INT173929

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Context Info
Confidence 0.26
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.02
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1rn) extracellular region (Il1rn) nucleus (Il1rn)
lipid metabolic process (Il1rn) cytoplasm (Il1rn)
Anatomy Link Frequency
fat 1
Il1rn (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 101 100.00 Very High Very High Very High
antagonist 12 100.00 Very High Very High Very High
Inflammation 74 99.98 Very High Very High Very High
rheumatoid arthritis 103 82.92 Quite High
agonist 6 73.68 Quite High
Arthritis 25 53.28 Quite High
tolerance 1 49.84 Quite Low
Inflammatory response 1 29.20 Quite Low
corticosteroid 9 5.00 Very Low Very Low Very Low
methotrexate 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 77 99.98 Very High Very High Very High
Obesity 82 98.44 Very High Very High Very High
Infection 28 86.60 High High
Systemic Lupus Erythematosus 2 84.24 Quite High
Rheumatoid Arthritis 103 82.92 Quite High
Autoimmune Disease 2 82.08 Quite High
Hypercalcemia 6 79.44 Quite High
Vomiting 3 78.16 Quite High
Endometriosis (extended) 18 66.88 Quite High
Sprains And Strains 2 63.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is supported by the fact that IL-1Ra and IL-10 response after LPS exposure is decreased in Ob/Ob mice [55], although we observed higher levels of IL-1Ra and IL-10 in HFD-fed obese mice in the present study.
Regulation (response) of IL-1Ra associated with obesity
1) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 0.88 Pain Relevance 0
The anti-inflammatory cytokines IL-1Ra and IL-10 were both markedly up-regulated in fat and serum in HFD-fed mice on day 5–7 after bacterial challenge.
Regulation (regulated) of cytokines IL-1Ra in fat associated with inflammation and cytokine
2) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 1.34 Pain Relevance 0.46
The mean value of IL-1Ra in Table 1 is higher than the value at baseline of patients who were followed up for the whole study period.
Regulation (value) of IL-1Ra
3) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165058 Disease Relevance 0.23 Pain Relevance 0.17
was also associated weakly with the change in sIL-6R and more strongly with the alterations in IL-1Ra and ESR and inversely to a smaller extent with the change in IGF-1.
Regulation (alterations) of IL-1Ra
4) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165058 Disease Relevance 0.20 Pain Relevance 0.14
Just as in the case of the baseline correlations, there were strong associations between the changes in serum levels of IL-6 and ESR (Fig. 1b) and of IL-6 and IL-1Ra.
Regulation (changes) of IL-1Ra
5) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165058 Disease Relevance 0.25 Pain Relevance 0.06
Directly targeting the IL-18R receptor, e.g. via antibody or specific antagonist, is also of potential interest, although shared utilisation with other IL-1 cytokines, e.g.
Regulation (targeting) of antagonist associated with antagonist and cytokine
6) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0 Pain Relevance 0.10

General Comments

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