INT17387

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Context Info
Confidence 0.50
First Reported 1991
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.40
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gnaz) signal transduction (Gnaz) plasma membrane (Gnaz)
GTPase activity (Gnaz) signal transducer activity (Gnaz)
Anatomy Link Frequency
hypothalamus 1
liver 1
Gnaz (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 20 99.74 Very High Very High Very High
Clonidine 1 89.60 High High
agonist 2 87.08 High High
antagonist 1 75.00 Quite High
Raphe 1 57.60 Quite High
sSRI 1 34.80 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 5 98.48 Very High Very High Very High
Bordatella Infection 1 65.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The function but not the expression of rat liver inhibitory guanine nucleotide binding protein is altered in streptozotocin-induced diabetes.
Gene_expression (expression) of guanine nucleotide binding protein in liver associated with diabetes mellitus
1) Confidence 0.50 Published 1991 Journal Endocrinology Section Title Doc Link 1905225 Disease Relevance 0.40 Pain Relevance 0.09
Although previous studies indicate that injections of fluoxetine for 14 days produce a reduction of Gz protein levels in the hypothalamus, the levels of Gz proteins were not affected by either fluoxetine or WAY-100635.
Gene_expression (produce) of Gz protein in hypothalamus associated with fluoxetine
2) Confidence 0.06 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10871325 Disease Relevance 0 Pain Relevance 0.74
Hypothalamic levels of Gz protein were reduced by both the 7.5 and 10 mg/kg/day doses of fluoxetine, whereas Gi1 protein levels were reduced only after the highest dose (10 mg/kg/day) of fluoxetine.
Gene_expression (levels) of Gz protein associated with fluoxetine
3) Confidence 0.04 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9862759 Disease Relevance 0 Pain Relevance 0.98

General Comments

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