INT17414

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Context Info
Confidence 0.47
First Reported 1991
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TRH, Prl) signal transduction (TRH) plasma membrane (TRH)
nucleus (TRH) cell-cell signaling (TRH) cytoplasm (TRH)
TRH (Homo sapiens)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 2 99.24 Very High Very High Very High
halothane 28 98.16 Very High Very High Very High
opiate 1 97.48 Very High Very High Very High
antagonist 1 97.20 Very High Very High Very High
narcan 4 85.00 Quite High
headache 3 10.00 Low Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 3 2 50.00 Quite Low
Dizziness 1 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Heart Rate Under Development 1 5.00 Very Low Very Low Very Low
Headache 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Halothane, at concentrations used to produce general anesthesia in animals (0.25-0.76 mM), inhibited thyrotropin-releasing hormone (TRH)-induced prolactin (PRL) secretion.
TRH Positive_regulation (induced) of prolactin associated with anesthesia and halothane
1) Confidence 0.47 Published 1991 Journal J. Neurosci. Section Abstract Doc Link 1906092 Disease Relevance 0 Pain Relevance 0.42
Halothane, at concentrations used to produce general anesthesia in animals (0.25-0.76 mM), inhibited thyrotropin-releasing hormone (TRH)-induced prolactin (PRL) secretion.
thyrotropin-releasing hormone Positive_regulation (induced) of prolactin associated with anesthesia and halothane
2) Confidence 0.47 Published 1991 Journal J. Neurosci. Section Abstract Doc Link 1906092 Disease Relevance 0 Pain Relevance 0.42
The plants product induced a significant increase in Prl and TSH response to TRH.
TRH Positive_regulation (increase) of Prl
3) Confidence 0.19 Published 1998 Journal Minerva Ginecol Section Body Doc Link 9677811 Disease Relevance 0 Pain Relevance 0
Similarly, TRH-induced PRL response was not significantly affected by the infusion of an opiate antagonist.
TRH Positive_regulation (induced) of PRL associated with antagonist and opiate
4) Confidence 0.19 Published 1996 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 8750573 Disease Relevance 0 Pain Relevance 0.23

General Comments

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