INT174116

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Context Info
Confidence 0.31
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.51
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cd1d1) histone binding (Cd1d1) plasma membrane (Cd1d1)
lysosome (Cd1d1) cytoplasm (Cd1d1)
Anatomy Link Frequency
skin 2
Cd1d1 (Mus musculus)
Pain Link Frequency Relevance Heat
psoriasis 22 98.56 Very High Very High Very High
cytokine 6 91.96 High High
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 33 98.56 Very High Very High Very High
Disease 3 64.48 Quite High
Apoptosis 1 39.84 Quite Low
Thyroid Disease 4 5.00 Very Low Very Low Very Low
Graves' Ophthalmopathy 3 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low
Parakeratosis 1 5.00 Very Low Very Low Very Low
Autoimmune Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inability of PTU to reduce CD1a expression in biopsy samples of patients with psoriasis suggests that the mechanism of action of this drug is psoriasis is not due to any effect on skin antigen-presenting cells or production of IL-12, a motive cytokine that is responsible for initiation and maintenance of the cytokine stimulatory cascade that leads to formation of the psoriatic plaque [16].
Negative_regulation (reduce) of Gene_expression (expression) of CD1a in skin associated with psoriasis and cytokine
1) Confidence 0.31 Published 2003 Journal BMC Dermatol Section Body Doc Link PMC169161 Disease Relevance 0.51 Pain Relevance 0.24

General Comments

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