INT173940

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.97
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DMD) cytoskeleton (DMD) nucleus (DMD)
cytoplasm (DMD)
Anatomy Link Frequency
neck 2
hip 2
DMD (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 52 95.40 Very High Very High Very High
antagonist 16 93.52 High High
agonist 17 93.04 High High
corticosteroid 6 88.04 High High
Inflammation 10 40.32 Quite Low
Arthritis 6 36.56 Quite Low
cytokine 14 33.72 Quite Low
Bioavailability 13 19.84 Low Low
alcohol 27 5.00 Very Low Very Low Very Low
Potency 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 109 99.98 Very High Very High Very High
Osteoporosis 492 97.16 Very High Very High Very High
Rheumatoid Arthritis 55 95.40 Very High Very High Very High
Endometriosis (extended) 36 92.88 High High
Renal Insufficiency 1 89.40 High High
Osteoporotic Fractures 45 84.08 Quite High
Hypercalcemia 87 82.28 Quite High
Toxicity 4 81.88 Quite High
Hyperplasia 2 81.84 Quite High
Hypophosphatemia 1 80.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our study, isolated OVX for 10 weeks did not induce adequate reduction of the BMD.
Neg (not) Positive_regulation (induce) of Negative_regulation (reduction) of BMD
1) Confidence 0.59 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2876847 Disease Relevance 0.35 Pain Relevance 0.11
PTH stimulates both bone formation and resorption, leading to increased or decreased BMD, depending on the mode of administration.
Positive_regulation (increased) of Negative_regulation (decreased) of BMD
2) Confidence 0.17 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686344 Disease Relevance 0.65 Pain Relevance 0
Most studies suggest that measurements of broadband ultrasound attenuation (BUA) or speed of sound (SoS) at the heel are associated with a 1.5- to 2-fold increase in risk for each standard deviation decrease in BMD [15].
Positive_regulation (increase) of Negative_regulation (decrease) of BMD
3) Confidence 0.05 Published 2008 Journal Osteoporos Int Section Body Doc Link PMC2613968 Disease Relevance 0.28 Pain Relevance 0
For example, a widely cited meta-analysis [14] indicated that the risk of hip fracture increased 2.6-fold for each standard deviation decrease in BMD at the femoral neck.
Positive_regulation (increased) of Negative_regulation (decrease) of BMD in neck associated with frailty
4) Confidence 0.05 Published 2008 Journal Osteoporos Int Section Body Doc Link PMC2613968 Disease Relevance 0.31 Pain Relevance 0
In other words, the fracture risk increases 2.6-fold for each SD decrease in hip BMD.
Positive_regulation (increases) of Negative_regulation (decrease) of BMD in hip
5) Confidence 0.05 Published 2008 Journal Osteoporos Int Section Body Doc Link PMC2613968 Disease Relevance 0.34 Pain Relevance 0
Growth hormone (GH) contributes also in the regulation of bone metabolism: a deficiency of this hormone causes reduced BMD and replacement therapy has been shown to increase bone mass [3].
Positive_regulation (causes) of Negative_regulation (reduced) of BMD
6) Confidence 0.02 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165058 Disease Relevance 0.36 Pain Relevance 0.10
These drugs, as with other antiresorptive agents, improve bone strength and reduce fracture risk by decreasing bone turnover, resulting in stabilization or an increase in BMD, preservation of bone microarchitecture, reduction in trabecular perforation, and a decrease in cortical porosity.
Positive_regulation (increase) of Negative_regulation (reduction) of BMD
7) Confidence 0.02 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2773750 Disease Relevance 0.06 Pain Relevance 0.15
Administration of vehicle alone induced a further decline in BMD compared with untreated OVX controls.
Positive_regulation (induced) of Negative_regulation (decline) of BMD
8) Confidence 0.01 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.63 Pain Relevance 0

General Comments

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