INT174190

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.99
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TKT) small molecule metabolic process (TKT) nucleolus (TKT)
peroxisome (TKT) nucleus (TKT) carbohydrate metabolic process (TKT)
TKT (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 64 60.80 Quite High
tolerance 14 37.68 Quite Low
imagery 33 36.40 Quite Low
Inflammation 43 5.00 Very Low Very Low Very Low
Central nervous system 21 5.00 Very Low Very Low Very Low
Pain 16 5.00 Very Low Very Low Very Low
positron emission tomography 12 5.00 Very Low Very Low Very Low
Nerve growth factor 10 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
Peripheral nervous system 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 460 99.64 Very High Very High Very High
Hepatocellular Cancer 7 98.84 Very High Very High Very High
Liver Failure 2 96.68 Very High Very High Very High
Toxicity 28 95.40 Very High Very High Very High
Liver Cancer 2 94.56 High High
Cytomegalovirus Infection 4 92.68 High High
Cold Sores 367 84.60 Quite High
Pancreatic Cancer 3 82.00 Quite High
Suicidal Behaviour 5 78.64 Quite High
Breast Cancer 20 75.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The likelihood of TK transmission is affected by work patterns, which influences the amount of time an individual spends in the natural environment performing agricultural work.
Regulation (affected) of Gene_expression (transmission) of TK
1) Confidence 0.43 Published 2008 Journal J Ethnobiol Ethnomed Section Body Doc Link PMC2275234 Disease Relevance 0 Pain Relevance 0
In vivo, the expression of autologous tk gene in association with GCV was shown to be highly efficient in both reducing small tumour masses growth rates and also in inhibiting tumour cell engraftment.
Regulation (efficient) of Gene_expression (expression) of tk associated with cancer
2) Confidence 0.10 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.89 Pain Relevance 0.03
occurred following TK expression in nontumour cells, emphasized the need to target the expression of the tk gene to tumor cells using a hepatoma-specific promoter such as AFP
Regulation (target) of Gene_expression (expression) of tk associated with cancer and hepatocellular cancer
3) Confidence 0.05 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 1.21 Pain Relevance 0
TK gene expression has been placed under the control of the alpha-fetoprotein promoter to enhance specificity for HCC cells and to diminish tk/gancyclovir toxicity to normal cells.
Regulation (under) of Gene_expression (expression) of TK associated with toxicity
4) Confidence 0.05 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.89 Pain Relevance 0

General Comments

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