INT174029

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Context Info
Confidence 0.01
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.50
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BSG) small molecule metabolic process (BSG) plasma membrane (BSG)
Anatomy Link Frequency
joints 1
chondrocytes 1
BSG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 18 97.72 Very High Very High Very High
imagery 24 90.24 High High
metalloproteinase 52 84.08 Quite High
spinal inflammation 54 83.60 Quite High
cINOD 23 75.76 Quite High
Osteoarthritis 12 65.08 Quite High
Facet joint 1 54.24 Quite High
Adalimumab 19 38.12 Quite Low
Etanercept 5 37.32 Quite Low
Infliximab 6 36.68 Quite Low
Disease Link Frequency Relevance Heat
Breast Cancer 59 99.26 Very High Very High Very High
Disease 33 98.20 Very High Very High Very High
INFLAMMATION 24 97.72 Very High Very High Very High
Intervertebral Disk Degeneration 12 92.56 High High
Aneurism 11 91.36 High High
Aortic Aneurysms 3 88.48 High High
Low Back Pain 58 83.60 Quite High
Osteoporosis 9 72.64 Quite High
Cancer 27 72.20 Quite High
Osteoarthritis 11 65.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Extracellular exogenous proteins are endocytosed and undergo degradation in the acidic endosomal compartment.
Protein_catabolism (degradation) of Extracellular
1) Confidence 0.01 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0 Pain Relevance 0
A large amount of research has implicated increased MMP activity as an important factor in increased extracellular degradation (Lassila 1993; Gronholdt et al 1998; Herman et al 2001).
Protein_catabolism (degradation) of extracellular
2) Confidence 0.01 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993941 Disease Relevance 0.24 Pain Relevance 0.14
They are bioavailable to cartilage chondrocytes, may stimulate the biosynthesis and inhibit the breakdown of their extracellular matrix proteoglycans.


Protein_catabolism (breakdown) of extracellular in chondrocytes
3) Confidence 0.01 Published 2003 Journal BMC Complement Altern Med Section Abstract Doc Link PMC165439 Disease Relevance 0.52 Pain Relevance 0.23
MMP-3 degrades extracellular matrix proteins and is involved in disruptive events in the cartilage and bone of inflamed joints [15].
Protein_catabolism (degrades) of extracellular in joints
4) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592815 Disease Relevance 1.10 Pain Relevance 0.44
The 3 breast cancer cell lines all produced significant degradation of the 3 collagenous extracellular matrices (ECMs) whilst the normal breast cell line was without effect.
Protein_catabolism (degradation) of extracellular associated with breast cancer
5) Confidence 0.01 Published 2005 Journal Cancer Cell Int Section Abstract Doc Link PMC548674 Disease Relevance 0.64 Pain Relevance 0.14

General Comments

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