INT173931

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2009
Negated 2
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.68
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1rn) extracellular region (Il1rn) nucleus (Il1rn)
lipid metabolic process (Il1rn) cytoplasm (Il1rn)
Anatomy Link Frequency
joint 4
immune system 2
Il1rn (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 94 93.48 High High
cytokine 133 92.20 High High
Arthritis 230 86.72 High High
antagonist 10 74.88 Quite High
rheumatoid arthritis 56 53.12 Quite High
Inflammatory response 8 38.88 Quite Low
chemokine 16 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 94 93.48 High High
Immunization 16 92.48 High High
Arthritis 255 86.72 High High
Experimental Arthritis 1 84.48 Quite High
Osteoporosis 7 72.88 Quite High
Infection 40 64.80 Quite High
Hypercalcemia 2 64.68 Quite High
Rheumatoid Arthritis 56 53.12 Quite High
Obesity 82 39.00 Quite Low
Sepsis 50 32.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The largest increase was seen in IL-1Ra gene (Il1rn) expression, which was up regulated 155-fold.
Regulation (up regula) of Gene_expression (n) express) of IL-1Ra
1) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 0.57 Pain Relevance 0.62
The largest increase was seen in IL-1Ra gene (Il1rn) expression, which was up regulated 155-fold.
Regulation (regulated) of Gene_expression (n) express) of Il1rn
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 0.57 Pain Relevance 0.62
Figure 6b shows that IL-1ra was detected in higher amounts in whole joint homogenates than in serum of both nonimmunized wild-type and E/P-selectin mutant mice, but we did not find differences in IL-1ra expression between nonimmunized wild-type and E/P-selectin joint homogenates, suggesting selectin deficiency does not significantly alter IL-1ra expression in the serum or joints.


Neg (not) Regulation (alter) of Gene_expression (expression) of IL-1ra in joint
3) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.66 Pain Relevance 0.24
Figure 6b shows that IL-1ra was detected in higher amounts in whole joint homogenates than in serum of both nonimmunized wild-type and E/P-selectin mutant mice, but we did not find differences in IL-1ra expression between nonimmunized wild-type and E/P-selectin joint homogenates, suggesting selectin deficiency does not significantly alter IL-1ra expression in the serum or joints.


Neg (not) Regulation (differences) of Gene_expression (expression) of IL-1ra in joint
4) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.61 Pain Relevance 0.22
One hypothesis to explain this finding is that vitamin D3, which affects the immune system [41] and was given to all the women studied, may have affected the production of IL-1Ra.
Spec (may) Regulation (affected) of Gene_expression (production) of IL-1Ra in immune system
5) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165058 Disease Relevance 0.28 Pain Relevance 0.13

General Comments

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