INT17386

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Context Info
Confidence 0.38
First Reported 1991
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 30.89
Pain Relevance 20.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
knee joint 4
neurons 3
plasma 1
tail 1
articular 1
Aia1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 2300 100.00 Very High Very High Very High
bradykinin 1484 100.00 Very High Very High Very High
substance P 1473 100.00 Very High Very High Very High
rheumatoid arthritis 158 100.00 Very High Very High Very High
Lasting pain 31 99.84 Very High Very High Very High
Inflammation 1322 99.76 Very High Very High Very High
Pain 590 98.64 Very High Very High Very High
Hyperalgesia 314 98.48 Very High Very High Very High
b2 receptor 56 96.68 Very High Very High Very High
anesthesia 5 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arthritis 2676 100.00 Very High Very High Very High
Rheumatoid Arthritis 160 100.00 Very High Very High Very High
Disease 135 100.00 Very High Very High Very High
Pain 550 99.84 Very High Very High Very High
INFLAMMATION 1270 99.76 Very High Very High Very High
Pressure And Volume Under Development 163 98.80 Very High Very High Very High
Hyperalgesia 319 98.48 Very High Very High Very High
Nociception 277 98.24 Very High Very High Very High
Immunization 69 95.76 Very High Very High Very High
Hyperplasia 65 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Parallel time courses of clinical and behavioural parameters and levels of plasma substance P-like immunoreactivity (SPLI-PI) were studied in arthritic rats (adjuvant induced arthritis, AIA, a chronic pain model).
Positive_regulation (induced) of AIA in plasma associated with lasting pain, arthritis and substance p
1) Confidence 0.38 Published 1991 Journal C. R. Acad. Sci. III, Sci. Vie Section Abstract Doc Link 1905187 Disease Relevance 0.61 Pain Relevance 0.43
Groups of rats were killed at different time points after the induction of AIA, and inflammation and destruction in the knee joint were graded by histological examination.
Positive_regulation (induction) of AIA in knee joint associated with inflammation and arthritis
2) Confidence 0.22 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17819 Disease Relevance 1.92 Pain Relevance 0.91
At 84 days after the induction of AIA, 51.0 ± 12.7% of the neurons showed an expression of BK–gold-binding sites and this was close to the prearthritic values.
Positive_regulation (induction) of AIA in neurons associated with bradykinin and arthritis
3) Confidence 0.22 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 0.86 Pain Relevance 0.74
At 1–29 days after the induction of AIA, the rats showed signs of mechanical hyperalgesia in the leg with inflammation.
Positive_regulation (induction) of AIA in leg associated with hyperalgesia, inflammation and arthritis
4) Confidence 0.22 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 1.32 Pain Relevance 0.64
In 33 female Lewis rats 10 weeks old, AIA was induced in the right knee joint.
Positive_regulation (induced) of AIA in knee joint associated with arthritis
5) Confidence 0.22 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17819 Disease Relevance 2.05 Pain Relevance 0.99
At several time points after the induction of AIA, the behaviour of rats (at least n = 5 rats for each time point) was assessed by using a score.
Positive_regulation (induction) of AIA associated with arthritis
6) Confidence 0.22 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 0.65 Pain Relevance 0.24
At 84 days after the induction of AIA (n = 5 rats), 51.0 ± 12.7% of the neurons showed an expression of BK–gold-binding sites and this was close to the prearthritic values.
Positive_regulation (induction) of AIA in neurons associated with bradykinin and arthritis
7) Confidence 0.22 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17819 Disease Relevance 1.13 Pain Relevance 0.92
Receptor upregulation in the acute phase of AIA was bilateral and almost symmetrical.
Positive_regulation (upregulation) of AIA associated with arthritis
8) Confidence 0.22 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 0.94 Pain Relevance 1.29
The expression of SP-binding sites was upregulated only in the first days of AIA, that is, in the acute phase, in which the pain responses to mechanical stimulation were most pronounced.
Positive_regulation (upregulated) of AIA associated with pain, arthritis and substance p
9) Confidence 0.22 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17819 Disease Relevance 1.32 Pain Relevance 1.41
Figure 4 shows neurons that were isolated from DRGs L1–L5 3 days after the induction of AIA and then cultured.
Positive_regulation (induction) of AIA in neurons associated with arthritis
10) Confidence 0.22 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 0.72 Pain Relevance 0.81
Secondly, whereas the expression of SP-binding sites was upregulated only in the first days of AIA, that is, in the acute phase, the upregulation of BK-binding sites on the side of AIA persisted for up to 42 days.
Positive_regulation (upregulated) of AIA associated with bradykinin, arthritis and substance p
11) Confidence 0.16 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 1.24 Pain Relevance 1.39
In the later phases of AIA (10–84 days after induction of AIA) the joint showed persistent swelling, and signs of chronic arthritic alterations such as infiltration of mononuclear leucocytes, hyperplasia of synovial lining layer (pannus formation) and erosions of cartilage and bone were predominant.
Positive_regulation (induction) of AIA in leucocytes associated with pressure and volume under development, hyperplasia and arthritis
12) Confidence 0.15 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17819 Disease Relevance 1.32 Pain Relevance 1.07
Receptor upregulation in the acute phase of AIA was bilateral and almost symmetrical.
Positive_regulation (upregulation) of AIA associated with arthritis
13) Confidence 0.15 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17819 Disease Relevance 1.26 Pain Relevance 1.23
These results show that in AIA in the rat the expression of SP-binding and BK-binding sites in the perikarya of DRGs L1–L5 is markedly upregulated in the course of knee inflammation.
Positive_regulation (upregulated) of AIA in knee associated with inflammation, bradykinin, substance p and arthritis
14) Confidence 0.15 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17819 Disease Relevance 1.19 Pain Relevance 1.30
The inflammatory process in the injected right knee joint started on the first day after induction of AIA and persisted throughout the observation period of 84 days (Fig. 1).
Positive_regulation (induction) of AIA in knee joint associated with inflammation and arthritis
15) Confidence 0.15 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17819 Disease Relevance 1.38 Pain Relevance 1.17
In contrast, the deoxypyridinoline/creatinine urinary level remained stable in normal controls but increased significantly in AIA controls.
Positive_regulation (increased) of AIA associated with arthritis
16) Confidence 0.09 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 1.11 Pain Relevance 0.20
AIA was induced in Lewis rats by a subcutaneous injection of 1 mg of complete Freund's adjuvant.
Positive_regulation (induced) of AIA associated with arthritis
17) Confidence 0.09 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2374462 Disease Relevance 0.86 Pain Relevance 0.36
The most suitable RMIA for preclinical development are the induced diseases that have been proven to predict the responsiveness of human RA patients: AIA, CIA, and SCW [37, 153] (Table 2).
Positive_regulation (induced) of AIA associated with rheumatoid arthritis, disease and arthritis
18) Confidence 0.08 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3022224 Disease Relevance 2.08 Pain Relevance 0.78
This dependence is shown by the ability to pass rat AIA [11, 108, 109] as well as rat [110] and mouse [111] CIA to nonimmunized (naive) recipients by transferring sensitized T-cells from affected donors and by the inability to induce AIA [27] or SCW [112] in athymic rats.
Positive_regulation (induce) of AIA in T-cells associated with addiction and arthritis
19) Confidence 0.08 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3022224 Disease Relevance 1.43 Pain Relevance 0.65
Adjuvant-induced arthritis (AIA) was obtained in 6-week-old animals by s.c. injection at the base of the tail of 300 ?
Positive_regulation (induced) of AIA in tail associated with arthritis
20) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374451 Disease Relevance 0.51 Pain Relevance 0.20

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