INT173910

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 19.99
Pain Relevance 4.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LRP2) endosome (LRP2) small molecule metabolic process (LRP2)
Golgi apparatus (LRP2) endoplasmic reticulum (LRP2) plasma membrane (LRP2)
Anatomy Link Frequency
plasma 5
Anatomy 1
brain structures 1
nucleus accumbens 1
thyroid 1
LRP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
deep brain stimulation 347 100.00 Very High Very High Very High
depression 191 99.98 Very High Very High Very High
Nucleus accumbens 30 99.68 Very High Very High Very High
rheumatoid arthritis 350 99.52 Very High Very High Very High
Osteoarthritis 140 97.16 Very High Very High Very High
Inflammation 46 96.68 Very High Very High Very High
Neurosurgical lesion 12 93.60 High High
imagery 60 91.72 High High
antidepressant 12 85.00 Quite High
Anterior cingulate 6 82.72 Quite High
Disease Link Frequency Relevance Heat
Depression 199 99.98 Very High Very High Very High
Apoptosis 205 99.70 Very High Very High Very High
Disease 279 99.60 Very High Very High Very High
Anxiety Disorder 157 99.56 Very High Very High Very High
Rheumatoid Arthritis 350 99.52 Very High Very High Very High
Proteinuria 335 99.16 Very High Very High Very High
Acute Renal Failure 415 99.04 Very High Very High Very High
Burns 370 98.82 Very High Very High Very High
Autoimmune Disease 160 98.36 Very High Very High Very High
Systemic Lupus Erythematosus 180 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Burns septic ARF group plasma altered cytoskeleton distribution and megalin expression in tubular cells
Gene_expression (expression) of megalin in plasma associated with acute renal failure and burns
1) Confidence 0.75 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.89 Pain Relevance 0.09
By contrast, control healthy plasma did not alter the normal expression pattern of megalin (Figure 5C–E).


Gene_expression (expression) of megalin in plasma
2) Confidence 0.75 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.80 Pain Relevance 0.06
Burns septic ARF group plasma induced a significant decrease of megalin expression on tubular cells, suggesting that the impairment of tubular re-adsorption due either to apoptosis or to loss of megalin expression could contribute to proteinuria, resulting in the failure of tubular handling of filtered proteins.
Gene_expression (expression) of megalin in plasma associated with acute renal failure, burns, proteinuria and apoptosis
3) Confidence 0.75 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.30 Pain Relevance 0.07
They were expressed as an MBP fusion protein, recombinant LRP2 (rLRP2).
Gene_expression (expressed) of LRP2
4) Confidence 0.75 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 0.38 Pain Relevance 0.03
Burns septic ARF group plasma induced a significant decrease of megalin expression on tubular cells, suggesting that the impairment of tubular re-adsorption due either to apoptosis or to loss of megalin expression could contribute to proteinuria, resulting in the failure of tubular handling of filtered proteins.
Gene_expression (expression) of megalin in plasma associated with acute renal failure, burns, proteinuria and apoptosis
5) Confidence 0.75 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.43 Pain Relevance 0.07
The autoAbs to LRP2 are probably produced by the antigen-driven mechanism and the autoimmunity to LRP2 may spread to include CD69.
Gene_expression (produced) of LRP2 associated with autoimmune disease
6) Confidence 0.73 Published 2003 Journal Arthritis Res Ther Section Abstract Doc Link PMC165049 Disease Relevance 1.25 Pain Relevance 0.28
LRP2 is expressed in a variety of epithelia, such as renal proximal tubule, epididymis, and thyroid cells.
Gene_expression (expressed) of LRP2 in thyroid
7) Confidence 0.73 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 0.10 Pain Relevance 0
Plasmid construction for the expression of recombinant LRP2 and CD69 molecules
Gene_expression (expression) of recombinant LRP2
8) Confidence 0.63 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 1.04 Pain Relevance 0.16
They were expressed as an MBP fusion protein, recombinant LRP2 (rLRP2).
Gene_expression (expressed) of recombinant LRP2
9) Confidence 0.63 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 0.38 Pain Relevance 0.03
In the comparison according to disease category, the anti-LRP2 autoAbs were detected most frequently in RA, less frequently in SLE, SSc, and OA, and only rarely in Behçet's disease.
Gene_expression (autoAbs) of LRP2 associated with rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus, disease and osteoarthritis
10) Confidence 0.63 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 1.72 Pain Relevance 0.46
Moreover, plasma from septic burns patients induced an alteration of polarity in tubular cells, as well as reduced expression of the tight junction protein ZO-1 and of the endocytic receptor megalin.
Gene_expression (expression) of megalin in plasma associated with burns
11) Confidence 0.58 Published 2008 Journal Crit Care Section Abstract Doc Link PMC2447585 Disease Relevance 2.70 Pain Relevance 0.07
The produced and purified proteins of rLRP2-F2, -F3, and -F7, and rCD69 showed their expected molecular weights on staining with Ponceau S after SDS–PAGE separation and transfer to the membrane (Fig. 2, upper panel).
Gene_expression (produced) of LRP2 in upper
12) Confidence 0.58 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 0.32 Pain Relevance 0.03
Sixteen studies published between 1999 and 2009 were selected for review: nine for OCD [4-12], seven for TRD [10,13-18], and one for both disorders [19] (in Jimenez et al., 2007 [10], one patient with OCD and another with TRD underwent DBS).
Gene_expression (underwent) of DBS associated with deep brain stimulation, depression and anxiety disorder
13) Confidence 0.53 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2838907 Disease Relevance 1.05 Pain Relevance 0.47
Three patients with TRD were implanted with bilateral DBS electrodes in the nucleus accumbens.
Gene_expression (electrodes) of DBS in nucleus accumbens associated with nucleus accumbens, deep brain stimulation and depression
14) Confidence 0.53 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2838907 Disease Relevance 0.37 Pain Relevance 0.31
Anatomy of DBS sites
Gene_expression (sites) of DBS in Anatomy associated with deep brain stimulation
15) Confidence 0.53 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2838907 Disease Relevance 0.84 Pain Relevance 0.52
Expression of the recombinant LRP2 molecules
Gene_expression (Expression) of recombinant LRP2
16) Confidence 0.49 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 0.53 Pain Relevance 0.05
Another drawback of all of the above proposed methods is that, like the existing DBS procedure, it requires access to deep brain structures, whereas cortical stimulation would not.
Gene_expression (procedure) of DBS in brain structures
17) Confidence 0.32 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2920509 Disease Relevance 0.09 Pain Relevance 0
LRP2 is expressed in a variety of epithelia, such as renal proximal tubule, epididymis, and thyroid cells.
Gene_expression (expressed) of LRP2 in epididymis
18) Confidence 0.25 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 0.10 Pain Relevance 0
LRP2 is expressed in a variety of epithelia, such as renal proximal tubule, epididymis, and thyroid cells.
Gene_expression (expressed) of LRP2 in renal proximal tubule
19) Confidence 0.25 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 0.10 Pain Relevance 0
This would additionally provide visualization of the centre of the active contact of stimulation, the positioning of which is crucial to avoid DBS failure (Okun et al 2005).
Gene_expression (failure) of DBS associated with deep brain stimulation
20) Confidence 0.21 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646643 Disease Relevance 0.46 Pain Relevance 0.33

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