INT173891

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.00
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 37 99.08 Very High Very High Very High
Inflammation 28 98.16 Very High Very High Very High
Arthritis 21 80.88 Quite High
ischemia 14 79.00 Quite High
anesthesia 4 34.84 Quite Low
antagonist 10 5.00 Very Low Very Low Very Low
Glutamate 8 5.00 Very Low Very Low Very Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Osteoarthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 29 98.16 Very High Very High Very High
Cancer 57 94.80 High High
Necrosis 1 94.32 High High
Apoptosis 16 90.96 High High
Breast Cancer 53 83.84 Quite High
Arthritis 30 80.88 Quite High
Pancreatic Cancer 1 79.28 Quite High
Cv Unclassified Under Development 12 79.00 Quite High
Hypoxia 20 78.64 Quite High
Colorectal Cancer 50 64.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that elevated serum levels of TGF-?
Positive_regulation (elevated) of Phosphorylation (levels) of TGF
1) Confidence 0.49 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0.44 Pain Relevance 0.12
, TGFB1 binds to TGFBR2 which then leads to recruitment via phosphorylation of the type I TGF- ?
Positive_regulation (leads) of Phosphorylation (phosphorylation) of TGF
2) Confidence 0.26 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.67 Pain Relevance 0
TGFß1-induced Smad 2/3 phosphorylation and the combination of EGF, LIF and TGFß1 synergistically increased STAT3 phosphorylation over single or double cytokine combinations.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of TGF associated with cytokine
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2832687 Disease Relevance 0.28 Pain Relevance 0.23
TGFß1-induced Smad 2/3 phosphorylation and the combination of EGF, LIF and TGFß1 synergistically increased STAT3 phosphorylation over single or double cytokine combinations.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of TGF associated with cytokine
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2832687 Disease Relevance 0.27 Pain Relevance 0.23
mol/l genistein induced a fivefold increase in the level of TGF-?
Positive_regulation (increase) of Phosphorylation (level) of TGF
5) Confidence 0.05 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 0.33 Pain Relevance 0

General Comments

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