INT173956

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.91
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CTLA4) plasma membrane (CTLA4)
Anatomy Link Frequency
T cells 2
CTLA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 99.72 Very High Very High Very High
tolerance 10 96.24 Very High Very High Very High
Inflammation 4 57.76 Quite High
rheumatoid arthritis 32 54.12 Quite High
withdrawal 1 6.16 Low Low
imagery 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
abatacept 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Sicca syndrome 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 13 97.12 Very High Very High Very High
Skin Cancer 112 95.72 Very High Very High Very High
Apoptosis 4 92.80 High High
Cancer 43 82.16 Quite High
Repression 1 75.40 Quite High
INFLAMMATION 4 57.76 Quite High
Rheumatoid Arthritis 32 54.12 Quite High
Sepsis 1 42.16 Quite Low
Myocardial Infarction 1 41.84 Quite Low
Disease 52 41.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The B7/CD28/CTLA-4 pathway
Negative_regulation (The) of Gene_expression (pathway) of CTLA-4
1) Confidence 0.37 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0
Thus anti-CTLA4 antibodies have been developed to abrogate these inhibitory interactions, favoring immune stimulation and in principle, breaking immune tolerance to melanoma.83
Negative_regulation (abrogate) of Gene_expression (antibodies) of anti-CTLA4 associated with tolerance and skin cancer
2) Confidence 0.20 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004577 Disease Relevance 0.35 Pain Relevance 0.10
The absence of CTLA4 surface expression on CD28- T cells may also play a role in their prolonged proliferative response and resistance to activation-induced cell death.
Negative_regulation (absence) of Gene_expression (expression) of CTLA4 in T cells associated with death
3) Confidence 0.05 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165060 Disease Relevance 0.56 Pain Relevance 0.10

General Comments

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