INT174028

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Context Info
Confidence 0.19
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.18
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ADAMTS5) extracellular region (ADAMTS5) proteinaceous extracellular matrix (ADAMTS5)
Anatomy Link Frequency
tendon cells 1
tendons 1
cleavage 1
ADAMTS5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 142 99.84 Very High Very High Very High
metalloproteinase 45 99.52 Very High Very High Very High
Inflammatory mediators 5 98.72 Very High Very High Very High
Osteoarthritis 584 97.04 Very High Very High Very High
Inflammation 126 93.60 High High
cytokine 109 90.60 High High
cINOD 36 83.84 Quite High
Mechanotransduction 5 82.72 Quite High
bradykinin 1 72.88 Quite High
Arthritis 14 60.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 134 98.72 Very High Very High Very High
Cancer 22 98.40 Very High Very High Very High
Necrosis 18 98.12 Very High Very High Very High
Osteoarthritis 582 97.04 Very High Very High Very High
Disease 119 85.84 High High
Disease Progression 24 72.16 Quite High
Steatorrhea 1 65.20 Quite High
Eructation 1 63.04 Quite High
Arthritis 27 60.56 Quite High
Depression 1 56.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
had contrasting effects on these two mRNA, inducing a small (2- to 3-fold) transient stimulation of ADAMTS-1 mRNA expression at 24 h (Fig. 6B) and a persistent decrease of ADAMTS-5 mRNA (Fig. 6D).


Negative_regulation (decrease) of ADAMTS-5
1) Confidence 0.19 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.09
In further contrast with ADAMTS-4, levels of both ADAMTS-1 and ADAMTS-5 mRNA were lower in cells in collagen gel cultures compared with monolayers (Table 1).
Negative_regulation (lower) of ADAMTS-5
2) Confidence 0.14 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.06
We found that placing tendon cells in a three-dimensional collagen gel (a version of the fibroblast-populated collagen lattice: Ehrlich and Rittenberg, 2000; Grinnell, 2003) increased the expression of ADAMTS-4 mRNA relative to the monolayer and decreased that of ADAMTS-1 and ADAMTS-5 (Table 1).
Negative_regulation (decreased) of ADAMTS-5 in tendon cells
3) Confidence 0.12 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.12
We noted previously (Jones et al., 2006) that ADAMTS-1 mRNA expression showed little variation between tendon tissue sample groups while ADAMTS-5 mRNA decreased in painful tendons, thus contrasting with the pattern of ADAMTS-4 mRNA expression.
Negative_regulation (decreased) of ADAMTS-5 in tendons associated with pain
4) Confidence 0.12 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.14
None of EGF, FGF and PDGF had a significant effect on ADAMTS-1 mRNA expression (Fig. 6A), but each induced significant decreases in ADAMTS-5 mRNA levels (P < 0.01, except for PDGF P < 0.05), which were maintained over 48 h (Fig. 6C).
Negative_regulation (decreases) of ADAMTS-5
5) Confidence 0.12 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.13
A selective inhibitor of aggrecanase and MMP-13 was recently reported [88].


Negative_regulation (inhibitor) of aggrecanase
6) Confidence 0.08 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.66 Pain Relevance 0.21
Although no true selective inhibitor of aggrecanase has been reported, efforts to discover tumour necrosis factor-?
Neg (no) Negative_regulation (inhibitor) of aggrecanase associated with necrosis and cancer
7) Confidence 0.08 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.64 Pain Relevance 0.19
Synthetic inhibitors originally targeted for MMPs often inhibit aggrecanase.
Negative_regulation (inhibit) of aggrecanase
8) Confidence 0.07 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.64 Pain Relevance 0.19
-induced proteoglycan catabolism by inhibition of the cleavage enzyme aggrecanase [28], and of the production of inflammatory mediators (prostaglandin E2, nitric oxide) [52-55] and metalloproteinases [52-54], and the downregulation of glucuronosyltransferase [52].
Negative_regulation (inhibition) of aggrecanase in cleavage associated with inflammatory mediators and metalloproteinase
9) Confidence 0.04 Published 2003 Journal BMC Complement Altern Med Section Body Doc Link PMC165439 Disease Relevance 0.24 Pain Relevance 0.27
Omega-3 EFA, found in fish oil, can directly reduce the degenerative enzymes, aggrecanase and matrix metalloproteinase, as well as IL-1, TNF-?
Negative_regulation (reduce) of aggrecanase associated with metalloproteinase
10) Confidence 0.01 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 1.00 Pain Relevance 0.59

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