INT173945

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Context Info
Confidence 0.01
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.32
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
Anatomy Link Frequency
osteoclast 2
Hrt1 (Mus musculus)
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 13 92.20 High High
rheumatoid arthritis 28 84.56 Quite High
Arthritis 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 28 84.56 Quite High
Rheumatic Diseases 3 76.72 Quite High
Osteoporosis 7 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Endometriosis (extended) 6 5.00 Very Low Very Low Very Low
Juvenile Chronic Polyarthritis 4 5.00 Very Low Very Low Very Low
Hypercalcemia 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HRT for 2 years resulted in an increase of the bone anabolic factor, insulin-like growth factor 1 (IGF-1) (P < 0.05) and a decrease of serum levels of soluble IL-6 receptor (sIL-6R) (P < 0.05), which is known to enhance the biological activity of IL-6, an osteoclast-stimulating and proinflammatory cytokine.
HRT Positive_regulation (resulted) of Positive_regulation (increase) of IGF-1 in osteoclast associated with cytokine
1) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Abstract Doc Link PMC165058 Disease Relevance 0.32 Pain Relevance 0.21

General Comments

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