INT174156

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Context Info
Confidence 0.72
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 13.52
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Anatomy Link Frequency
ND3 2
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 76 99.44 Very High Very High Very High
Inflammation 114 98.94 Very High Very High Very High
tolerance 10 92.00 High High
Osteoarthritis 36 89.28 High High
Central nervous system 6 82.56 Quite High
metalloproteinase 10 76.04 Quite High
imagery 70 66.24 Quite High
cytokine 37 62.96 Quite High
cINOD 16 61.44 Quite High
Bioavailability 1 58.16 Quite High
Disease Link Frequency Relevance Heat
Cancer 693 100.00 Very High Very High Very High
Meningioma 182 100.00 Very High Very High Very High
Ovarian Cancer 105 99.84 Very High Very High Very High
Apoptosis 139 99.50 Very High Very High Very High
Rheumatoid Arthritis 76 99.44 Very High Very High Very High
INFLAMMATION 129 98.94 Very High Very High Very High
Dna Damage 1 98.80 Very High Very High Very High
Retinoblastoma 3 98.46 Very High Very High Very High
Neurofibromatosis 2 18 96.64 Very High Very High Very High
Breast Cancer 32 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chemically damaged cells undergo a p53-dependent apoptotic pathway that involves upregulation of p53 transcripts such as the pro-apoptotic Bcl2 family members and p53 translocation to the mitochondria, resulting in neutralization of the anti-apoptotic members Bcl-xL and Bcl-2 [26].
Localization (translocation) of p53 associated with apoptosis
1) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 1.10 Pain Relevance 0
The tissue from patient 1946 exhibited positive nuclear staining for p53 (Figure 2D) in contrast to that observed with the tumor from the patient 2223 (Figure 2H). p53 positive immunoreactivity was mirrored in the cell lines by western blot (Figure 2I).


Localization (staining) of p53 associated with cancer
2) Confidence 0.69 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.68 Pain Relevance 0
Amplified products of P53short, P53long, ND3, and SRY loci were run on a gel: 5 ?
Localization (loci) of P53short in ND3
3) Confidence 0.48 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2266725 Disease Relevance 0 Pain Relevance 0
The p16INK4a/p14ARF locus encodes two distinct cell cycle inhibitory proteins, p16INK4a and p14ARF (p19Arf in the mouse) by alternative first-exon usage and alternative reading frames (20). p16INK4a arrests cells in the G1 phase of the cell cycle by binding the cyclin-dependant kinases CDK4 and CDK6 and inhibiting their ability to phosphorylate and inactivate the retinoblastoma (RB1) family of tumor suppressor proteins (22). p14ARF acts through MDM2 to stabilize and activate the key checkpoint protein p53, which can arrest cells in both G1 and G2 or induce apoptosis (20).
Localization (stabilize) of p53 associated with cancer, apoptosis and retinoblastoma
4) Confidence 0.44 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.27 Pain Relevance 0
Deletion of the p16INK4a/p14ARF locus is found in both benign and malignant meningiomas, while mutation of the p53 tumor suppressor gene is uncommon.
Localization (found) of p53 associated with meningioma and cancer
5) Confidence 0.41 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Abstract Doc Link PMC2253711 Disease Relevance 1.56 Pain Relevance 0.11
Over-expression of MIF down regulated p53 levels and suppressed nuclear localization, thereby prohibiting its transcriptional activity.
Localization (localization) of p53
6) Confidence 0.27 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.30 Pain Relevance 0.17
As well as its established role in inflammation, MIF directly promotes tumourigenesis by inhibiting p53 accumulation.
Localization (accumulation) of p53 associated with inflammation
7) Confidence 0.26 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.50 Pain Relevance 0.22
Amplified products of P53short, P53long, ND3, and SRY loci were run on a gel: 5 ?
Localization (loci) of P53long in ND3
8) Confidence 0.21 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2266725 Disease Relevance 0 Pain Relevance 0
A recent study [9] used mouse EOC cells (deletion of p53, or overexpression of c-myc/K-ras or c-myc/Akt) to demonstrate increased expression of COX-1 in these genetically engineered EOC cells.
Localization (deletion) of p53 associated with ovarian cancer
9) Confidence 0.11 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.74 Pain Relevance 0
They observed translocation of p53 to the nuclei in cells that overexpressed PTTG1.
Localization (translocation) of p53
10) Confidence 0.11 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.36 Pain Relevance 0.10
Over 900 patients have been treated by gene transfer products (nonreplication-selective AdV p53, Aventis Pharma) over a period of 5 years.
Localization (selective) of p53
11) Confidence 0.10 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.64 Pain Relevance 0.08
The effect of TUSC2 on chemosensitivity was associated with down-regulation of MDM2, accumulation of p53, and activation of the Apaf-1 apoptotic pathway [22].
Localization (accumulation) of p53 associated with apoptosis
12) Confidence 0.09 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2776015 Disease Relevance 1.38 Pain Relevance 0.15
Effective degradation of p53 is mediated by the ubiquitin ligase Mdm2, as well as in RA [47], and Mdm2 can promote p53 deacetylation by recruiting a complex containing HDAC1 [48].
Localization (deacetylation) of p53 associated with rheumatoid arthritis
13) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.20 Pain Relevance 0.33
The p53 tumor suppressor, encoded by a commonly mutated gene in human cancers, can positively and negatively regulate autophagy depending on its localization.
Localization (localization) of p53 associated with cancer
14) Confidence 0.07 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.56 Pain Relevance 0
Targeted genes could be Ku (releasing BAX), STAT3, HSP90, p53, and various transcription factors.
Localization (releasing) of p53
15) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.17 Pain Relevance 0.03
-tubulin (target of HDAC6) and p53.
Localization (target) of p53
16) Confidence 0.05 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.05 Pain Relevance 0

General Comments

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