INT174189

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 12.58
Pain Relevance 4.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (E2F2) nucleus (E2F2) DNA binding (E2F2)
transcription factor binding (E2F2)
Anatomy Link Frequency
H69 2
vein 1
E2F2 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 1040 99.30 Very High Very High Very High
Inflammation 72 95.36 Very High Very High Very High
cytokine 52 94.32 High High
COX2 2 86.28 High High
antagonist 1 37.12 Quite Low
tolerance 28 35.04 Quite Low
metalloproteinase 17 5.00 Very Low Very Low Very Low
imagery 15 5.00 Very Low Very Low Very Low
cINOD 14 5.00 Very Low Very Low Very Low
Chronic pancreatitis 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epstein-barr Virus 92 100.00 Very High Very High Very High
Infection 48 100.00 Very High Very High Very High
Small Cell Lung Cancer 504 99.86 Very High Very High Very High
Cancer 900 99.84 Very High Very High Very High
Fatigue 40 99.24 Very High Very High Very High
Retinoblastoma 53 98.38 Very High Very High Very High
Apoptosis 117 95.44 Very High Very High Very High
INFLAMMATION 78 95.36 Very High Very High Very High
Starvation 8 90.88 High High
Increased Venous Pressure Under Development 5 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Next, we wanted to examine whether capsaicin-induced growth arrest was correlated with any changes in the expression of E2F-target proliferative genes.
Gene_expression (expression) of E2F associated with qutenza
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.19 Pain Relevance 0.85
E2F1, E2F2, E2F3, E2F4, E2F5 and E2F6 siRNAs were individually transfected in H69 cells.
Gene_expression (transfected) of E2F2 in H69
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.59 Pain Relevance 0.82
Furthermore, capsaicin-induced growth arrest was associated with a decrease in the expression of the E2F target genes cyclin E, TS, cdc25A and cdc6.
Gene_expression (expression) of E2F associated with qutenza
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.71 Pain Relevance 0.93
After 36 hours of transfection, lysates were made as described above and the expression of E2F family of proteins was determined by western blotting analysis.


Gene_expression (expression) of E2F
4) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.09 Pain Relevance 0
Several genes including ISG20 (interferon stimulated gene), DNAJB2 (DnaJ [Hsp40] homolog and CD99), CDK8 (cyclin-dependent kinase 8), E2F2 (E2F transcription factor 2), CDK8 (cyclin-dependent kinase 8), and ACTN2 (actinin, alpha 2), known to be regulated during EBV infection, were differentially expressed in post-infective fatigue cases.
Gene_expression (expressed) of E2F transcription factor 2 associated with fatigue, epstein-barr virus and infection
5) Confidence 0.43 Published 2006 Journal BMC Infect Dis Section Abstract Doc Link PMC1373655 Disease Relevance 1.05 Pain Relevance 0
Several genes including ISG20 (interferon stimulated gene), DNAJB2 (DnaJ [Hsp40] homolog and CD99), CDK8 (cyclin-dependent kinase 8), E2F2 (E2F transcription factor 2), CDK8 (cyclin-dependent kinase 8), and ACTN2 (actinin, alpha 2), known to be regulated during EBV infection, were differentially expressed in post-infective fatigue cases.
Gene_expression (expressed) of E2F2 associated with fatigue, epstein-barr virus and infection
6) Confidence 0.43 Published 2006 Journal BMC Infect Dis Section Abstract Doc Link PMC1373655 Disease Relevance 1.05 Pain Relevance 0
Control H69 SCLC cells contained E2F1, E2F2 and E2F3 bound to proliferative promoters.
Gene_expression (contained) of E2F2 in H69 associated with small cell lung cancer
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.57 Pain Relevance 0.31
Chemically synthesized, double-stranded siRNA for E2F1, E2F2, E2F3, E2F4, E2F5 and E2F6 was purchased from Santa Cruz Biotechnology.
Gene_expression (synthesized) of E2F2
8) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0 Pain Relevance 0
We found that the anti-proliferative activity of capsaicin is correlated with a decrease in the expression of E2F-responsive proliferative genes like cyclin E, thymidylate synthase, cdc25A and cdc6, both at mRNA and protein levels.
Gene_expression (expression) of E2F associated with qutenza
9) Confidence 0.38 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2857654 Disease Relevance 0.66 Pain Relevance 0.89
These observations seemed to suggest that the anti-proliferative effect of capsaicin was correlated with a decrease in levels of E2F responsive S-phase genes in vivo.


Gene_expression (levels) of E2F associated with qutenza
10) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.74 Pain Relevance 0.78
inhibition of E2F/DP DNA binding [129], the inhibition of cyclins D1 and E,
Gene_expression (/) of E2F
11) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.29 Pain Relevance 0.14
Phosphorylation of Rb on specific Cdk-consensus sites results in the dissociation of protein complexes between Rb, histone deacetylases (HDACs), and E2F transcription factors and allows for the expression of E2F-responsive genes that drive progression through G1 and entry into the S-phase of the cell cycle [64].
Gene_expression (expression) of E2F associated with retinoblastoma
12) Confidence 0.03 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0.96 Pain Relevance 0
Tumour cells have high levels of free E2F and therefore genes that have E2F responsive elements (E1A, TS, TK, dhfr, E2F itself etc.) should be more highly expressed in tumour cells.
Gene_expression (expressed) of E2F associated with cancer
13) Confidence 0.02 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 1.16 Pain Relevance 0
Tumour cells have high levels of free E2F and therefore genes that have E2F responsive elements (E1A, TS, TK, dhfr, E2F itself etc.) should be more highly expressed in tumour cells.
Gene_expression (expressed) of E2F associated with cancer
14) Confidence 0.02 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 1.14 Pain Relevance 0
Another recombinant adenovirus vector in which p53-dependent expression of a fusion protein (E2F-Rb) selectively attenuated viral replication in normal cells, was further modified by insertion of the viral late promoter (MLP) in the E3 region with the aim of driving overexpression of Ad5-E3 11.6K protein, thereby increasing cytotoxicity in tumour cells, while decreasing cytotoxicity in normal cells.
Gene_expression (expression) of E2F associated with cancer
15) Confidence 0.02 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.79 Pain Relevance 0
Tumour cells have high levels of free E2F and therefore genes that have E2F responsive elements (E1A, TS, TK, dhfr, E2F itself etc.) should be more highly expressed in tumour cells.
Gene_expression (expressed) of E2F associated with cancer
16) Confidence 0.02 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 1.15 Pain Relevance 0
Importantly, in a clinical trial using ex vivo E2F decoy oligodeoxynucleotide transfection of human vein grafts, Mann et al [42] have shown this strategy to reduce proliferation and hence the occurrence of vein graft occlusion.
Gene_expression (transfection) of E2F in vein
17) Confidence 0.01 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 0.67 Pain Relevance 0
On the other hand, many researchers have found that transcription factors (e.g., c-Myb, c-Myc/Myn, E2F, CREB, Ap1, Ap2, Sp1, and NF-?
Gene_expression (/) of E2F
18) Confidence 0.01 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2862018 Disease Relevance 0.24 Pain Relevance 0
B is required for cell proliferation by mediating the expression of c-Myc [24], which stimulates the transcription of genes with an important role in cell cycle control, like cyclins, CDKs and E2F [25].
Gene_expression (expression) of E2F
19) Confidence 0.01 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.53 Pain Relevance 0

General Comments

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