INT174193

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Context Info
Confidence 0.28
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 12.65
Pain Relevance 5.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (LILRA3) extracellular region (LILRA3) plasma membrane (LILRA3)
Anatomy Link Frequency
fat cells 2
plasma 1
LILRA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 612 99.32 Very High Very High Very High
Osteoarthritis 441 99.04 Very High Very High Very High
Inflammatory response 4 92.60 High High
Inflammation 190 88.68 High High
cINOD 58 83.92 Quite High
Leflunomide 45 83.52 Quite High
depression 16 68.88 Quite High
tolerance 8 50.64 Quite High
sSRI 4 33.84 Quite Low
Glutamate receptor 2 22.52 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 612 99.32 Very High Very High Very High
Obesity 18 99.16 Very High Very High Very High
Frailty 450 99.04 Very High Very High Very High
Cancer 275 97.96 Very High Very High Very High
Disease 224 94.72 High High
INFLAMMATION 195 92.20 High High
Disorder Of Lipid Metabolism 4 87.56 High High
Shock 16 86.68 High High
Head & Neck Cancer 8 80.56 Quite High
Pre-eclampsia 100 80.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, levels of E2, E3, and 16?
Gene_expression (levels) of E3
1) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257423 Disease Relevance 1.55 Pain Relevance 0.77
Interestingly, using testosterone as the substrate led to small amounts of produced E3 and 16?
Gene_expression (produced) of E3
2) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257423 Disease Relevance 0.51 Pain Relevance 0.44
-dihydrotestosterone tended to inhibit production of combined E3 and 16?
Gene_expression (production) of E3
3) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257423 Disease Relevance 0.53 Pain Relevance 0.39
-dihydro-ASD, testosterone, and negligible amounts of E1, E2, E3, and 16?
Gene_expression (amounts) of E3
4) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257423 Disease Relevance 0.37 Pain Relevance 0.29
-dihydro-ASD, testosterone, and negligible amounts of E1, E2, E3, or 16?
Gene_expression (amounts) of E3
5) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257423 Disease Relevance 1.67 Pain Relevance 0.84
Typically serum levels of E3 in non-pregnant women and men are below 7,000 pmol/l [27].
Gene_expression (levels) of E3
6) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257423 Disease Relevance 1.06 Pain Relevance 0.44
Interestingly, levels of testosterone were similar as compared with E2, combined E3 and 16?
Gene_expression (compared) of E3
7) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257423 Disease Relevance 0.68 Pain Relevance 0.46
OH-DHEA, testosterone, estrone (E1), estradiol (E2), estriol (E3), and 16?
Gene_expression (estriol) of E3
8) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257423 Disease Relevance 1.49 Pain Relevance 0.74
Interestingly, levels of testosterone were similar as compared with E2, combined E3 and 16?
Gene_expression (combined) of E3
9) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257423 Disease Relevance 0.67 Pain Relevance 0.46
The primary physiological estrogens (E1, E2, and E3) are predominantly synthesized in the ovaries, though they can also be synthesized in placenta (especially E3),62 brain,63,64 and fat cells.65 The levels of these hormones are therefore affected by the quantity and state of such non ovarian tissues.
Gene_expression (synthesized) of E3 in fat cells associated with obesity
10) Confidence 0.14 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0.35 Pain Relevance 0.09
The expression of a transgene in the E3 region is regulated under the control of endogenous viral late gene regulatory elements and linked with the replication of oncolytic Ad (Royds et al 2006).


Gene_expression (expression) of E3
11) Confidence 0.11 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761194 Disease Relevance 0.60 Pain Relevance 0
The primary physiological estrogens (E1, E2, and E3) are predominantly synthesized in the ovaries, though they can also be synthesized in placenta (especially E3),62 brain,63,64 and fat cells.65 The levels of these hormones are therefore affected by the quantity and state of such non ovarian tissues.
Gene_expression (synthesized) of E3 in fat cells associated with obesity
12) Confidence 0.10 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0.34 Pain Relevance 0.09
In order to examine which lysine linkage utilized by HSP70 binds to p62’s UBA domain, in vitro ubiquitination assay was performed by incubating lysates from HEK cells expressing HSP70 with E1, E2, and E3 in reaction buffer (50 mM Tris-HCl pH 7.5, 2.5 mM MgCl2, 2 mM DTT, 2 mM ATP).
Gene_expression (expressing) of E3
13) Confidence 0.06 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0.09 Pain Relevance 0
TRAF6 was chosen as an E3 in this in vitro ubiquitination assay due to its RING domain, a common feature of E3 ligases, and the observation that p62 is a scaffold for TRAF6 interaction (46).
Gene_expression (ligases) of E3
14) Confidence 0.06 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0.06 Pain Relevance 0
The APOE gene on chromosome 19 has 3 common alleles, encoding 3 plasma ApoE isoforms, e2, e3, and e4.
Gene_expression (isoforms) of e3 in plasma
15) Confidence 0.06 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 1.11 Pain Relevance 0.05
thousand E3 enzymes, which ensure a high degree of substrate specificity to the
Gene_expression (enzymes) of E3
16) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0.05 Pain Relevance 0
-OHE hydroxylation, and has itself, along with its other metabolites, been implicated in possible carcinogenic activity, in animal models.25 Non-detectable levels of E3, added to non-detectable levels of 2-OHE and/or 4-OHE and/or 16?
Gene_expression (levels) of E3
17) Confidence 0.04 Published 2010 Journal Breast Cancer (Auckl) Section Body Doc Link PMC3018890 Disease Relevance 0.38 Pain Relevance 0
Another recombinant adenovirus vector in which p53-dependent expression of a fusion protein (E2F-Rb) selectively attenuated viral replication in normal cells, was further modified by insertion of the viral late promoter (MLP) in the E3 region with the aim of driving overexpression of Ad5-E3 11.6K protein, thereby increasing cytotoxicity in tumour cells, while decreasing cytotoxicity in normal cells.
Gene_expression (overexpression) of E3 associated with cancer
18) Confidence 0.03 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.84 Pain Relevance 0.03
If a specific E3 mediates the ubiquitination and degradation of a PSD protein, then that PSD protein should accumulate to higher levels when expression of the endogenous E3 is suppressed by RNAi.
Gene_expression (expression) of E3
19) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0.23 Pain Relevance 0
For the 2003 data and the reduced-form logistic regression model, eigenvectors E1, E7, E12 and E26 account for roughly 40% of the variance in the intercept DFBETA statistic, as do eigenvectors E3, E7, E18, E27 and E29 for the indicator variable DFBETA statistic.
Gene_expression (account) of E3
20) Confidence 0.01 Published 2005 Journal Int J Health Geogr Section Body Doc Link PMC1215506 Disease Relevance 0.06 Pain Relevance 0

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