INT173930

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Context Info
Confidence 0.17
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.46
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Atp6v1e1) endosome (Atp6v1e1) transport (Atp6v1e1)
mitochondrion (Atp6v1e1) cytoplasm (Atp6v1e1)
Atp6v1e1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 91 98.44 Very High Very High Very High
antagonist 5 85.48 High High
agonist 14 83.68 Quite High
anesthesia 2 72.28 Quite High
rheumatoid arthritis 29 67.52 Quite High
Inflammation 4 63.36 Quite High
Kinase C 7 52.48 Quite High
imagery 5 50.00 Quite Low
Central nervous system 15 45.96 Quite Low
Neurotransmitter 2 42.84 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 23 87.28 High High
Endometriosis (extended) 33 69.28 Quite High
Rheumatoid Arthritis 29 67.52 Quite High
INFLAMMATION 7 63.36 Quite High
Disease 7 60.48 Quite High
Coagulation Disorder 11 55.16 Quite High
Increased Venous Pressure Under Development 10 54.64 Quite High
Vomiting 6 40.84 Quite Low
Osteoporosis 9 24.00 Low Low
Apoptosis 6 5.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Higher levels of E2 in the presence of progesterone upregulate E2 ?
Positive_regulation (upregulate) of Gene_expression (presence) of E2
1) Confidence 0.17 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.11 Pain Relevance 0.49
In a second set of experiments, mice were treated with a) P4 (Sigma, 2 mg/mouse per day for 2 days) or its vehicle, and uteri collected 24 h after the last injection; b) a single injection of E2 (1 ?
Positive_regulation (injection) of Gene_expression (injection) of E2
2) Confidence 0.14 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.15
Because no data are available on the kinetics of placental transfer of EP, only data on placental transfer of E2 can be used for comparison.
Positive_regulation (transfer) of Gene_expression (transfer) of E2
3) Confidence 0.11 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.09 Pain Relevance 0
Increased serum levels of E2 were correlated with reduction of sIL-6R and TNF-?.
Positive_regulation (Increased) of Gene_expression (levels) of E2
4) Confidence 0.03 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165058 Disease Relevance 0.26 Pain Relevance 0.07

General Comments

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