INT174117

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 12.07
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cd1d1) histone binding (Cd1d1) plasma membrane (Cd1d1)
lysosome (Cd1d1) cytoplasm (Cd1d1)
Anatomy Link Frequency
skin 6
dendritic cells 3
liver 2
appendages 2
plaque 2
Cd1d1 (Mus musculus)
Pain Link Frequency Relevance Heat
psoriasis 220 99.92 Very High Very High Very High
chemokine 202 99.68 Very High Very High Very High
Inflammation 132 93.52 High High
cytokine 160 91.96 High High
rheumatoid arthritis 210 91.44 High High
Arthritis 20 59.24 Quite High
cva 13 56.88 Quite High
imagery 110 41.92 Quite Low
agonist 28 27.72 Quite Low
fibrosis 20 26.04 Quite Low
Disease Link Frequency Relevance Heat
Psoriasis 330 99.92 Very High Very High Very High
Thyroid Disease 40 99.28 Very High Very High Very High
Graves' Ophthalmopathy 30 98.94 Very High Very High Very High
Apoptosis 108 98.48 Very High Very High Very High
Cirrhosis 33 98.20 Very High Very High Very High
Rheumatoid Arthritis 212 96.40 Very High Very High Very High
Bordatella Infection 2 95.60 Very High Very High Very High
Hepatitis 187 93.84 High High
INFLAMMATION 144 93.52 High High
Synovitis 12 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Local transforming growth factor beta may play a role in the maintaining DC in an immature state or in the upregulation of CD1a expression [97].
Gene_expression (expression) of CD1a
1) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206384 Disease Relevance 0.61 Pain Relevance 0.18
In synovial tissue the immature DC are characterized by CCR6 and CD1a expression, and in nodules by CMRF-44 and CD14 expression [11,96].
Gene_expression (expression) of CD1a in nodules
2) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206384 Disease Relevance 0.61 Pain Relevance 0.18
CD1d is expressed on hepatocytes, Kupffer cells, hepatic dendritic cells, and sinusoid-lining endothelial cells (see Figure 3C), all of which have been demonstrated to have significant antigen-uptake capabilities [1].
Gene_expression (expressed) of CD1d in dendritic cells
3) Confidence 0.50 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.22 Pain Relevance 0.03
Using flow cytometry, we observed that sinusoid-lining endothelial cells (CD31+ cells and Tie2+ cells) express high levels of CD1d on their surface, and Kupffer cells (F4/80+) and dendritic cells (CD11c-high cells) express lower, but clearly detectable, levels of surface CD1d (Figure 3C).
Gene_expression (express) of CD1d in dendritic cells
4) Confidence 0.44 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.06 Pain Relevance 0.03
Equal numbers of CD1d-?
Gene_expression (numbers) of CD1d
5) Confidence 0.43 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.24 Pain Relevance 0
The number of GFPhi CD1d-?
Gene_expression (number) of CD1d
6) Confidence 0.43 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.17 Pain Relevance 0
The pattern suggests high expression on hepatocytes, including an intracellular peri-nuclear compartment, but whether other cell types also express CD1d was difficult to assess by this method.
Gene_expression (express) of CD1d in hepatocytes
7) Confidence 0.43 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0 Pain Relevance 0
Consistent with this observation, Annexin V staining of CD1d-reactive GFPhi cells isolated from liver indicated that cxcr6gfp/gfp cells underwent apoptosis more rapidly than cxcr6gfp/+ cells (Figure 5C).
Gene_expression (staining) of CD1d in liver associated with apoptosis
8) Confidence 0.43 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.49 Pain Relevance 0
GalCer) presented by CD1d.
Gene_expression (presented) of CD1d
9) Confidence 0.43 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.69 Pain Relevance 0.06
The number of GFPhi CD1d-?
Gene_expression (number) of CD1d
10) Confidence 0.43 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.20 Pain Relevance 0
Our study shows that CXCR6, which is expressed on CD1d-reactive NKT cells, controls the selective accumulation of these cells in the liver.
Gene_expression (expressed) of CD1d in liver
11) Confidence 0.43 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.24 Pain Relevance 0.11
Staining of liver sections with antibody specific for activated caspase-3 showed only 1%–2% apoptotic cells among GFPhi cells in cxcr6gfp/+ and cxcr6gfp/gfp mice, and Annexin V staining of CD1d-reactive GFPhi cells by flow cytometry gave similar results (data not shown).
Gene_expression (staining) of CD1d in apoptotic cells associated with apoptosis
12) Confidence 0.43 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.44 Pain Relevance 0
The inability of PTU to reduce CD1a expression in biopsy samples of patients with psoriasis suggests that the mechanism of action of this drug is psoriasis is not due to any effect on skin antigen-presenting cells or production of IL-12, a motive cytokine that is responsible for initiation and maintenance of the cytokine stimulatory cascade that leads to formation of the psoriatic plaque [16].
Gene_expression (expression) of CD1a in skin associated with psoriasis and cytokine
13) Confidence 0.41 Published 2003 Journal BMC Dermatol Section Body Doc Link PMC169161 Disease Relevance 0.51 Pain Relevance 0.24
CD1a expression is not pronounced in the precursors and is not significantly expressed until the cells become differentiated.[35-38] Differentiated cells localize to the midepidermis, demonstrate characteristic Birbeck granules, and exhibit dendritic appendages.
Neg (not) Gene_expression (expressed) of CD1a in appendages
14) Confidence 0.41 Published 2003 Journal BMC Dermatol Section Body Doc Link PMC169161 Disease Relevance 0.47 Pain Relevance 0.25
CD1a expression is not pronounced in the precursors and is not significantly expressed until the cells become differentiated.[35-38] Differentiated cells localize to the midepidermis, demonstrate characteristic Birbeck granules, and exhibit dendritic appendages.
Gene_expression (expression) of CD1a in appendages
15) Confidence 0.41 Published 2003 Journal BMC Dermatol Section Body Doc Link PMC169161 Disease Relevance 0.46 Pain Relevance 0.22
Using flow cytometry, we observed that sinusoid-lining endothelial cells (CD31+ cells and Tie2+ cells) express high levels of CD1d on their surface, and Kupffer cells (F4/80+) and dendritic cells (CD11c-high cells) express lower, but clearly detectable, levels of surface CD1d (Figure 3C).
Gene_expression (express) of CD1d in endothelial cells
16) Confidence 0.39 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0 Pain Relevance 0.03
Clinical response to PTU as assessed by PASI scores, histological changes after treatment, and CD1a expression in lesional skin before and after treatment were studied.


Gene_expression (expression) of CD1a in skin
17) Confidence 0.31 Published 2003 Journal BMC Dermatol Section Abstract Doc Link PMC169161 Disease Relevance 0.70 Pain Relevance 0.20
CD1a expression in psoriatic skin following treatment with propylthiouracil, an antithyroid thioureylene

Background

Gene_expression (expression) of CD1a in skin associated with psoriasis
18) Confidence 0.31 Published 2003 Journal BMC Dermatol Section Title Doc Link PMC169161 Disease Relevance 0.75 Pain Relevance 0.20
CD1a is expressed in differentiated antigen-presenting cells and monocytes and is used as a marker for the presence of these cells in the skin[24-26].
Gene_expression (expressed) of CD1a in skin
19) Confidence 0.31 Published 2003 Journal BMC Dermatol Section Body Doc Link PMC169161 Disease Relevance 0.93 Pain Relevance 0.20
Expression of CD1a in Psoriatic Plaques
Gene_expression (Expression) of CD1a in Plaques associated with psoriasis
20) Confidence 0.31 Published 2003 Journal BMC Dermatol Section Body Doc Link PMC169161 Disease Relevance 0.36 Pain Relevance 0.09

General Comments

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