INT173941

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Context Info
Confidence 0.04
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.48
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6R) extracellular region (IL6R) plasma membrane (IL6R)
enzyme binding (IL6R)
IL6R (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 100.00 Very High Very High Very High
cytokine 131 87.92 High High
Inflammation 30 50.00 Quite Low
rheumatoid arthritis 28 50.00 Quite Low
corticosteroid 3 26.16 Quite Low
cINOD 2 25.32 Quite Low
methotrexate 2 23.80 Low Low
Inflammatory mediators 16 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 32 96.84 Very High Very High Very High
Cancer 14 60.16 Quite High
INFLAMMATION 48 50.00 Quite Low
Rheumatoid Arthritis 28 50.00 Quite Low
Metaplasia 16 49.16 Quite Low
Lung Cancer 32 45.04 Quite Low
Vomiting 1 26.32 Quite Low
Disease 7 22.04 Low Low
Cleidocranial Dysplasia 8 5.00 Very Low Very Low Very Low
Leukemia 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Possible mechanisms are genetic and epigenetic changes [1,28] that lead to the inactivation of receptor genes such as silencing LIFR by DNA methylation [29] or enhanced expression of LIFR, OSMR, but reduced expression of IL-6R by acetylation of histone and transcription-controlling factors [22].
Negative_regulation (reduced) of Gene_expression (expression) of IL-6R
1) Confidence 0.04 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0 Pain Relevance 0.12
Interestingly, the same treatment reduced he expression of IL-6R in normal cells resulting in a response pattern as found in the corresponding carcinoma cells from the same patient (Fig. 6).


Negative_regulation (reduced) of Gene_expression (expression) of IL-6R associated with carcinoma
2) Confidence 0.04 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.48 Pain Relevance 0.03
Serum levels of sIL-6R, acting as an agonist to IL-6, were suppressed significantly in the HRT group after 12 and 24 months.
Negative_regulation (suppressed) of Gene_expression (levels) of sIL-6R associated with agonist
3) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165058 Disease Relevance 0 Pain Relevance 0.14

General Comments

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