INT173914

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 6.49
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LRP2) endosome (LRP2) small molecule metabolic process (LRP2)
Golgi apparatus (LRP2) endoplasmic reticulum (LRP2) plasma membrane (LRP2)
Anatomy Link Frequency
plasma 4
LRP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 70 99.20 Very High Very High Very High
Inflammation 18 98.20 Very High Very High Very High
Osteoarthritis 28 97.72 Very High Very High Very High
cytokine 10 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Renal Failure 166 99.72 Very High Very High Very High
Disease 26 99.60 Very High Very High Very High
Burns 148 99.50 Very High Very High Very High
Rheumatoid Arthritis 70 99.20 Very High Very High Very High
Injury 30 98.48 Very High Very High Very High
Systemic Lupus Erythematosus 36 98.28 Very High Very High Very High
INFLAMMATION 28 98.20 Very High Very High Very High
Systemic Sclerosis 28 98.08 Very High Very High Very High
Osteoarthritis 28 97.72 Very High Very High Very High
Apoptosis 82 90.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Burns septic ARF group plasma altered cytoskeleton distribution and megalin expression in tubular cells
Regulation (altered) of Gene_expression (expression) of megalin in plasma associated with acute renal failure and burns
1) Confidence 0.60 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.91 Pain Relevance 0.09
By contrast, control healthy plasma did not alter the normal expression pattern of megalin (Figure 5C–E).


Neg (not) Regulation (alter) of Gene_expression (expression) of megalin in plasma
2) Confidence 0.60 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.81 Pain Relevance 0.06
In the comparison according to disease category, the anti-LRP2 autoAbs were detected most frequently in RA, less frequently in SLE, SSc, and OA, and only rarely in Behçet's disease.
Regulation (detected) of Gene_expression (autoAbs) of LRP2 associated with rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus, disease and osteoarthritis
3) Confidence 0.42 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 1.73 Pain Relevance 0.47
Plasmid construction for the expression of recombinant LRP2 and CD69 molecules
Regulation (molecules) of Gene_expression (expression) of recombinant LRP2
4) Confidence 0.37 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 1.04 Pain Relevance 0.16

General Comments

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