INT17389

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Context Info
Confidence 0.58
First Reported 1991
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.99
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
neurons 4
spinal 2
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
noradrenaline 11 100.00 Very High Very High Very High
Raphe magnus 7 100.00 Very High Very High Very High
Opioid 3 100.00 Very High Very High Very High
Clonidine 14 99.98 Very High Very High Very High
Dorsal horn neuron 1 99.92 Very High Very High Very High
Pain 4 98.52 Very High Very High Very High
substance P 5 98.20 Very High Very High Very High
spinal dorsal horn 3 95.36 Very High Very High Very High
Substantia nigra 6 93.44 High High
Kinase C 2 91.20 High High
Disease Link Frequency Relevance Heat
Bordatella Infection 5 100.00 Very High Very High Very High
Pain 3 98.52 Very High Very High Very High
Diabetes Mellitus 5 98.16 Very High Very High Very High
Nociception 2 89.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the activation of alpha 2 adrenoceptor coupled with IAP-sensitive GTP binding protein decreases the intracellular cyclic AMP and cyclic AMP-dependent protein kinase activity, thus resulting in the potentiation of glycine receptor-mediated taurine response in rat SN neurons.
Negative_regulation (decreases) of Positive_regulation (activation) of alpha 2 adrenoceptor in neurons associated with substantia nigra
1) Confidence 0.58 Published 1996 Journal J. Neurophysiol. Section Abstract Doc Link 8899617 Disease Relevance 0.09 Pain Relevance 0.13
Activation of alpha2-adrenoceptor down-regulates the activity of protein kinase A that results in the potentiation of the glycinergic inhibitory effects within the spinal dorsal horn.
Negative_regulation (down-regulates) of Positive_regulation (Activation) of alpha2-adrenoceptor in spinal associated with spinal dorsal horn
2) Confidence 0.43 Published 2003 Journal Life Sci. Section Abstract Doc Link 12798415 Disease Relevance 0 Pain Relevance 0.33
We conclude that activation and inhibition of alpha2-adrenergic receptors of NRM neurons augments and suppresses output of the descending inhibitory pain pathway.
Negative_regulation (suppresses) of Positive_regulation (activation) of alpha2-adrenergic in neurons associated with pain and raphe magnus
3) Confidence 0.33 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 9972774 Disease Relevance 0.24 Pain Relevance 1.32
Clonidine activation of the alpha 2 adrenergic receptor, which activates Gi, inhibited forskolin--stimulated adenylate cyclase activity in control membranes.
Negative_regulation (inhibited) of Positive_regulation (activation) of alpha 2 adrenergic receptor associated with clonidine
4) Confidence 0.30 Published 1991 Journal Endocrinology Section Abstract Doc Link 1905225 Disease Relevance 0.37 Pain Relevance 0.10
These results suggest that the activation of alpha2-adrenoceptor by noradrenaline coupled with pertussis toxin-sensitive G-proteins reduces intracellular cyclic AMP formation through the inhibition of adenyl cyclase.
Negative_regulation (reduces) of Positive_regulation (activation) of alpha2-adrenoceptor associated with bordatella infection and noradrenaline
5) Confidence 0.20 Published 1999 Journal Neuroscience Section Abstract Doc Link 10051215 Disease Relevance 0.19 Pain Relevance 0.56
In PTX-treated slices the frequency decrease due to GABAB, mu-opioid, and alpha 2-adrenergic receptor activation was attenuated (P < or = 0.05), whereas the SP receptor-mediated response was unaltered.
Negative_regulation (decrease) of Positive_regulation (activation) of alpha 2-adrenergic associated with opioid and substance p
6) Confidence 0.20 Published 1996 Journal J. Appl. Physiol. Section Abstract Doc Link 8806921 Disease Relevance 0.09 Pain Relevance 0.62

General Comments

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