INT173974

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 16.81
Pain Relevance 5.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
B cells 6
T cell 6
macrophages 4
Dendritic cell 4
spleen 4
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 515 100.00 Very High Very High Very High
Inflammation 480 100.00 Very High Very High Very High
dexamethasone 4 99.62 Very High Very High Very High
anesthesia 18 98.76 Very High Very High Very High
methotrexate 32 98.16 Very High Very High Very High
adenocard 4 96.78 Very High Very High Very High
Thermal hyperalgesia 18 95.24 Very High Very High Very High
IPN 16 94.76 High High
chemokine 37 94.36 High High
Inflammatory response 78 93.76 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 573 100.00 Very High Very High Very High
Cytomegalovirus Infection 84 99.98 Very High Very High Very High
Obesity 52 99.72 Very High Very High Very High
Necrosis 33 99.54 Very High Very High Very High
Cancer 35 99.36 Very High Very High Very High
Apoptosis 143 98.32 Very High Very High Very High
Parasitemia 40 97.56 Very High Very High Very High
Mycobacterial Infection 116 97.44 Very High Very High Very High
Adhesions 16 97.36 Very High Very High Very High
Infection 677 96.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data demonstrate that M2 expression in primary murine B cells leads to enhanced secretion of several cytokines, most notably IL-10.
Positive_regulation (leads) of Localization (secretion) of IL-10 in B cells associated with cytokine
1) Confidence 0.68 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0 Pain Relevance 0.10
M2 protein expression leads to secretion of IL-10
Positive_regulation (leads) of Localization (secretion) of IL-10
2) Confidence 0.49 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0 Pain Relevance 0.12
These data point to a potential role of M2 protein-mediated IL-10 secretion in the quiescence of the virus-specific T cell response in vivo which may facilitate both the efficient establishment of latency as well as reactivation from latency.


Positive_regulation (role) of Localization (secretion) of IL-10 in T cell
3) Confidence 0.46 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.18 Pain Relevance 0
Our work demonstrates that the M2 protein, a unique viral protein, manipulates B cell signaling to induce cellular IL-10 secretion and make cells more responsive to IL-10 signaling, leading to proliferation and enhanced survival of M2-expressing primary B cells in culture.
Positive_regulation (induce) of Localization (secretion) of IL-10 in B cell
4) Confidence 0.46 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.22 Pain Relevance 0
It has been shown that ex vivo stimulation of MHV68 latently infected splenocytes with MHV68-infected antigen presenting cells resulted in IL-10 secretion peaking at the onset of splenic latency, and B cells were shown to be responsible for a significant portion of the IL-10 secreted [47].
Positive_regulation (resulted) of Localization (secretion) of IL-10 in B cells
5) Confidence 0.46 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.11 Pain Relevance 0.07
These data point to a potential role of M2 protein-mediated IL-10 secretion in the quiescence of the virus-specific T cell response in vivo which may facilitate both the efficient establishment of latency as well as reactivation from latency.


Positive_regulation (mediated) of Localization (secretion) of IL-10 in T cell
6) Confidence 0.46 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.18 Pain Relevance 0
and an augmentation of the increase of IL-10 by 7-NINA and L-NAME may contribute to the mechanism by which pretreatment with 7-NINA and L-NAME reduces CFA-induced thermal hyperalgesia.
Positive_regulation (augmentation) of Localization (increase) of IL-10 associated with thermal hyperalgesia
7) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 1.22 Pain Relevance 0.39
This was accompanied by an increase in the systemic release of IL-10 with a parallel increase in the number of MAC-3+ and CD4+ T spleen cells expressing IL-10.
Positive_regulation (increase) of Localization (release) of IL-10 in spleen
8) Confidence 0.32 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2953483 Disease Relevance 1.59 Pain Relevance 0.20
This was accompanied by an increase in the systemic release of IL-10 with a parallel increase in the number of MAC-3+ and CD4+ T spleen cells expressing IL-10.
Positive_regulation (increase) of Localization (release) of IL-10 in spleen
9) Confidence 0.32 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2953483 Disease Relevance 1.55 Pain Relevance 0.17
In animal models using adult mice, it has been shown that both Gram-negative bacteria and mycobacteria induced the recruitment of neutrophils, which secrete abundant amounts of IL-10 (Zhang et al., 2009).
Positive_regulation (induced) of Localization (secrete) of IL-10 in neutrophils
10) Confidence 0.29 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.84 Pain Relevance 0.15
The MC3R-induced secretion of IL-10 underscores the potential importance of MC3R as an anti-inflammatory modulator due to the ability of IL-10 to inhibit inflammatory cytokines, including IL-6, TNF-?
Positive_regulation (induced) of Localization (secretion) of IL-10 associated with inflammation and cytokine
11) Confidence 0.23 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.69 Pain Relevance 0.46
of dexamethasone does not cause an increase in IL-10 secretion from CD4+ cells.
Positive_regulation (increase) of Localization (secretion) of IL-10 associated with dexamethasone
12) Confidence 0.22 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 0.66 Pain Relevance 0.25
Dendritic cell differentiation in a cholestatic hepatic environment may lead to Th2 polarization and secretion of IL4 and IL10, rather than IFN?
Spec (may) Positive_regulation (lead) of Localization (secretion) of IL10 in Dendritic cell
13) Confidence 0.21 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 0.88 Pain Relevance 0.18
Dendritic cell differentiation in a cholestatic hepatic environment may lead to Th2 polarization and secretion of IL4 and IL10, rather than IFN?
Positive_regulation (than) of Localization (secretion) of IL10 in Dendritic cell
14) Confidence 0.21 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 0.88 Pain Relevance 0.18
Surgery also contributes to the deviation of the immune response toward a Th2 and patients undergoing surgery and anesthesia have shown to present with down-regulated IL-2 secretion and up-regulated IL-10 and IL-4 secretion during the postoperative period.[34] However, in our study these confounding factors did not play much role as all patients underwent surgical procedures of almost similar duration, same type of anesthesia and single team of surgeons.
Positive_regulation (up) of Localization (secretion) of IL-10 associated with anesthesia and cytokine
15) Confidence 0.19 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0.17 Pain Relevance 0.32
Thus, by increasing the concentrations of IL-10 and TGF-?
Positive_regulation (increasing) of Localization (concentrations) of IL-10
16) Confidence 0.18 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.31 Pain Relevance 0.20
Transduction by TREM2 enabled BM-MC to release a substantial amount of IL-10 after stimulation as determined by ELISA (Figure 3D).
Positive_regulation (enabled) of Localization (release) of IL-10
17) Confidence 0.18 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.44 Pain Relevance 0.30
Increases in IL-12p70 were balanced by similar increases in IL-10 secretion (Fig. 3b).
Positive_regulation (increases) of Localization (secretion) of IL-10
18) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.11 Pain Relevance 0.29
Intriguingly, vaults containing another protein, GL, but not empty vaults, also significantly induced the maturation of BMDC by causing secretion of IL-12p70, IL-10 and CXCL10 but not IL-4 (data not shown) suggesting that vaults containing proteins favor induction of Th1 immune responses.
Positive_regulation (induced) of Localization (secretion) of IL-10
19) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.30 Pain Relevance 0.39
In the early phase of infection cytomegalovirus causes release of IL-10 [28].
Positive_regulation (causes) of Localization (release) of IL-10 associated with cytomegalovirus infection
20) Confidence 0.11 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1878503 Disease Relevance 1.50 Pain Relevance 0.04

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