INT17391

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Context Info
Confidence 0.75
First Reported 1989
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 5.26
Pain Relevance 4.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (GNAI1) GTPase activity (GNAI1) cytoplasm (GNAI1)
signal transducer activity (GNAI1) signal transduction (GNAI1) nucleus (GNAI1)
Anatomy Link Frequency
lymphocytes 2
upper 2
smooth muscle 1
liver 1
neurons 1
GNAI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 2 99.32 Very High Very High Very High
opioid receptor 10 99.00 Very High Very High Very High
headache 5 98.52 Very High Very High Very High
Neuritis 1 98.30 Very High Very High Very High
Migraine 10 98.08 Very High Very High Very High
Opioid 67 97.84 Very High Very High Very High
agonist 46 97.76 Very High Very High Very High
narcan 10 97.44 Very High Very High Very High
Cluster headache 6 96.24 Very High Very High Very High
Osteoarthritis 22 94.88 High High
Disease Link Frequency Relevance Heat
Weight Loss 2 99.62 Very High Very High Very High
Abdominal Pain 2 99.32 Very High Very High Very High
Ulcers 13 99.28 Very High Very High Very High
Diabetes Mellitus 10 99.06 Very High Very High Very High
Headache 11 98.52 Very High Very High Very High
Neuritis 1 98.30 Very High Very High Very High
Migraine Without Aura 2 98.08 Very High Very High Very High
Hemorrhage 6 97.88 Very High Very High Very High
Pancreatic Cancer 5 97.32 Very High Very High Very High
Migraine With Aura 2 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The functionality, evaluated as capability to inhibit forskolin-stimulated adenylyl cyclase activity, and the level of expression of Gi proteins were investigated in peripheral blood lymphocytes.
Gene_expression (expression) of Gi in lymphocytes
1) Confidence 0.75 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11669173 Disease Relevance 0.09 Pain Relevance 0
The functionality and the level of expression of Gi proteins were investigated in lymphocytes from migraine without aura, migraine with aura and cluster headache sufferers.
Gene_expression (expression) of Gi in lymphocytes associated with cluster headache and migraine
2) Confidence 0.75 Published 2001 Journal Cephalalgia Section Abstract Doc Link 11298662 Disease Relevance 0.88 Pain Relevance 0.94
neurons exhibited increased neuritogenesis, extended neuritis and a two-fold increase in the number of branching points per neuron compared to wt neurons (Fig. 4g–i).
Gene_expression (neurons) of g-i in neurons associated with neuritis
3) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0.48 Pain Relevance 0.12
FPR is known to signal through Gi proteins stimulating phospholipase C leading to mobilization of Ca2+ from intracellular stores and to activation of PI3K [24].
Gene_expression (proteins) of Gi
4) Confidence 0.65 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.06 Pain Relevance 0.89
The reduced activity of Gi proteins seems not to be related to a reduction of protein levels since no significant reduction of the Gialpha subunits was observed.
Neg (no) Gene_expression (reduction) of Gi
5) Confidence 0.65 Published 2001 Journal Cephalalgia Section Abstract Doc Link 11298662 Disease Relevance 0.81 Pain Relevance 0.96
The prevalence of pancreatic cancer may be as high as about 15% in patients over 40 years old who have unexplained upper abdominal pain or weight loss and in whom upper G-I endoscopy is negative.
Neg (negative) Gene_expression (negative) of G-I in upper associated with abdominal pain, weight loss and pancreatic cancer
6) Confidence 0.58 Published 1999 Journal Ann. Oncol. Section Abstract Doc Link 10436801 Disease Relevance 0.50 Pain Relevance 0.26
Based on the GI risk profile at baseline, patients were excluded if they were on GI protection, had an upper GI ulcer during the last 3 months, GI bleeding last year or any history of perforation or obstruction (Table 1) (Schnitzer et al 2004).
Gene_expression (protection) of GI in upper associated with ulcers and hemorrhage
7) Confidence 0.06 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504080 Disease Relevance 0.86 Pain Relevance 0.26
Therefore, STZ-induced diabetes altered the function of Gi but had no effect on Gi expression.
Gene_expression (expression) of Gi associated with diabetes mellitus
8) Confidence 0.02 Published 1991 Journal Endocrinology Section Abstract Doc Link 1905225 Disease Relevance 0.50 Pain Relevance 0.07
Immunoblots using this antibody detect no difference between normal and STZ diabetic animals in the level of liver plasma membrane Gi expression.
Gene_expression (expression) of Gi in liver associated with diabetes mellitus
9) Confidence 0.02 Published 1991 Journal Endocrinology Section Abstract Doc Link 1905225 Disease Relevance 0.42 Pain Relevance 0.07
also increase Gi and Gq alpha protein expression in airway smooth muscle, which could account for increased Ca2+ responses and contraction [33,34].
Gene_expression (expression) of Gi in smooth muscle
10) Confidence 0.01 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.23 Pain Relevance 0.21
This indicates that the process of down-regulation and desensitization of the delta-opioid receptor neither requires quantitative alterations in the levels of Gi and Go nor changes in the degree of coupling among their subunits.
Gene_expression (levels) of Gi associated with opioid receptor
11) Confidence 0.01 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2507742 Disease Relevance 0.20 Pain Relevance 0.45
However, pretreatment for 72 h with naloxone increased the incorporation of ADP-ribose without an apparent change in affinity or in the immunochemically determined protein levels of Gi and Go.
Spec (determined) Gene_expression (levels) of Gi associated with narcan
12) Confidence 0.01 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2507742 Disease Relevance 0.22 Pain Relevance 0.47

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