INT174155

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.77
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome segregation (Brca1) intracellular (Brca1) enzyme binding (Brca1)
DNA binding (Brca1) protein complex (Brca1) ligase activity (Brca1)
Brca1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 11 95.80 Very High Very High Very High
tolerance 7 51.92 Quite High
Inflammation 17 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 139 99.16 Very High Very High Very High
Cancer 222 95.44 Very High Very High Very High
Disease 33 88.40 High High
Pox Virus Infection 11 82.20 Quite High
Recurrence 9 75.76 Quite High
Ovarian Cancer 6 69.20 Quite High
Non-small-cell Lung Cancer 3 64.24 Quite High
Genomic Instability 4 60.88 Quite High
Metastasis 17 58.96 Quite High
Neurodegenerative Disease 14 56.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in patient cells with MCPH1 truncating mutations no downregulation of BRCA1 and CHK1 was observed [13].
Neg (no) Negative_regulation (downregulation) of BRCA1
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.33 Pain Relevance 0
A recent study of BRCA1/2 mutations in young breast cancer patients (age 36 or less)201 showed that carriers of BRCA1/2 mutations had a ?
Negative_regulation (carriers) of BRCA1 associated with breast cancer
2) Confidence 0.27 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.59 Pain Relevance 0
More specifically, there was no significant reduction in the expression levels of Chk1, Brca1, Topbp1, Rad51, Ddb2, p73, Apaf1, or caspases which were all described to show reduced expression following MCPH1 knockdowns [34] (Tables S3, S4, S5).
Neg (no) Negative_regulation (reduction) of Brca1
3) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.11 Pain Relevance 0
Replacing defective genes (p53, BRCA1, RB, p16) [35, 38]
Negative_regulation (Replacing) of BRCA1
4) Confidence 0.07 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.74 Pain Relevance 0.07

General Comments

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