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Context Info
Confidence 0.64
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.65
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ACAN) cell adhesion (ACAN) proteinaceous extracellular matrix (ACAN)
Anatomy Link Frequency
cartilage 1
body 1
ACAN (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 104 95.60 Very High Very High Very High
Osteoarthritis 104 93.28 High High
metalloproteinase 52 90.20 High High
cytokine 37 86.88 High High
rheumatoid arthritis 16 84.16 Quite High
spinal inflammation 1 83.60 Quite High
nociceptor 2 51.56 Quite High
Inflammation 20 50.16 Quite High
chemokine 1 22.24 Low Low
Antinociceptive 2 20.52 Low Low
Disease Link Frequency Relevance Heat
Juvenile Chronic Polyarthritis 90 95.60 Very High Very High Very High
Knee Osteoarthritis 67 93.28 High High
Stress 8 93.28 High High
Rheumatoid Arthritis 16 84.16 Quite High
Low Back Pain 1 83.60 Quite High
Cancer 4 81.04 Quite High
Necrosis 4 80.56 Quite High
Disease Progression 3 58.56 Quite High
Osteoarthritis 42 57.40 Quite High
INFLAMMATION 27 50.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aggrecan is cleaved by aggrecanases, leading to its degradation and to subsequent erosion of cartilage [34,35].
Protein_catabolism (degradation) of aggrecan in cartilage
1) Confidence 0.64 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165033 Disease Relevance 0.73 Pain Relevance 0.48
Effects of tonicity on promoter activity and mRNA stability of AGC1 are incompletely understood.
Protein_catabolism (stability) of AGC1
2) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.22 Pain Relevance 0
Degradation products of aggrecan can be detected in body fluids, including synovial fluid, where they reflect aggrecan turnover [38,39].
Protein_catabolism (Degradation) of aggrecan in body
3) Confidence 0.07 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794523 Disease Relevance 0.70 Pain Relevance 0.53

General Comments

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