INT173892

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Context Info
Confidence 0.79
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.63
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)
Anatomy Link Frequency
astrocyte 1
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 75 99.08 Very High Very High Very High
Inflammation 32 98.16 Very High Very High Very High
aspirin 100 95.80 Very High Very High Very High
Arthritis 21 80.88 Quite High
ischemia 28 79.24 Quite High
addiction 1 66.64 Quite High
antagonist 20 43.68 Quite Low
anesthesia 8 35.08 Quite Low
Glutamate 16 28.96 Quite Low
ketamine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 40 98.16 Very High Very High Very High
Apoptosis 25 97.28 Very High Very High Very High
Cancer 58 94.80 High High
Necrosis 2 94.32 High High
Breast Cancer 53 83.20 Quite High
Arthritis 30 80.88 Quite High
Cv Unclassified Under Development 24 79.24 Quite High
Hypoxia 40 78.88 Quite High
Pancreatic Cancer 1 78.28 Quite High
Colorectal Cancer 50 63.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that elevated serum levels of TGF-?
Phosphorylation (levels) of TGF
1) Confidence 0.79 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0.44 Pain Relevance 0.12
Of note, this concentration of TGF-?
Phosphorylation (concentration) of TGF
2) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.29 Pain Relevance 0.48
, TGFB1 binds to TGFBR2 which then leads to recruitment via phosphorylation of the type I TGF- ?
Phosphorylation (phosphorylation) of TGF
3) Confidence 0.45 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.61 Pain Relevance 0
We hypothesized that TGFß1 would act though ALK1 to induce astrocyte specification; however, TGFß1 only increased Smad 2/3 phosphorylation, reflecting signaling though ALK5 instead of ALK1.
Phosphorylation (phosphorylation) of TGF in astrocyte
4) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0.12 Pain Relevance 0
TGFß1-induced Smad 2/3 phosphorylation and the combination of EGF, LIF and TGFß1 synergistically increased STAT3 phosphorylation over single or double cytokine combinations.
Phosphorylation (phosphorylation) of TGF associated with cytokine
5) Confidence 0.09 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2832687 Disease Relevance 0.28 Pain Relevance 0.23
TGFß1-induced Smad 2/3 phosphorylation and the combination of EGF, LIF and TGFß1 synergistically increased STAT3 phosphorylation over single or double cytokine combinations.
Phosphorylation (phosphorylation) of TGF associated with cytokine
6) Confidence 0.09 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2832687 Disease Relevance 0.27 Pain Relevance 0.23
TGFß1-induced Smad 2/3 phosphorylation and the combination of EGF, LIF and TGFß1 synergistically increased STAT3 phosphorylation over single or double cytokine combinations.
Phosphorylation (phosphorylation) of TGF associated with cytokine
7) Confidence 0.09 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2832687 Disease Relevance 0.29 Pain Relevance 0.23
mol/l genistein induced a fivefold increase in the level of TGF-?
Phosphorylation (level) of TGF
8) Confidence 0.08 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 0.33 Pain Relevance 0

General Comments

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