrix associated with primary sclerosing cholangitis
9) Confidence 0.24 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.68 Pain Relevance 0.07
Coculture experiments with PSC and PBMC revealed increased fibronectin secretion induced by PBMC.
Localization (secretion) of fibronectin associated with primary sclerosing cholangitis
10) Confidence 0.21 Published 2007 Journal J Transl Med Section Abstract Doc Link PMC2234395 Disease Relevance 1.59 Pain Relevance 0.86
In 1997, eEPCs were the first putative endothelial progenitors isolated in vitro by culturing CD34+ VEGFR2+ mononuclear blood cells on fibronectin [25] and confirming a subsequent increase in expression of endothelial cell-associated markers such as CD34, CD31, VEGFR2, Tie2, and E-selectin.
Localization (blood cells) of fibronectin in endothelial cell
11) Confidence 0.12 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0.18 Pain Relevance 0.05
305) patients undergoing chemotherapy found that first-cycle FN, age ?
Localization (age) of FN associated with neutropenia
12) Confidence 0.11 Published 2010 Journal Support Care Cancer Section Body Doc Link PMC2846279 Disease Relevance 0.87 Pain Relevance 0
Based on these findings, it was concluded that human plasma fibronectin was immobilized at the surface, and significantly promoted fibroblast spreading, suggesting that this chemical modification offers an effective means of controlling metal/cell interactions [140].
Localization (immobilized) of fibronectin in fibroblast
13) Confidence 0.09 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2871132 Disease Relevance 0 Pain Relevance 0
At immunohistochemistry, we detected the location of type I and II collagen, S-100 protein, and fibronectin.
Localization (location) of fibronectin
14) Confidence 0.05 Published 2010 Journal Strategies Trauma Limb Reconstr Section Body Doc Link PMC2918740 Disease Relevance 0 Pain Relevance 0
Fibroblast destruction leads to generation of fibronectin, which is responsible for a breakdown in connective tissue and the release of metalloproteinases responsible for more apoptosis.
Localization (generation) of fibronectin in connective tissue associated with metalloproteinase and apoptosis
15) Confidence 0.04 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661654 Disease Relevance 0.73 Pain Relevance 0.09
We selected Fibronectin (FN-1), a gene involved in wound healing, blood coagulation, and cancer metastasis [46], as a representative candidate that showed significantly different expression in hemangiosarcoma and splenic hematoma, but did not meet the initial FDR criteria.
Localization (selected) of Fibronectin in blood associated with hematoma, cancer, wound healing, hemangiosarcoma and metastasis
16) Confidence 0.04 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2994824 Disease Relevance 1.33 Pain Relevance 0
Additionally, several collagen types such as III, V, VI, IX, X, XI, XII, and XIV, small proteoglycans, such as lumican, biglycan, decorin and fibromodulin, and other glycoproteins, such as fibronectin and amyloid comprise the nucleus [22, 23].
Localization (several) of fibronectin in nucleus associated with alzheimer's dementia
17) Confidence 0.04 Published 2007 Journal Curr Rev Musculoskelet Med Section Body Doc Link PMC2684219 Disease Relevance 0.18 Pain Relevance 0.03
Additionally, several collagen types such as III, V, VI, IX, X, XI, XII, and XIV, small proteoglycans, such as lumican, biglycan, decorin and fibromodulin, and other glycoproteins, such as fibronectin and amyloid comprise the nucleus [22, 23].
Localization (comprise) of fibronectin in nucleus associated with alzheimer's dementia
18) Confidence 0.04 Published 2007 Journal Curr Rev Musculoskelet Med Section Body Doc Link PMC2684219 Disease Relevance 0.18 Pain Relevance 0
This protective effect was associated with its coating of the articular surface, suppression of fibronectin-fragment-enhanced stromelysin-1 release, increased PG synthesis, and restoration of PGs in damaged cartilage [65].
Localization (release) of fibronectin in articular
19) Confidence 0.03 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165033 Disease Relevance 0.24 Pain Relevance 0.19
Conclusions: Cdk5 is an important intracellular regulator of eosinophil adhesion to fibronectin and EPO secretion.
Localization (secretion) of fibronectin in eosinophil associated with adhesions
20) Confidence 0.03 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.52 Pain Relevance 0.04

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