INT174107

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Context Info
Confidence 0.21
First Reported 2003
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 4
Total Number 15
Disease Relevance 2.95
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Plxna3) intracellular (Plxna3)
Anatomy Link Frequency
brain 2
Plxna3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 66 99.24 Very High Very High Very High
Dopamine 24 91.20 High High
cerebral cortex 12 83.68 Quite High
imagery 12 82.80 Quite High
withdrawal 12 79.36 Quite High
abdominal pain 72 66.64 Quite High
headache 84 65.36 Quite High
backache 21 50.00 Quite Low
depression 12 5.00 Very Low Very Low Very Low
addiction 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 61 99.24 Very High Very High Very High
Necrosis 4 97.66 Very High Very High Very High
Brain Injury 2 96.84 Very High Very High Very High
Low Back Pain 25 95.40 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 876 93.28 High High
Body Weight 24 90.12 High High
Cognitive Disorder 36 82.60 Quite High
Anorexia 48 77.32 Quite High
Weight Loss 24 71.00 Quite High
Abdominal Pain 72 66.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consequently, there were no significant associations for the following variables: Sex, age, severity of pain at base-line, constant pain at base-line, pain turning in bed, problems sleeping, problems putting on socks/shoes, pain on walking, pain on getting up from sitting, and number of "disabilities".


Sex Neg (no) Binding (associations) of associated with pain
1) Confidence 0.21 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2588613 Disease Relevance 1.13 Pain Relevance 1.13
There was no Lesion × Sex interaction (F 2,36 < 1), nor main effect of Sex (F 1,36 <1).


Sex Neg (no) Binding (interaction) of
2) Confidence 0.10 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC166148 Disease Relevance 0.24 Pain Relevance 0
The current findings show that early focal brain injuries, specifically P1 focal freezing necrosis producing microgyria, lead to reductions in brain weight that are so robust that the main effect of Lesion does not interact with Environment, Age, or Sex.
Sex Neg (not) Binding (interact) of in brain associated with necrosis and brain injury
3) Confidence 0.10 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC166148 Disease Relevance 0.35 Pain Relevance 0.04
The lack of consistent treatment-by-sex interactions indicated that both males and females responded well to LDX.
sex Binding (interactions) of
4) Confidence 0.03 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC3022598 Disease Relevance 0 Pain Relevance 0.05
Significant treatment-by-sex interactions were not seen at the majority of time points.
sex Binding (interactions) of
5) Confidence 0.03 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC3022598 Disease Relevance 0 Pain Relevance 0.11
Treatment interaction by age and sex were analyzed, post hoc, among the ITT population using a linear mixed model with sequence, period, sex (or age), treatment, and treatment by sex (or age) defined as fixed effects and subject-within-sequence as the random effect.
sex Binding (interaction) of
6) Confidence 0.03 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC3022598 Disease Relevance 0 Pain Relevance 0
There were significant treatment condition effects for PERMP-A and PERMP-C, and no significant effects of treatment-by-sex interactions were observed at the predose time point (Table 2).
sex Neg (no) Binding (interactions) of
7) Confidence 0.03 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC3022598 Disease Relevance 0 Pain Relevance 0
In addition to the above clinical data, recent studies in animal models [31] and healthy human adults [32] suggest the potential for sex differences in the physiologic response to agents that interact with the dopaminergic system in the brain.
sex Binding (interact) of in brain
8) Confidence 0.02 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC3022598 Disease Relevance 0.21 Pain Relevance 0.12
Treatment-by-sex interactions were observed at time points for SKAMP-D, SKAMP total, and PERMP scores; no consistent pattern across scales or time points was observed.
sex Binding (interactions) of
9) Confidence 0.02 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Abstract Doc Link PMC3022598 Disease Relevance 0.60 Pain Relevance 0.13
For SKAMP-D scores, the only significant treatment-by-sex interaction was seen at the 7.5-hour time point.
sex Binding (interaction) of
10) Confidence 0.02 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC3022598 Disease Relevance 0 Pain Relevance 0
Results of the sex analysis for SKAMP total mirrored those of SKAMP-D with significant effects at all time points and a significant treatment-by-sex interaction at 7.5 and 10 hours postdose.
sex Binding (interaction) of
11) Confidence 0.02 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC3022598 Disease Relevance 0 Pain Relevance 0
For PERMP-A and PERMP-C, no significant effects of sex were seen, although significant treatment-by-sex interactions were seen at 1 time point (10 hours postdose).
sex Binding (interactions) of
12) Confidence 0.02 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC3022598 Disease Relevance 0 Pain Relevance 0
Post hoc analyses assessed interaction between sex or age and treatment and assessed effect sizes for Swanson, Kotkin, Agler, M-Flynn, and Pelham (SKAMP) and Permanent Product Measure of Performance (PERMP) scales and ADHD Rating Scale IV measures.
sex Binding (interaction) of associated with attention deficit hyperactivity disorder
13) Confidence 0.02 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Abstract Doc Link PMC3022598 Disease Relevance 0.35 Pain Relevance 0
For SKAMP-A, significant effects of sex were seen at only 1 time point (10 hours), and no significant treatment-by-sex interactions were observed at any postdose time point.
sex Binding (interactions) of
14) Confidence 0.02 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC3022598 Disease Relevance 0 Pain Relevance 0
The post hoc analyses presented here assessed the efficacy of LDX in female and male participants and in younger (6 to 9 years) and older (10 to 12 years) participants to determine whether sex or age interactions were present.
sex Binding (interactions) of
15) Confidence 0.02 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC3022598 Disease Relevance 0.08 Pain Relevance 0.04

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