INT174188

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 6.22
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RB1) DNA binding (RB1) nucleus (RB1)
molecular_function (RB1) cell division (RB1) cellular_component (RB1)
Anatomy Link Frequency
macrophages 4
RB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 14 84.56 Quite High
Dismenorea 7 80.00 Quite High
agonist 7 76.72 Quite High
cytokine 29 72.24 Quite High
Inflammation 67 71.88 Quite High
Kinase C 49 66.88 Quite High
withdrawal 28 52.32 Quite High
Inflammatory stimuli 7 29.64 Quite Low
tolerance 7 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Papillomavirus Infection 12 100.00 Very High Very High Very High
Infection 145 99.58 Very High Very High Very High
Mycobacterial Infection 4 99.38 Very High Very High Very High
Cancer 145 99.10 Very High Very High Very High
Breast Cancer 15 97.24 Very High Very High Very High
Apoptosis 276 96.92 Very High Very High Very High
Death 12 94.72 High High
Airway Obstruction 1 87.04 High High
Gonorrhea 2 85.92 High High
INFLAMMATION 89 84.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B induction of PRB expression through protein kinase A and CCAAT/enhancer-binding protein (CEBP) and PRA expression indirectly through MAP kinase and AP-1 activation (Figure 6).


Positive_regulation (through) of Gene_expression (expression) of PRB
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.43 Pain Relevance 0.30
B activation led to an increase in PRA and PRB mRNA and protein expression.
Positive_regulation (increase) of Gene_expression (expression) of PRB
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.15 Pain Relevance 0
B activation PRA protein increased 14 fold above baseline (Figure 1A and 1B); PRB mRNA and protein expression increased 4.2 fold (Figure 2A and 2B respectively).
Positive_regulation (increased) of Gene_expression (expression) of PRB
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.25 Pain Relevance 0
B activation on myometrial PRA, PRB or ER alpha expression.
Positive_regulation (activation) of Gene_expression (expression) of PRB
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.53 Pain Relevance 0.13
B induction of PRB expression through protein kinase A and CCAAT/enhancer-binding protein (CEBP) and PRA expression indirectly through MAP kinase and AP-1 activation (Figure 6).


Positive_regulation (induction) of Gene_expression (expression) of PRB
5) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.42 Pain Relevance 0.28
B activation on myometrial PRA, PRB or ER alpha expression.
Positive_regulation (myometrial) of Gene_expression (expression) of PRB
6) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.52 Pain Relevance 0.13
B activation leads to an increase in Cox2 mRNA levels from 0.00054 mM at pre-labor to 0.28 ┬ÁM at labor, and a 15 fold increase in PRA expression and a 4.2 fold increase in PRB expression with labor.
Positive_regulation (increase) of Gene_expression (expression) of PRB
7) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.39 Pain Relevance 0.10
M. tuberculosis infection of epithelial cells results in increased expression of BCL2 and pRb, decreased expression of BAX and BAD, and no change in p53 expression despite a large increase in expression of p53 in infected macrophages.
Positive_regulation (results) of Gene_expression (expression) of pRb in macrophages associated with mycobacterial infection and infection
8) Confidence 0.12 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 1.25 Pain Relevance 0
M. tuberculosis infection of epithelial cells results in increased expression of BCL2 and pRb, decreased expression of BAX and BAD, and no change in p53 expression despite a large increase in expression of p53 in infected macrophages.
Positive_regulation (increased) of Gene_expression (expression) of pRb in macrophages associated with mycobacterial infection and infection
9) Confidence 0.08 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 1.25 Pain Relevance 0
While overall approximately 50% of tumour cells are defective in the p53 pathway, it is estimated that one hundred percent of tumour cells present one of several defects in the Rb pathway, the most prevalent being p16 mutations, cyclin D amplification, HPV E7 overexpression, or a defective Rb expression itself.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Rb associated with papillomavirus infection and cancer
10) Confidence 0.03 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 1.03 Pain Relevance 0

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