INT173876

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Context Info
Confidence 0.25
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.57
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL7A1) cell adhesion (COL7A1)
Anatomy Link Frequency
tunica albuginea 2
extracellular matrix 2
COL7A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 1 100.00 Very High Very High Very High
metalloproteinase 10 94.84 High High
corticosteroid 11 5.00 Very Low Very Low Very Low
backache 11 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
vincristine 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
methotrexate 5 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Intervertebral Disk Degeneration 44 98.60 Very High Very High Very High
Wound Healing 107 93.84 High High
Reprotox - General 2 53 93.32 High High
Injury 103 88.84 High High
Aging 7 88.84 High High
Scurvy 1 85.64 High High
Disease 21 76.40 Quite High
Cancer 79 66.44 Quite High
Appetite Loss 10 57.24 Quite High
Postoperative Complications 3 53.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vitamin C is necessary for hydroxylation of proline and lysine residues in collagen polymerization and cross-linking.105 Hydroxyproline is essential for the helical stability of collagen and its subsequent secretion into the extracellular matrix, while hydroxylysine is required for collagen cross-linking and further polymerization of fibers.2 In the absence of vitamin C, collagen formation is poor, and the unhydroxylated protein is susceptible to proteolysis.135 This leads to weakness of the extracellular matrix and the clinical condition scurvy, manifested by abnormal wound healing.2
Positive_regulation (essential) of Positive_regulation (stability) of collagen in extracellular matrix associated with scurvy and wound healing
1) Confidence 0.25 Published 2008 Journal Eplasty Section Body Doc Link PMC2206003 Disease Relevance 0.85 Pain Relevance 0
The biochemistry of disc degeneration indicates that enzymatic activity contributes to this disorder, with increased fragmentation of the collagen, proteoglycan and fibronectin populations.
Positive_regulation (increased) of Positive_regulation (fragmentation) of collagen associated with intervertebral disk degeneration
2) Confidence 0.15 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165040 Disease Relevance 0.32 Pain Relevance 0.19
Systemic changes and alterations in the structure and function of the penis in elderly men include hormonal changes (mainly testosterone decrease and increase in sex hormone binding globulin that resulting decreased bioavailability of testosterone) (Margolese 2000), decrease in elastic fibers and increase in collagen fibers in the tunica albuginea (Akkus et al 1997) and molecular changes (decrease in nitric oxide synthase) (Andrew and Mayer 1999).
Positive_regulation (increase) of Positive_regulation (increase) of collagen in tunica albuginea associated with bioavailability
3) Confidence 0.03 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699643 Disease Relevance 0.40 Pain Relevance 0.05

General Comments

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