INT174106

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Context Info
Confidence 0.24
First Reported 2003
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 18
Total Number 21
Disease Relevance 15.82
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Renbp)
Anatomy Link Frequency
corpus callosum 1
brain 1
Renbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 60 99.24 Very High Very High Very High
Pain 37 97.92 Very High Very High Very High
cerebral cortex 6 83.04 Quite High
Somatosensory cortex 15 71.04 Quite High
Inflammation 12 69.04 Quite High
addiction 9 58.64 Quite High
alcohol 6 57.52 Quite High
antiepileptic Drug 2 40.56 Quite Low
carbamazepine 4 38.96 Quite Low
GABAergic 42 34.40 Quite Low
Disease Link Frequency Relevance Heat
Injury 60 99.78 Very High Very High Very High
Birth Weight 60 99.66 Very High Very High Very High
Aging 103 99.56 Very High Very High Very High
Growth Problems 220 99.38 Very High Very High Very High
Uterine Fibroids 564 99.36 Very High Very High Very High
Rheumatoid Arthritis 78 99.24 Very High Very High Very High
Hyperglycemia 6 98.68 Very High Very High Very High
Atherosclerosis 9 98.48 Very High Very High Very High
Chronic Disease 31 98.20 Very High Very High Very High
Vasculitis 11 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Norway, significant interactions (p < 0.01) between sex and age group were detected for visiting a physician and a general practitioner, and in Finland for visiting a physiotherapist.
age Binding (interactions) of
1) Confidence 0.24 Published 2006 Journal BMC Health Serv Res Section Body Doc Link PMC1569836 Disease Relevance 0.14 Pain Relevance 0
There is a significant interaction of the factors age and amplitude for ISIs 35 and 200 ms, indicating that the amplitudes of A1 and A2 diverge as age increases (35 ms: F1,176 = 13.719, P < 0.001; 200 ms: F1,173 = 10.449, P < 0.001).
age Binding (interaction) of
2) Confidence 0.14 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2852507 Disease Relevance 0.07 Pain Relevance 0
Interaction between age and first and second response amplitude is illustrated in Figure 6.


age Binding (Interaction) of
3) Confidence 0.14 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2852507 Disease Relevance 0.05 Pain Relevance 0
There was a significant association between age and all physical subscales (general health, bodily pain, physical functioning and role physical) and with the vitality subscale showing lower scores with higher age.
age Binding (association) of associated with pain
4) Confidence 0.14 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1838413 Disease Relevance 0.60 Pain Relevance 0.21
In addition, to explore the association between age, gender, height, educational level and different aspects of health status of adults with short stature.


age Binding (association) of associated with growth problems
5) Confidence 0.14 Published 2007 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1838413 Disease Relevance 0.92 Pain Relevance 0.04
In addition the association between age, gender, height, educational level and health status of adults with short stature was explored.


age Binding (association) of associated with growth problems
6) Confidence 0.14 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1838413 Disease Relevance 1.30 Pain Relevance 0.10
Within the short stature group there was a significant association between age and all SF-36 physical subcales, height was significantly associated with physical functioning while level of education was significantly associated with mental health.


age Binding (association) of associated with mental disorders and growth problems
7) Confidence 0.14 Published 2007 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1838413 Disease Relevance 1.46 Pain Relevance 0.04
Repeated-measures ANOVA on ratio values with ISIs as the repeated factor and age group as the between-subject factor revealed significant main effects for the factors age (F13,982, P < 0.0001) and ISI (F53,738, P < 0.0001) with no significant age × ISI interaction (F0,979, P = 0.435).
age Binding (group) of
8) Confidence 0.11 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2852507 Disease Relevance 0 Pain Relevance 0.06
An Age at Treatment × Treatment interaction was also found for corpus callosum volume [F(2,57) = 3.2, P < .05], indicating that corpus callosum volumes were smaller as the age of injury decreased from P5 to P1.
Age Binding (interaction) of in corpus callosum associated with injury
9) Confidence 0.09 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2204005 Disease Relevance 0.09 Pain Relevance 0
Other studies of diabetics have shown that alagebrium attenuates both cardiac and renal accumulation of AGEs in association with benefits for patients with renal and cardiac injury.11)15-17) AGE formation may contribute to the progression of atherosclerosis, particularly in those with diabetes.
AGE Binding (formation) of associated with atherosclerosis, diabetes mellitus and injury
10) Confidence 0.07 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 1.14 Pain Relevance 0
Adult aging-related clusters (up-regulated with age: clusters 6, 14, 23; down-regulated with age: clusters 13, 18, 25, 26; Figure 3) from the k-means cluster analysis were selected and their corresponding gene lists were queried for pathways.
age Binding (regulated) of associated with aging
11) Confidence 0.07 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.98 Pain Relevance 0
Not all potential causes of susceptibility were examined, only those gene expression changes associated with sex and age.
age Spec (examined) Binding (associated) of
12) Confidence 0.07 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.18 Pain Relevance 0
Diabetes is closely associated with macrovascular disease.11 Its possible mechanism may involve elevated levels of glucose, resulting in long-term "memory" in the vessel wall, thereby augmenting vascular perturbations.12 A recent report asserted that hyperglycemia leads to the generation and accumulation of AGEs, and that their interaction with the receptor for AGE (RAGE) involves the plausible mechanism of induction of vessel wall memory and sustained perturbation.
AGE Binding (interaction) of associated with hyperglycemia, diabetes mellitus and disease
13) Confidence 0.04 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2823061 Disease Relevance 1.43 Pain Relevance 0
According to these reports, AGE receptor/ligand interaction plays a key role in neointimal formation after vascular injury, irrespective of diabetes status.
AGE Binding (interaction) of associated with diabetes mellitus and vasculitis
14) Confidence 0.04 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2823061 Disease Relevance 1.52 Pain Relevance 0.03
The current findings show that early focal brain injuries, specifically P1 focal freezing necrosis producing microgyria, lead to reductions in brain weight that are so robust that the main effect of Lesion does not interact with Environment, Age, or Sex.
Age Neg (not) Binding (interact) of in brain associated with necrosis and brain injury
15) Confidence 0.02 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC166148 Disease Relevance 0.35 Pain Relevance 0.04
For maternal age, we initially examined associations with 5-year age categories and then further combined categories that were associated with a similar risk of fibroids.
age Spec (examined) Binding (associations) of associated with uterine fibroids
16) Confidence 0.02 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854766 Disease Relevance 0.82 Pain Relevance 0.03
For maternal age, we initially examined associations with 5-year age categories and then further combined categories that were associated with a similar risk of fibroids.
age Spec (examined) Binding (associations) of associated with uterine fibroids
17) Confidence 0.02 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854766 Disease Relevance 0.82 Pain Relevance 0.03
Overall, the age-adjusted and fully adjusted RR estimates for the 14 evaluated exposures were similar, although the association between young maternal age (< 20 years) and fibroids was attenuated in the fully adjusted model.
age Binding (association) of associated with uterine fibroids
18) Confidence 0.02 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854766 Disease Relevance 0.98 Pain Relevance 0
In addition, despite the potential for misclassification bias from self-reported exposure information and fibroid diagnoses, we observed expected associations between specific factors, including a positive association between early age at menarche and fibroids and an increased reporting of maternal preeclampsia among firstborn women and those from a multiple birth (data not shown).


age Binding (association) of associated with uterine fibroids and pre-eclampsia
19) Confidence 0.02 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854766 Disease Relevance 1.01 Pain Relevance 0
Birth weight analyses were repeated with exclusion of women who reported being born at least 1 month early to further our understanding of birth weight and gestational age associations.
age Binding (associations) of associated with birth weight
20) Confidence 0.02 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854766 Disease Relevance 0.81 Pain Relevance 0

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