INT173916

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 7.96
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LRP2) endosome (LRP2) small molecule metabolic process (LRP2)
Golgi apparatus (LRP2) endoplasmic reticulum (LRP2) plasma membrane (LRP2)
Anatomy Link Frequency
plasma 3
LRP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
deep brain stimulation 93 100.00 Very High Very High Very High
depression 70 98.64 Very High Very High Very High
Osteoarthritis 14 82.36 Quite High
Inflammation 27 75.96 Quite High
Thalamus 9 75.48 Quite High
rheumatoid arthritis 35 72.88 Quite High
Thalamotomy 8 69.52 Quite High
cva 3 46.16 Quite Low
Multiple sclerosis 1 34.40 Quite Low
imagery 15 32.60 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 123 99.72 Very High Very High Very High
Acute Renal Failure 249 99.26 Very High Very High Very High
Burns 222 99.04 Very High Very High Very High
Anxiety Disorder 51 98.84 Very High Very High Very High
Depression 73 98.64 Very High Very High Very High
Parkinson's Disease 23 93.88 High High
Disease 124 91.52 High High
Tremor 15 90.24 High High
Systemic Sclerosis 14 86.08 High High
Obsessive-compulsive Disorder 9 83.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Burns septic ARF group plasma provoked a marked down-regulation of megalin (Figure 5D–E).
Regulation (regulation) of megalin in plasma associated with acute renal failure and burns
1) Confidence 0.44 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.84 Pain Relevance 0.07
By contrast, control healthy plasma did not alter the normal expression pattern of megalin (Figure 5C–E).


Neg (not) Regulation (alter) of megalin in plasma
2) Confidence 0.44 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.81 Pain Relevance 0.06
We then tested whether burns septic ARF group plasma could induce early alterations in tubular cells not accountable to apoptosis such as down-regulation of megalin, an endocytic receptor involved in re-absorption of filtered proteins.
Regulation (regulation) of megalin in plasma associated with acute renal failure, burns and apoptosis
3) Confidence 0.44 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.85 Pain Relevance 0.07
Plasmid construction for the expression of recombinant LRP2 and CD69 molecules
Regulation (molecules) of recombinant LRP2
4) Confidence 0.37 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 1.03 Pain Relevance 0.16
We included human studies that assessed the efficacy of DBS on psychiatric symptoms for OCD, TRD, or both.
Regulation (efficacy) of DBS associated with depression, deep brain stimulation and anxiety disorder
5) Confidence 0.21 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2838907 Disease Relevance 0.59 Pain Relevance 0.32
The relative safety and efficacy of STN vs GPi DBS, however, has been compared formerly in only small studies (Burchiel et al 1999).
Regulation (efficacy) of DBS associated with deep brain stimulation
6) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536542 Disease Relevance 0.83 Pain Relevance 0.46

General Comments

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