INT17399

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Context Info
Confidence 0.69
First Reported 1980
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 7.05
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
Anatomy Link Frequency
plasma 10
brain 2
vessels 2
sympathetic nervous system 2
kidney 2
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 6 100.00 Very High Very High Very High
noradrenaline 2 100.00 Very High Very High Very High
narcan 8 98.30 Very High Very High Very High
beta blocker 7 90.64 High High
antagonist 8 86.56 High High
opiate 2 85.40 High High
Clonidine 4 84.96 Quite High
Serotonin 2 75.00 Quite High
Opioid 2 75.00 Quite High
headache 13 66.00 Quite High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 7 99.38 Very High Very High Very High
Pressure And Volume Under Development 43 98.68 Very High Very High Very High
Disorders Of Creatine Metabolism 1 98.44 Very High Very High Very High
Hypertension 150 98.24 Very High Very High Very High
Obesity 70 97.52 Very High Very High Very High
Altitude Sickness 65 95.68 Very High Very High Very High
Hepatotoxicity 1 95.32 Very High Very High Very High
Left Ventricular Hypertrophy 3 94.00 High High
Hypoxia 66 93.40 High High
Renal Insufficiency 1 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased prostaglandin production follows renin activation; simultaneously, the arterial vessels show diminished angiotensin sensitivity.
Positive_regulation (follows) of Positive_regulation (activation) of renin in vessels
1) Confidence 0.69 Published 1995 Journal Anaesthesist Section Abstract Doc Link 7653790 Disease Relevance 0.73 Pain Relevance 0
Naloxone infusion produced the expected increases in LH and cortisol, but also significantly enhanced the elevations in prolactin, adrenaline, noradrenaline, plasma renin activity and aldosterone (P less than 0.05).
Positive_regulation (enhanced) of Positive_regulation (elevations) of renin in plasma associated with noradrenaline and narcan
2) Confidence 0.53 Published 1984 Journal Clin. Sci. Section Abstract Doc Link 6383692 Disease Relevance 0 Pain Relevance 0.48
The present results, however, do not allow us to conclude that the renal 5-HT receptors play a physiological role in the control of renin release.
Positive_regulation (role) of Positive_regulation (control) of renin
3) Confidence 0.48 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1905236 Disease Relevance 0 Pain Relevance 0.15
Aliskiren is well tolerated by all age groups, including the very elderly, and there are no indications to change the recommended dose of aliskiren in patients with hepatic and renal insufficiency because the peak concentration, area under the curve (AUC), and half-life were only slightly greater in patients with hepatic dysfunction.52 Aliskiren exposure was also increased slightly in patients with renal function impairment, but these changes did not correlate with creatinine clearance.62 All agents that inhibit the RAAS activate the negative feedback loop that leads to a compensatory increase in plasma renin concentration.
Positive_regulation (leads) of Positive_regulation (increase) of renin in plasma associated with disorders of creatine metabolism, renal insufficiency and hepatotoxicity
4) Confidence 0.41 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922316 Disease Relevance 0.90 Pain Relevance 0.12
Unlike the angiotensin-converting enzyme inhibitors and the angiotensin II receptor blockers (ARBs), which reactively stimulate an increase in plasma renin activity, aliskiren suppresses the effects of renin and leads to a reduction in plasma renin activity.
Positive_regulation (stimulate) of Positive_regulation (increase) of renin in plasma
5) Confidence 0.34 Published 2009 Journal Pharmacotherapy Section Abstract Doc Link 19170589 Disease Relevance 0.33 Pain Relevance 0
Furthermore, the negative effect of thiazides, of increasing free radical levels through induction of the renin–angiotensin system, could be counterbalanced by zofenopril's antioxidant effect in the combination.


Positive_regulation (increasing) of Positive_regulation (induction) of renin
6) Confidence 0.24 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994025 Disease Relevance 0.40 Pain Relevance 0.07
In addition, HCTZ may increase oxidant activity via an activation of the renin–angiotensin system, and zofenopril has a direct antioxidant effect in humans (Napoli et al 2004).
Spec (may) Positive_regulation (increase) of Positive_regulation (activation) of renin
7) Confidence 0.24 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994025 Disease Relevance 0.25 Pain Relevance 0
We nevertheless believe that this system was effectively blocked, as indicated by the expected changes in plasma renin activity (increased after enalaprilat and candesartan) and in angiotensin II immunoreactivity (abolished after enalaprilat and increased after candesartan), and by the 15–17% reduction in mean aortic pressure.
Positive_regulation (increased) of Positive_regulation (increased) of plasma renin in plasma
8) Confidence 0.13 Published 2004 Journal Crit Care Section Body Doc Link PMC522832 Disease Relevance 0.68 Pain Relevance 0.04
It is worth mentioning that obesity is associated with sodium retention and increased extracellular volume inducing hypervolemia and increased cardiac output, leading to the activation of the renin–angiotensin and sympathetic nervous system; all of these factors contributing ultimately to the development of hypertension and eccentric-concentric left ventricular hypertrophy: changes that may induce congestive heart failure, arrhythmia, and sudden death (Figure 2) (Zhang and Reisin 2000).
Positive_regulation (leading) of Positive_regulation (activation) of renin in sympathetic nervous system associated with heart rate under development, left ventricular hypertrophy, pressure volume 2 under development, hypertension, obesity, arrhythmia under development and sudden death
9) Confidence 0.10 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993994 Disease Relevance 1.26 Pain Relevance 0.21
RAO induced an increase in arterial plasma renin activity and this increase was accompanied by an increase in RVR in the contralateral kidney and rise in SBP.
Positive_regulation (induced) of Positive_regulation (increase) of renin in kidney
10) Confidence 0.08 Published 1980 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7009942 Disease Relevance 0 Pain Relevance 0
It was initially thought that ACE inhibitors were likely to be most useful as antihypertensive agents in conditions in which circulating renin and angiotensin II were elevated.
Positive_regulation (elevated) of Positive_regulation (elevated) of renin
11) Confidence 0.07 Published 1990 Journal Drugs Section Abstract Doc Link 2226219 Disease Relevance 0.24 Pain Relevance 0.07
While the mechanism of action for the antihypertensive effect of thiazides is not fully elucidated, it is known that they cause indirect activation of the renin-angiotensin system (RAS), providing a rationale for combining HCTZ with ACE inhibitors and ARBs.
Positive_regulation (cause) of Positive_regulation (activation) of renin
12) Confidence 0.03 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663442 Disease Relevance 0.23 Pain Relevance 0.05
Elevated levels of antidiuretic hormone, activation of the renin-angiotensin-aldosterone system and an enhanced sympathetic drive contribute to fluid retention by the kidneys.[25] Moderate-to-severe AMS is associated with white matter edema in the brain.
Positive_regulation (levels) of Positive_regulation (activation) of renin-angiotensin-aldosterone in brain associated with pressure and volume under development and altitude sickness
13) Confidence 0.01 Published 2010 Journal Indian Journal of Occupational and Environmental Medicine Section Body Doc Link PMC2923424 Disease Relevance 1.62 Pain Relevance 0.08
The results showed that the patient group had lower levels of beta-endorphin and leucine enkephalin (P < 0.001), higher levels of arginine vasopressin, plasma renin activity and angiotensin II (P < 0.01, P < 0.05 and P < 0.05, respectively), and normal level of neurotensin, as compared with those in normal group.
Positive_regulation (had) of Positive_regulation (levels) of plasma renin in plasma associated with enkephalin
14) Confidence 0.01 Published 1995 Journal Int. J. Cardiol. Section Abstract Doc Link 8586472 Disease Relevance 0.42 Pain Relevance 0.64

General Comments

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