INT173912

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 6.22
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LRP2) endosome (LRP2) small molecule metabolic process (LRP2)
Golgi apparatus (LRP2) endoplasmic reticulum (LRP2) plasma membrane (LRP2)
Anatomy Link Frequency
plasma 2
urine 1
LRP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 35 92.56 High High
Inflammation 19 75.96 Quite High
Osteoarthritis 14 72.96 Quite High
Glutamate 1 59.92 Quite High
Pain 10 10.08 Low Low
intrathecal 13 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 82 99.72 Very High Very High Very High
Acute Renal Failure 166 99.26 Very High Very High Very High
Burns 148 99.04 Very High Very High Very High
Autoimmune Disease 16 96.40 Very High Very High Very High
Dystonia 25 94.64 High High
Rheumatoid Arthritis 35 92.56 High High
Disease 65 91.12 High High
Proteinuria 99 89.92 High High
Focal Dystonia 11 85.28 High High
Kidney Stones 41 80.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies in mice have demonstrated that inactivation of ClC-5 is associated with a severe trafficking defect in PT cells, with loss of megalin and cubilin at the brush border, subsequent loss of their ligands in the urine, and impaired lysosomal processing [22,23,27].
Negative_regulation (loss) of megalin in urine
1) Confidence 0.57 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2964617 Disease Relevance 0.77 Pain Relevance 0.03
We then tested whether burns septic ARF group plasma could induce early alterations in tubular cells not accountable to apoptosis such as down-regulation of megalin, an endocytic receptor involved in re-absorption of filtered proteins.
Negative_regulation (regulation) of megalin in plasma associated with acute renal failure, burns and apoptosis
2) Confidence 0.42 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.85 Pain Relevance 0.07
Burns septic ARF group plasma provoked a marked down-regulation of megalin (Figure 5D–E).
Negative_regulation (regulation) of megalin in plasma associated with acute renal failure and burns
3) Confidence 0.42 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.84 Pain Relevance 0.07
The anti-LRP2 autoAbs may play pathological roles by inhibiting the reabsorbing function of LRP2.



Negative_regulation (inhibiting) of LRP2
4) Confidence 0.40 Published 2003 Journal Arthritis Res Ther Section Abstract Doc Link PMC165049 Disease Relevance 1.14 Pain Relevance 0.25
A functional lesioning mechanism would be consistent with the comparable effect of pallidal DBS and surgical pallidotomy.
Negative_regulation (effect) of DBS
5) Confidence 0.02 Published 2009 Journal Ulster Med J Section Body Doc Link PMC2773587 Disease Relevance 0.61 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox