INT17417

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Context Info
Confidence 0.69
First Reported 1991
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 18
Disease Relevance 24.29
Pain Relevance 2.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 3
skin 2
joint 1
erythrocyte 1
immune system 1
Ighd (Mus musculus)
Pain Link Frequency Relevance Heat
headache 13 99.54 Very High Very High Very High
Arthritis 14 99.32 Very High Very High Very High
Inflammation 21 99.12 Very High Very High Very High
backache 1 94.72 High High
Pain 5 93.04 High High
fibrosis 2 91.84 High High
abdominal pain 8 89.36 High High
cytokine 6 79.36 Quite High
rheumatoid arthritis 5 77.84 Quite High
Inflammatory response 1 75.20 Quite High
Disease Link Frequency Relevance Heat
Borrelia Infection 5 99.96 Very High Very High Very High
Syndrome 156 99.92 Very High Very High Very High
Leukocytosis 13 99.88 Very High Very High Very High
Anaemia 11 99.84 Very High Very High Very High
Familial Mediterranean Fever 39 99.66 Very High Very High Very High
Fever 118 99.56 Very High Very High Very High
Headache 13 99.54 Very High Very High Very High
Arthritis 17 99.32 Very High Very High Very High
INFLAMMATION 27 99.12 Very High Very High Very High
Arthralgia 22 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Familial Mediterranean Fever: association of elevated IgD plasma levels with specific MEFV mutations.
Positive_regulation (elevated) of IgD in plasma associated with familial mediterranean fever
1) Confidence 0.69 Published 2001 Journal Eur. J. Hum. Genet. Section Title Doc Link 11781702 Disease Relevance 0.91 Pain Relevance 0.14
Elevated IgD plasma levels are also correlated with the severity of FMF manifestations, and especially with arthritis.
Positive_regulation (Elevated) of IgD in plasma associated with familial mediterranean fever and arthritis
2) Confidence 0.69 Published 2001 Journal Eur. J. Hum. Genet. Section Abstract Doc Link 11781702 Disease Relevance 0.48 Pain Relevance 0.09
IgD and IgA levels were elevated in three out of four patients.
Positive_regulation (elevated) of IgD
3) Confidence 0.67 Published 2006 Journal Scand. J. Gastroenterol. Section Body Doc Link 16635911 Disease Relevance 0.07 Pain Relevance 0
The hyperimmunoglobulinemia D and periodic fever (hyper-IgD) syndrome is typified by recurrent febrile attacks with abdominal distress, joint involvement (arthralgias/arthritis), headache, skin lesions, and an elevated serum IgD level (> 100 U/ml).
Positive_regulation (elevated) of IgD in skin associated with arthralgia, hypergammaglobulinemia, syndrome, headache, fever and arthritis
4) Confidence 0.64 Published 1994 Journal Hum. Genet. Section Abstract Doc Link 7989036 Disease Relevance 1.38 Pain Relevance 0.15
Serum immunoelectrophoresis revealed M-protein of IgD and serum IgD level remarkably increased to 5420 mg/dl.
Positive_regulation (increased) of IgD
5) Confidence 0.60 Published 1991 Journal Rinsho Ketsueki Section Abstract Doc Link 1906116 Disease Relevance 1.03 Pain Relevance 0.18
Thus, homozygotic status for M694V, and to a lesser extent V726A, is associated with increased risk for higher IgD plasma levels, regardless of colchicine use.
Positive_regulation (increased) of IgD in plasma
6) Confidence 0.50 Published 2001 Journal Eur. J. Hum. Genet. Section Abstract Doc Link 11781702 Disease Relevance 0.35 Pain Relevance 0.09
Serum IgD was found elevated (>100 U/mL) in 12 of the 18 patients tested (140.2 +/- 62.4 U/mL).
Positive_regulation (elevated) of IgD
7) Confidence 0.36 Published 1999 Journal J. Pediatr. Section Abstract Doc Link 10393612 Disease Relevance 1.62 Pain Relevance 0.18
The hyper-IgD syndrome (HIDS) is a rare autosomal recessive inflammatory disorder characterized by recurrent fever, increased serum IgD (normal value < 100 U/ml) and generalized inflammation (lymphadenopathy, arthralgias/arthritis, abdominal complaints, skin rash, and headache).
Positive_regulation (increased) of IgD in skin associated with exanthema, arthralgia, inflammation, lymphadenopathy, syndrome, headache, borrelia infection and arthritis
8) Confidence 0.34 Published 2004 Journal Reumatismo Section Abstract Doc Link 15470520 Disease Relevance 1.80 Pain Relevance 0.32
They were positive for CD 5, 19, 20, 22, 23, HLA-DR, IgM, IgD and kappa chain.
Positive_regulation (positive) of IgD
9) Confidence 0.23 Published 2002 Journal Rinsho Ketsueki Section Abstract Doc Link 12229129 Disease Relevance 0.75 Pain Relevance 0.06
All patients had a persistently elevated serum IgD level (> 100 U/mL), and in 82% of cases the serum IgA was likewise elevated.
Positive_regulation (elevated) of IgD
10) Confidence 0.21 Published 1994 Journal Medicine (Baltimore) Section Abstract Doc Link 8190036 Disease Relevance 1.77 Pain Relevance 0.23
The vast majority of DPF patients have persistently elevated serum IgD and can be classified as having hyperimmunoglobulinemia D and periodic fever syndrome (HIDS).
Positive_regulation (elevated) of IgD associated with hypergammaglobulinemia, syndrome and fever
11) Confidence 0.18 Published 2000 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 10949735 Disease Relevance 2.40 Pain Relevance 0.15
All patients have an elevated serum IgD (> 100 U/ml).
Positive_regulation (elevated) of IgD
12) Confidence 0.16 Published 1995 Journal Presse Med Section Abstract Doc Link 7567850 Disease Relevance 0.98 Pain Relevance 0.22
All patients had a persistently elevated serum IgD level (> 100 U/mL), and in 82% of cases the serum IgA was likewise elevated.
Positive_regulation (elevated) of IgD
13) Confidence 0.15 Published 1994 Journal Medicine (Baltimore) Section Abstract Doc Link 8190036 Disease Relevance 1.72 Pain Relevance 0.24
Laboratory investigations reveal elevated acute phase reactants (erythrocyte sedimentation rate, C-reactive protein, leukocytosis) and elevated immunoglobulins, including IgA, IgE and especially IgD.
Positive_regulation (elevated) of IgD in erythrocyte associated with leukocytosis
14) Confidence 0.09 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1475558 Disease Relevance 2.78 Pain Relevance 0.06
Elevations of IgD, IgA and urinary leukotriene E4 excretion are probably secondary to stimulation of the immune system [27].


Positive_regulation (Elevations) of IgD in immune system
15) Confidence 0.08 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1475558 Disease Relevance 1.41 Pain Relevance 0.22
Increased levels of immunoglobulin D (IgD) and, in most patients of immunoglobulin A (IgA), in combination with enhanced excretion of mevalonic acid provide strong evidence for HIDS.
Positive_regulation (Increased) of IgD associated with syndrome
16) Confidence 0.07 Published 2006 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1475558 Disease Relevance 2.21 Pain Relevance 0
The hyperimmunoglobulinemia D and periodic fever (hyper-IgD) syndrome is typified by recurrent febrile attacks with abdominal distress, joint involvement (arthralgias/arthritis), headache, skin lesions, and an elevated serum IgD level (> 100 U/mL).
Positive_regulation (elevated) of IgD in joint associated with arthralgia, hypergammaglobulinemia, syndrome, headache, fever and arthritis
17) Confidence 0.05 Published 1995 Journal Blood Section Abstract Doc Link 7780142 Disease Relevance 1.12 Pain Relevance 0.28
Studies have measured immunoglobulin (Ig) levels in the sera of FMF patients and found elevated levels of IgA, IgM, IgG, and IgD in 23%, 13%, 17% and 13%, respectively.
Positive_regulation (elevated) of IgD associated with familial mediterranean fever
18) Confidence 0.05 Published 2004 Journal Sante Section Abstract Doc Link 15745878 Disease Relevance 1.53 Pain Relevance 0.18

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