INT174194

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Context Info
Confidence 0.33
First Reported 2003
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 13
Disease Relevance 2.05
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CSF1) cell proliferation (CSF1) extracellular space (CSF1)
extracellular region (CSF1) plasma membrane (CSF1)
Anatomy Link Frequency
chondrocytes 10
CSF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Snapping jaw 88 81.72 Quite High
cytokine 81 80.88 Quite High
Inflammation 82 80.24 Quite High
Hyperalgesia 11 70.92 Quite High
Pain 24 70.24 Quite High
metalloproteinase 12 62.36 Quite High
Osteoarthritis 77 50.00 Quite Low
tolerance 7 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 130 100.00 Very High Very High Very High
Metastasis 5 84.56 Quite High
Temporomandibular Joint Syndrome 88 81.72 Quite High
Arthropathy 45 81.28 Quite High
INFLAMMATION 84 80.24 Quite High
Renal Cancer 2 80.20 Quite High
Osteoporosis 27 79.44 Quite High
Hypercalcemia 29 77.92 Quite High
Hyperalgesia 11 70.92 Quite High
Breast Cancer 8 70.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-mediated reduction in M-CSF expression.
Negative_regulation (reduction) of Gene_expression (expression) of M-CSF
1) Confidence 0.33 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.05 Pain Relevance 0
, whereas M-CSF expression decreased.
Negative_regulation (decreased) of Gene_expression (expression) of M-CSF
2) Confidence 0.33 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.24 Pain Relevance 0.12
 ; whereas M-CSF expression decreased.
Negative_regulation (decreased) of Gene_expression (expression) of M-CSF
3) Confidence 0.24 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
suppresses the formation of osteoclast-like cells via increased OPG production and decreased M-CSF production in chondrocytes, and OPG production may increase through an autocrine mechanism involving celecoxib-related PGs.


1.

Negative_regulation (decreased) of Gene_expression (production) of M-CSF in chondrocytes
4) Confidence 0.24 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
and/or celecoxib, a specific inhibitor of COX-2 [24, 25], on the expression of M-CSF, RANKL, and OPG in human chondrocytes, and the indirect effect of IL-1?
Negative_regulation (effect) of Gene_expression (expression) of M-CSF in chondrocytes
5) Confidence 0.24 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.51 Pain Relevance 0.39
suppresses the formation of osteoclast-like cells via an increase in OPG production and a decrease in M-CSF production, at least in part, in the human chondrocytes used in this study, and that OPG production may increase through an autocrine mechanism involving celecoxib-related PGs.
Negative_regulation (decrease) of Gene_expression (production) of M-CSF in chondrocytes
6) Confidence 0.24 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.07 Pain Relevance 0
Consistent with the results obtained in the gene expression study, M-CSF protein expression was significantly lower in the presence of IL-1?
Negative_regulation (lower) of Gene_expression (expression) of M-CSF
7) Confidence 0.24 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
Despite this general decreasing trend, M-CSF gene expression was consistently lower in IL-1?
Negative_regulation (lower) of Gene_expression (expression) of M-CSF
8) Confidence 0.24 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
and celecoxib, a specific inhibitor of COX-2 [24, 25], on the expression of M-CSF, RANKL, and OPG in human chondrocytes, and the indirect effect of IL-1?
Negative_regulation (inhibitor) of Gene_expression (expression) of M-CSF in chondrocytes
9) Confidence 0.24 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.13 Pain Relevance 0.10
stimulation, whereas M-CSF expression decreased (data not shown).
Negative_regulation (decreased) of Gene_expression (expression) of M-CSF
10) Confidence 0.24 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.05 Pain Relevance 0.03
not only affected the expression of RANKL, M-CSF, and OPG in chondrocytes, but may also affect the course of cell differentiation.
Negative_regulation (affected) of Gene_expression (expression) of M-CSF in chondrocytes
11) Confidence 0.24 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
Moreover, in the control (untreated) specimens and in the absence of M-CSF, the TRAP staining level was reduced by 25% compared with the level in the presence of M-CSF.
Negative_regulation (reduced) of Neg (absence) Gene_expression (absence) of M-CSF
12) Confidence 0.24 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.08 Pain Relevance 0.03
CSF-1 expression by tumours is
Negative_regulation (is) of Gene_expression (expression) of CSF-1 associated with cancer
13) Confidence 0.08 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.93 Pain Relevance 0.14

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