INT174054

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 25
Total Number 31
Disease Relevance 21.30
Pain Relevance 3.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep) extracellular space (Lep) extracellular region (Lep)
intracellular (Lep) lipid metabolic process (Lep)
Anatomy Link Frequency
chondrocytes 6
plasma 6
cartilage 4
grey matter 2
muscle 2
Lep (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 31 100.00 Very High Very High Very High
Osteoarthritis 870 99.98 Very High Very High Very High
long-term potentiation 51 99.96 Very High Very High Very High
Inflammatory mediators 18 99.24 Very High Very High Very High
cytokine 235 98.20 Very High Very High Very High
depression 37 97.08 Very High Very High Very High
nMDA receptor 97 96.80 Very High Very High Very High
addiction 7 95.52 Very High Very High Very High
Nicotine 1 95.04 Very High Very High Very High
Central nervous system 22 93.68 High High
Disease Link Frequency Relevance Heat
Disseminated Intravascular Coagulation 24 100.00 Very High Very High Very High
Osteoarthritis 720 99.98 Very High Very High Very High
Hypoxia 30 99.98 Very High Very High Very High
Hypercapnia 40 99.88 Very High Very High Very High
Obesity 1687 99.84 Very High Very High Very High
Diabetes Mellitus 59 99.32 Very High Very High Very High
INFLAMMATION 326 99.24 Very High Very High Very High
Apoptosis 51 99.00 Very High Very High Very High
Albuminuria 12 98.78 Very High Very High Very High
Targeted Disruption 57 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Osteoarthritis increases the expression of leptin and leptin receptors in chondrocytes [49], suggesting that physiologic levels of leptin may mediate the production of inflammatory mediators in osteoarthritic but not normal tissue.
Positive_regulation (increases) of Gene_expression (expression) of leptin in chondrocytes associated with inflammatory mediators and osteoarthritis
1) Confidence 0.69 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.71 Pain Relevance 0.28
The need for costimulation with mitogens to get the effect of leptin in lymphocytes may be partly explained by this effect of activation, increasing leptin receptor expression in T lymphocytes.
Positive_regulation (increasing) of Gene_expression (expression) of leptin in T lymphocytes
2) Confidence 0.61 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0 Pain Relevance 0.11
It is unknown whether mechanical loading can induce the expression of leptin within the joint, as has been shown for IL-6 [29,55]; such an effect, if any, could explain in part the leptin dependence of the associations between measures of adiposity and hip OA we report in the current study.
Positive_regulation (induce) of Gene_expression (expression) of leptin in hip associated with addiction and osteoarthritis
3) Confidence 0.60 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911879 Disease Relevance 0.75 Pain Relevance 0.19
We observed increased serum leptin levels in preeclamptic CBA/J x DBA/2 mice.
Positive_regulation (increased) of Gene_expression (levels) of leptin
4) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965104 Disease Relevance 0.66 Pain Relevance 0
On the other hand, increased leptin levels are associated with increased concentrations of other proinflammatory cytokines such as IL-1, IL-6, IL-8, TNF?
Positive_regulation (increased) of Gene_expression (levels) of leptin associated with cytokine
5) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 1.79 Pain Relevance 0.54
To directly examine whether increased levels of leptin can induce degenerative or proinflammatory changes in healthy cartilage, we treated cartilage explants with a range of physiologic doses of leptin, in the presence or absence of IL-1?
Positive_regulation (induce) of Gene_expression (levels) of leptin in cartilage
6) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.60 Pain Relevance 0.25
Osteoarthritis increases the expression of leptin and leptin receptors in chondrocytes [49], suggesting that physiologic levels of leptin may mediate the production of inflammatory mediators in osteoarthritic but not normal tissue.
Spec (may) Positive_regulation (mediate) of Gene_expression (levels) of leptin in chondrocytes associated with inflammatory mediators and osteoarthritis
7) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.65 Pain Relevance 0.25
Osteoarthritis increases the expression of leptin and leptin receptors in chondrocytes [49], suggesting that physiologic levels of leptin may mediate the production of inflammatory mediators in osteoarthritic but not normal tissue.
Positive_regulation (increases) of Gene_expression (expression) of leptin in chondrocytes associated with inflammatory mediators and osteoarthritis
8) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.65 Pain Relevance 0.25
To directly examine whether increased levels of leptin can induce degenerative or proinflammatory changes in healthy cartilage, we treated cartilage explants with a range of physiologic doses of leptin, in the presence or absence of IL-1?
Positive_regulation (increased) of Gene_expression (levels) of leptin in cartilage
9) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.55 Pain Relevance 0.25
Proteoglycan and protein synthesis rates were quantified simultaneously with leptin treatments by measuring the incorporation rates of [35S]sulfate (5 ?
Positive_regulation (simultaneously) of Gene_expression (quantified) of leptin
10) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.10 Pain Relevance 0
Direct administration of leptin into the hippocampus enhances LTP in vivo (Wayner et al., 2004).
Positive_regulation (enhances) of Gene_expression (administration) of leptin in hippocampus associated with long-term potentiation and hippocampus
11) Confidence 0.48 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0.26 Pain Relevance 0.46
For leptin receptor siRNA studies, hippocampal cells (6–7 DIC) were transfected with either EGFP cDNA (1 ?
Positive_regulation (transfected) of Gene_expression (transfected) of leptin associated with disseminated intravascular coagulation
12) Confidence 0.48 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0.17 Pain Relevance 0
Increased circulating leptin levels may explain the reduced grey matter of certain brain areas in obese subjects [133].
Positive_regulation (Increased) of Gene_expression (levels) of leptin in grey matter associated with obesity
13) Confidence 0.45 Published 2009 Journal Scoliosis Section Body Doc Link PMC2781798 Disease Relevance 0.27 Pain Relevance 0.14
Similar to leptin effect on monocytes,it may increase the survival of dendritic cells, and it may also increase the expression of surface molecules, such as CD1a, CD80, CD83, or CD86.
Spec (may) Positive_regulation (increase) of Gene_expression (effect) of leptin in monocytes
14) Confidence 0.44 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.22 Pain Relevance 0.07
However, Zarkesh-Esfahani et al. [43] demonstrated that neutrophils only express the short form of the leptin receptor, which is enough to signal inside the cell, enhancing the expression of CD11b and preventing apoptosis [42, 43].
Positive_regulation (enhancing) of Gene_expression (expression) of leptin in neutrophils associated with apoptosis
15) Confidence 0.44 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.23 Pain Relevance 0.07
The overall leptin action in the immune system is a proinflammatory effect, activating proinflammatory cells, promoting T-helper 1 responses, and mediating the production of the other proinflammatory cytokines, such as tumor necrosis factor-?
Positive_regulation (mediating) of Gene_expression (action) of leptin in immune system associated with necrosis, cancer and cytokine
16) Confidence 0.44 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.41 Pain Relevance 0.15
Increasing leptin levels were significantly associated with severity of hip JSN for either compartment in unadjusted analyses (superior and axial, both P < 0.001) (Figure 1a, Table 2).
Positive_regulation (Increasing) of Gene_expression (levels) of leptin in superior
17) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911879 Disease Relevance 1.33 Pain Relevance 0.13
M), had no effect on the density of filopodia per se (mean density of 2.47 ± 0.56; n = 10; P > 0.05), but it prevented the leptin-induced morphogenesis, such that the mean density of filopodia following exposure to leptin was 2.51 ± 0.62 (n = 11; P > 0.05; Fig. 6C) in neurons incubated with U0126 (1 ?
Positive_regulation (following) of Gene_expression (exposure) of leptin in neurons
18) Confidence 0.41 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0
Furthermore, in OSA with chronic hypercapnia, the leptin levels were even higher.44 Finally, Chin et al45 demonstrated a noticeable reduction in leptin levels following CPAP treatment.45 All these studies propose an important role of leptin and highlight the potential significance of the development of leptin resistance in obesity and OHS.
Positive_regulation (following) of Gene_expression (levels) of leptin associated with obesity, hypercapnia and obesity-hypoventilation syndrome
19) Confidence 0.38 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 1.37 Pain Relevance 0.04
Furthermore, in OSA with chronic hypercapnia, the leptin levels were even higher.44 Finally, Chin et al45 demonstrated a noticeable reduction in leptin levels following CPAP treatment.45 All these studies propose an important role of leptin and highlight the potential significance of the development of leptin resistance in obesity and OHS.
Positive_regulation (following) of Gene_expression (levels) of leptin associated with obesity, hypercapnia and obesity-hypoventilation syndrome
20) Confidence 0.38 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 1.46 Pain Relevance 0.04

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