INT174160

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.24
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 12.61
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12a) extracellular region (Il12a) cytoplasm (Il12a)
Anatomy Link Frequency
T cells 3
NK cell 2
monocyte 1
Th1 cell 1
dendritic cells 1
Il12a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 543 100.00 Very High Very High Very High
Inflammation 280 100.00 Very High Very High Very High
psoriasis 112 98.96 Very High Very High Very High
Spinal cord 7 98.32 Very High Very High Very High
rheumatoid arthritis 16 97.92 Very High Very High Very High
chemokine 55 96.44 Very High Very High Very High
imagery 9 94.96 High High
Pain 12 89.84 High High
Central nervous system 121 87.80 High High
methotrexate 12 85.64 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 323 100.00 Very High Very High Very High
Splenomegaly 5 99.92 Very High Very High Very High
Cold Sores 1074 99.84 Very High Very High Very High
Infection 1216 99.80 Very High Very High Very High
Cancer 565 99.28 Very High Very High Very High
Psoriasis 138 98.96 Very High Very High Very High
Influenza Virus Infection 20 98.52 Very High Very High Very High
Disease 287 98.00 Very High Very High Very High
Rheumatoid Arthritis 16 97.92 Very High Very High Very High
Pox Virus Infection 17 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, recipients of IL-12–modulated cells preferentially up-regulated the monocyte- and lymphocyte-attracting ELR?
IL-12 Binding (recipients) of in monocyte
1) Confidence 0.24 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 0.81 Pain Relevance 0.52
IL-23 is a heterodimeric protein composed of a p19 subunit and a p40 subunit, whereas IL-12, an important cytokine for Th1 cell differentiation, is formed when the p40 subunit dimerizes with p35 (8).
p35 Binding (dimerizes) of in Th1 cell associated with cytokine
2) Confidence 0.19 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 0.93 Pain Relevance 0.59
IL-12 was first described as an NK cell stimulatory factor (NKSF) and identified as a heterodimeric molecule composed of a p40 and a p35 subunit, which are covalently linked [233].
p35 Binding (linked) of in NK cell
3) Confidence 0.19 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.11 Pain Relevance 0.08
The effect of IL-12 in HSV infections seems to be conducted in synergy with IL-18 [390], as it has also been shown for vaccinia virus [392].
IL-12 Binding (effect) of associated with pox virus infection, cold sores and infection
4) Confidence 0.19 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 1.70 Pain Relevance 0
The receptor for IL-12 is found on NK cells, T cells and dendritic cells and consists of two subunits (?
IL-12 Binding (receptor) of in T cells
5) Confidence 0.19 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.26 Pain Relevance 0
It is suggested that certain genetic alteration of the IL-23 (p40 and p19) or IL-12 (p40 and p35) subunits as well as the IL-23 receptor or its ligand will lead to enhanced IL-23 production and subsequent psoriasis susceptibility.
IL-12 Binding (alteration) of associated with psoriasis
6) Confidence 0.16 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.02 Pain Relevance 0.51
Both IL-12 and IL-23 have been associated with the pathogenesis of psoriasis, in part due to their relationship to the differentiation of naïve T-cells into Th1 and Th17 cells5,6 (Figure 1).
IL-12 Binding (associated) of in T-cells associated with psoriasis
7) Confidence 0.15 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.24 Pain Relevance 0.69
Briefly, four dilutions of single cell suspensions were overlaid on 96-well Immunolon H2B plates coated with antibodies to IL-12, IL-6 (BD Pharmingen, San Diego, CA), TNF?
IL-12 Binding (coated) of
8) Confidence 0.10 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1156963 Disease Relevance 0.12 Pain Relevance 0.07
After incubation, supernatants were harvested and assayed for secreted IL-12 and IL-10 by commercial ELISA kits (Biosource International, CA, USA).
IL-12 Binding (assayed) of
9) Confidence 0.09 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.32 Pain Relevance 0
, IL-12, and/or TNF-?
IL-12 Binding (/) of
10) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731172 Disease Relevance 0.96 Pain Relevance 0.19
Furthermore, the inability of IL-12p40, IL-12p35, and IFN-?
IL-12p35 Binding (inability) of
11) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731172 Disease Relevance 1.05 Pain Relevance 0.10
AS Bcl-2 ODNs induced splenomegaly in association with increased serum IL-12, which was attenuated by methylation of the CpG motifs of AS Bcl-2; however, methylated CpG failed to negate the increased antitumor effect of AS Bcl-2.
IL-12 Binding (association) of associated with splenomegaly
12) Confidence 0.07 Published 2005 Journal Breast Cancer Res Section Abstract Doc Link PMC1410745 Disease Relevance 0.36 Pain Relevance 0
Mice injected with IL-12 expressing adenovirus achieved significant survival advantage compared to controls.


IL-12 Binding (injected) of
13) Confidence 0.07 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 1.15 Pain Relevance 0
The receptor for IL-12 is found on NK cells, T cells and dendritic cells and consists of two subunits (?
IL-12 Binding (receptor) of in NK cells
14) Confidence 0.07 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.26 Pain Relevance 0
The receptor for IL-12 is found on NK cells, T cells and dendritic cells and consists of two subunits (?
IL-12 Binding (receptor) of in dendritic cells
15) Confidence 0.07 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.26 Pain Relevance 0
Preclinical evaluation showed increased efficacy when administered in association with either radiotherapy, Cisplatin, or cytokines such as IL-12, GM-CSF, or the costimulatory molecule B7.1 [47, 48, 49].
IL-12 Binding (association) of associated with cytokine
16) Confidence 0.06 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 1.06 Pain Relevance 0.10
Likewise, the proinflammatory interleukins, IL-7, IL-15, IL-12, IL1-?
IL-12 Binding (interleukins) of
17) Confidence 0.05 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.39 Pain Relevance 0.19
Resistance to T. cruzi infection has been associated with the production of the pro-inflammatory cytokines IL-12 and IFN-?
IL-12 Binding (associated) of associated with inflammation, infection and cytokine
18) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.62 Pain Relevance 0.18
After this second signal, the T cells become activated, and APCs begin to secrete important cytokines, including IL-12 and IL-23, which bind to specific receptors on T cells and drive them to secrete different cytokines, such as IFN-?
IL-12 Binding (bind) of in T cells associated with cytokine
19) Confidence 0.03 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox