INT17401

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 475
Total Number 478
Disease Relevance 232.18
Pain Relevance 62.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
Anatomy Link Frequency
cartilage 31
liver 27
chondrocytes 21
PGE2 9
plasma 8
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1121 100.00 Very High Very High Very High
Fibrositis 400 100.00 Very High Very High Very High
COX2 87 100.00 Very High Very High Very High
chemokine 81 100.00 Very High Very High Very High
Osteoarthritis 1742 99.92 Very High Very High Very High
Inflammation 3171 99.86 Very High Very High Very High
Arthritis 770 99.84 Very High Very High Very High
headache 221 99.84 Very High Very High Very High
Clonidine 74 99.84 Very High Very High Very High
Neuritis 15 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 3190 100.00 Very High Very High Very High
Prostate Cancer 719 100.00 Very High Very High Very High
Benign Prostatic Hypertrophy 384 100.00 Very High Very High Very High
Osteoarthritis 1756 99.92 Very High Very High Very High
Aging 590 99.92 Very High Very High Very High
Dementia 36 99.92 Very High Very High Very High
INFLAMMATION 3302 99.86 Very High Very High Very High
Osteoporosis 581 99.84 Very High Very High Very High
Headache 197 99.84 Very High Very High Very High
Pancreatic Cancer 95 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Injury of a tissue or organ rapidly induced extensive blood vessel formation and such new blood vessels transiently expressed IGF-I immunoreactivity.
Gene_expression (expressed) of IGF-I in blood vessels associated with injury
1) Confidence 0.78 Published 1989 Journal Exp. Mol. Pathol. Section Abstract Doc Link 2465916 Disease Relevance 0.36 Pain Relevance 0
The IGF-1 generation test assesses the capacity of the liver to produce IGF-1 after administration of exogenous rhGH.
Gene_expression (produce) of IGF-1 in liver
2) Confidence 0.78 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.55 Pain Relevance 0.04
In these conditions the GH secretion is normal but peripheral effects is compromised with low or very low levels of serum IGF-1, due to a type of GH resistance or more often to alteration of IGF-1 production from the liver.2,10
Gene_expression (production) of IGF-1 in liver
3) Confidence 0.78 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.81 Pain Relevance 0
Secondary or acquired GHI is characterized by GH–IGF-1 axis dysfunction due to malnutrition, liver diseases, catabolic illness, or neutralizing antibodies to growth hormones, affecting IGF-1 production and action.
Gene_expression (production) of IGF-1 in liver associated with liver disease, laron syndrome and nutritional deficiencies
4) Confidence 0.78 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.80 Pain Relevance 0
Under basal condition, OA Ob expressed similar IGF-1 mRNA to normal Ob; however, PGE2 stimulated IGF-1 mRNA expression more in OA than normal Ob.
Gene_expression (expression) of IGF-1 mRNA in PGE2 associated with osteoarthritis
5) Confidence 0.77 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 0.92 Pain Relevance 0.59
The PGE2-dependent stimulation of IGF-1 synthesis was due in part to the cAMP/protein kinase A pathway since both the direct inhibition of this pathway with H-89 and the inhibition of EP2 or EP4 receptors, linked to cAMP production, reduced IGF-1 synthesis.
Gene_expression (synthesis) of IGF-1 in PGE2
6) Confidence 0.77 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.18 Pain Relevance 0.66
The production of the most abundant IGF-1 binding proteins (IGFBPs) in bone tissue, IGFBP-3, -4, and -5, was lower in OA compared to normal Ob independently of the OA group.
Gene_expression (production) of IGF-1 in bone tissue associated with osteoarthritis
7) Confidence 0.77 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.19 Pain Relevance 0.68
Conversely, only the high OA group showed a significant inhibition of IGF-1 production when PGE2 synthesis was reduced with Naproxen, a non-steroidal antiinflammatory drug (NSAID) that inhibits cyclooxygenases (COX).
Gene_expression (production) of IGF-1 in PGE2 associated with inflammation, cinod and osteoarthritis
8) Confidence 0.77 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.54 Pain Relevance 0.68
The PGE2-dependent stimulation of IGF-1 synthesis was due in part to the cAMP/protein kinase A pathway since both the direct inhibition of this pathway with H-89 and the inhibition of EP2 or EP4 receptors, linked to cAMP production, reduced IGF-1 synthesis.
Gene_expression (synthesis) of IGF-1 in PGE2
9) Confidence 0.77 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.52 Pain Relevance 0.69
As parathyroid hormone (PTH) and PGE2 are known stimulators of IGF-1 production in Ob, we next evaluated their effect in OA Ob.
Gene_expression (production) of IGF-1 in parathyroid associated with osteoarthritis
10) Confidence 0.77 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.46 Pain Relevance 0.61
Both subgroups increased their IGF-1 production similarly in response to PGE2, while the high OA subgroup showed a blunted response to PTH compared to the low OA group.
Gene_expression (production) of IGF-1 in PGE2 associated with osteoarthritis
11) Confidence 0.77 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.45 Pain Relevance 0.62
Real time quantitative RT-PCR with internal fluorescent hybridization probes was performed as previously described [22] and the IGF-1 gene expression was quantified using a commercially available Gene Expression Assay kit (Applied Biosystems, CA).
Gene_expression (expression) of IGF-1 gene in internal
12) Confidence 0.77 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0 Pain Relevance 0
Indeed, there appears to be excellent evidence that growth restriction with chronic inflammation, including arthritis, is the result of suppression of IGF-1 production and activity, independent of GH, and in response to IL-6 [41,42].
Gene_expression (production) of IGF-1 associated with inflammation and arthritis
13) Confidence 0.77 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.51 Pain Relevance 0.21
Concomitant with a suppression of local, autocrine production of IGF-1 during inflammation is an uncoupling of the signal transduction pathways for exogenous Growth Hormone (GH) and IGF-1 [34-36].
Gene_expression (production) of IGF-1 associated with inflammation
14) Confidence 0.77 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.61 Pain Relevance 0.30
IGF-1 production from human cartilage explants was also enhanced 67% by vincaria alone (10 ?
Gene_expression (production) of IGF-1 in cartilage
15) Confidence 0.77 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.07 Pain Relevance 0.07
While RNI 249 stimulates basal IGF-1 gene expression and production in human cartilage, it was necessary to determine if this action was retained in the presence of IL-1?.
Gene_expression (expression) of IGF-1 gene in cartilage
16) Confidence 0.77 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.09 Pain Relevance 0.09
This is conceptually similar to the approach used in the present study – enhanced autocrine production of IGF-1 and suppression of inhibitory cytokine tone.
Gene_expression (production) of IGF-1 associated with cytokine
17) Confidence 0.77 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.10 Pain Relevance 0.09
on IGF-1 production
Gene_expression (production) of IGF-1
18) Confidence 0.77 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.09 Pain Relevance 0.09
It has been well appreciated that inflammation and infection silences the expression of repair pathways like IGF-1 [32,33].
Gene_expression (expression) of IGF-1 associated with inflammation and infection
19) Confidence 0.77 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.68 Pain Relevance 0.34
(5 ng/ml) exposed explants displayed a complete suppression of IGF-1 production (Figure 3).
Gene_expression (production) of IGF-1
20) Confidence 0.77 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.09 Pain Relevance 0.09

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