INT173928

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Context Info
Confidence 0.16
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 3.77
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Atp6v1e1) endosome (Atp6v1e1) transport (Atp6v1e1)
mitochondrion (Atp6v1e1) cytoplasm (Atp6v1e1)
Anatomy Link Frequency
spine 1
uterine 1
heart 1
body 1
Atp6v1e1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 273 95.80 Very High Very High Very High
substance P 22 90.00 High High
Inflammation 11 88.00 High High
Arthritis 12 84.24 Quite High
antagonist 14 82.84 Quite High
rheumatoid arthritis 59 82.64 Quite High
Central nervous system 43 68.40 Quite High
agonist 34 61.32 Quite High
Kinase C 21 55.60 Quite High
cytokine 38 53.96 Quite High
Disease Link Frequency Relevance Heat
Stroke 3 99.56 Very High Very High Very High
Obesity 145 99.22 Very High Very High Very High
Myocardial Infarction 39 99.16 Very High Very High Very High
Body Weight 71 99.12 Very High Very High Very High
Increased Venous Pressure Under Development 32 99.08 Very High Very High Very High
Coagulation Disorder 33 95.72 Very High Very High Very High
Disorder Of Lipid Metabolism 12 94.52 High High
Osteoporosis 21 93.32 High High
Lifespan 9 92.88 High High
Endometriosis (extended) 94 88.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
on body weight, WAT mass, and circulating lipid levels by E2 may be attributed, in part, to reductions in hepatic mRNA expression of PPAR?
Regulation (attributed) of E2 in body associated with body weight and obesity
1) Confidence 0.16 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.55 Pain Relevance 0
However, E2 is not solely responsible for protection from heart attack, progesterone also plays a role.
Neg (not) Regulation (responsible) of E2 in heart associated with myocardial infarction
2) Confidence 0.11 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.29 Pain Relevance 0.22
Changes in E2 typically occur in conjunction with changes in progesterone, and are to some degree dependent on progesterone priming.
Regulation (Changes) of E2
3) Confidence 0.11 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.25 Pain Relevance 0.09
played a so important role in the E2 and CpG regulation of PDCs in vitro, it is necessary to determine whether IFN-?
Regulation (regulation) of E2
4) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.16 Pain Relevance 0
This result had a same trend as the change of E2 level in vivo and the IFN-?
Regulation (change) of E2
5) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.13 Pain Relevance 0
and down regulate E2 ?
Regulation (regulate) of E2
6) Confidence 0.09 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.10 Pain Relevance 0.48
The present data show that the Tac4 gene is also a target of E2 and suggest that Tac4 expression is down-regulated by E2 surges, as those observed in mammals before ovulation or near labor.


Regulation (target) of E2
7) Confidence 0.09 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0.07 Pain Relevance 0.07
This study suggests that uterine tachykinins and tachykinin receptors are important targets of ovarian steroids and particularly of E2, acting at ER?.
Regulation (targets) of E2 in uterine
8) Confidence 0.09 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0.06 Pain Relevance 0.12
2×105 per well) for 72 h in CO2 incubator (the aim of designing one ratio was that the stimulatory capacity of this ratio is high and that it can fully reflect the influence of E2 and CpG on this capacity of PDCs).
Regulation (influence) of E2
9) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0
We did not find a significant association between the changes in E2 levels and IGF-1 after 2 years, which might be caused by the limited number of patients examined.
Regulation (changes) of E2
10) Confidence 0.04 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165058 Disease Relevance 0.87 Pain Relevance 0.27
Since the increase of E2 in serum was significantly correlated with improvement of BMD in the lumbar spine and total hip, we adjusted the correlation of sIL-6R and bone mass in the spine for the effect of changed E2 levels.
Regulation (effect) of E2 in spine
11) Confidence 0.03 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165058 Disease Relevance 0.28 Pain Relevance 0.17

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