INT173948

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.77
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gh, IGF1) extracellular space (Gh, IGF1) extracellular region (Gh, IGF1)
cytosol (Gh) mitochondrion (Gh) plasma membrane (Gh)
Anatomy Link Frequency
liver 2
Gh (Mus musculus)
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 28 92.00 High High
Inflammation 4 49.20 Quite Low
Arthritis 6 45.44 Quite Low
agonist 2 37.68 Quite Low
Somatostatin 10 31.12 Quite Low
cytokine 13 30.32 Quite Low
antagonist 4 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 28 92.00 High High
Hyperplasia 1 90.72 High High
Osteoporosis 9 76.56 Quite High
Stress 2 73.96 Quite High
Syndrome 4 69.84 Quite High
Appetite Loss 4 60.24 Quite High
Aging 66 50.00 Quite Low
INFLAMMATION 6 49.20 Quite Low
Disease 13 48.16 Quite Low
Juvenile Chronic Polyarthritis 4 46.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GH, in turn, stimulates the synthesis of insulin-like growth factor-I (IGF-I), which mediates many of GH’s effects and is a potent inhibitor of GH secretion (Merriam 2002).
GH Positive_regulation (stimulates) of Gene_expression (synthesis) of insulin-like growth factor-I
1) Confidence 0.36 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544358 Disease Relevance 0.20 Pain Relevance 0
GH is the primary inducer of IGF-1 synthesis by the liver and a central regulator of the concentration of circulating IGF-1 [3].
GH Positive_regulation (inducer) of Gene_expression (synthesis) of IGF-1 in liver
2) Confidence 0.05 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165058 Disease Relevance 0.36 Pain Relevance 0.10
GH, in turn, stimulates the synthesis of insulin-like growth factor-I (IGF-I), which mediates many of GH’s effects and is a potent inhibitor of GH secretion (Merriam 2002).
GH Positive_regulation (stimulates) of Gene_expression (synthesis) of IGF-I
3) Confidence 0.05 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544358 Disease Relevance 0.20 Pain Relevance 0

General Comments

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