INT174195

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 11.98
Pain Relevance 3.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-E)
Anatomy Link Frequency
bone marrow 2
T cells 2
CD86 1
leukocyte 1
monocytes 1
HLA-E (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 53 99.84 Very High Very High Very High
chemokine 28 99.72 Very High Very High Very High
tolerance 14 99.72 Very High Very High Very High
aspirin 328 99.62 Very High Very High Very High
Inflammation 186 98.76 Very High Very High Very High
cINOD 133 98.56 Very High Very High Very High
cytokine 208 97.92 Very High Very High Very High
addiction 6 93.24 High High
Inflammatory response 8 91.40 High High
metalloproteinase 104 77.72 Quite High
Disease Link Frequency Relevance Heat
Cancer 582 100.00 Very High Very High Very High
Demyelinating Disease 59 99.84 Very High Very High Very High
Bullous Skin Disease 106 99.00 Very High Very High Very High
Chlamydia Infection 88 98.90 Very High Very High Very High
INFLAMMATION 221 98.76 Very High Very High Very High
Disease 214 98.40 Very High Very High Very High
Aging 104 97.12 Very High Very High Very High
Disease Susceptibility 12 97.08 Very High Very High Very High
Acute Generalized Exanthematous Pustulosis 7 96.84 Very High Very High Very High
Autoimmune Disease 47 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conserved MHC blocks and CEHs have been shown to represent markers of human diversity and/or disease susceptibility [4].
Negative_regulation (blocks) of MHC associated with disease susceptibility
1) Confidence 0.42 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0.10 Pain Relevance 0
MHC haplotype blocks and the larger CEHs are usually inherited intact as a unit, and the allele frequency distribution of particular MHC locus combinations in individuals is non-random [1-7].
Negative_regulation (blocks) of MHC
2) Confidence 0.42 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0
It is also well recognized that CEHs may be represented as a higher order of association, through successive generations, of four or more defined MHC blocks, showing a stronger linkage disequilibrium (LD) to that expected by random recombination.
Negative_regulation (blocks) of MHC
3) Confidence 0.42 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0
W6/32 is a prototypic anti-MHC class I antibody that binds to a conformational epitope on MHCI heavy chains upon their association with ?
Negative_regulation (epitope) of MHC in W6/32
4) Confidence 0.41 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
In both the Hap2 and Hap3-only subsets, we observed a possible depletion of high MHC similarity in mate pairs relative to non-mate pairs (Figure 2).
Spec (possible) Negative_regulation (depletion) of MHC
5) Confidence 0.39 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2861700 Disease Relevance 0 Pain Relevance 0
Through breakdown of LD between MHC blocks, we once again infer recombination breakpoints on either side of HLA-E.
Negative_regulation (blocks) of MHC
6) Confidence 0.37 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0
Unlike the effect of nonMHC-d2, this effect was mainly driven by allelic diversity (d2) at one locus, D6S2883.
Negative_regulation (effect) of nonMHC
7) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712076 Disease Relevance 0.51 Pain Relevance 0
In addition, there was also a small independent effect of MHC-d2 on health after controlling for the effect of nonMHC-d2, with individuals with greater MHC-d2 reporting fewer symptoms.
Negative_regulation (effect) of nonMHC
8) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712076 Disease Relevance 0.07 Pain Relevance 0
Despite the loss of significance for MHC dissimilarity in the 24 Hap2?
Negative_regulation (loss) of MHC
9) Confidence 0.28 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2861700 Disease Relevance 0 Pain Relevance 0
Therefore, reduced MHC class I levels may result in a lower presentation of rare antigens (particularly, in this case, of those preferentially trimmed by ERAP2), possibly delaying their specific immune response.
Negative_regulation (reduced) of MHC
10) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.37 Pain Relevance 0.05
In addition, the apparent depletion of very high MHC identity coefficients among mates (Figure S2) hints that mate selection may disfavor extreme MHC similarity.
Negative_regulation (depletion) of MHC
11) Confidence 0.25 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2861700 Disease Relevance 0 Pain Relevance 0.05
7) from the interleukin-2 receptor (IL2R) gene making this the second non-MHC locus to be established in multiple sclerosis (IMSGC, 2007).
Negative_regulation (established) of non-MHC in IL2R associated with multiple sclerosis
12) Confidence 0.21 Published 2008 Journal Brain Section Body Doc Link PMC2639203 Disease Relevance 0.31 Pain Relevance 0.11
These difficulties include a lack of major histocompatibility complex (MHC) and autoantibody associations in many diseases, tentatively labelled as autoimmune.
Negative_regulation (lack) of MHC associated with disease
13) Confidence 0.20 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1564298 Disease Relevance 1.06 Pain Relevance 0.12
The reduced MHC class I cell-surface expression might be due to reduced stability of the MHC complex when loaded with suboptimal peptides, as has been suggested with ERAP1-deficient mice [55], [56], [62].
Negative_regulation (reduced) of MHC
14) Confidence 0.20 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.43 Pain Relevance 0.03
Because we studied a natural deficiency of ERAP2, our results suggest that the observed reduction in MHC class I levels is not transient and that BB-homozygotes likely have lower background levels of MHC presentation.
Negative_regulation (reduction) of MHC
15) Confidence 0.20 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.45 Pain Relevance 0.04
The reduced MHC class I cell-surface expression might be due to reduced stability of the MHC complex when loaded with suboptimal peptides, as has been suggested with ERAP1-deficient mice [55], [56], [62].
Negative_regulation (reduced) of MHC
16) Confidence 0.20 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.37 Pain Relevance 0
Because T cells can only recognize antigens presented in the form of short peptide-MHC complexes presented by professional antigen presenting cells (22-25), inhibition of the MHC-restricted antigen presenting function of DCs by ibuprofen might have had significant effects in activating T cells.
Negative_regulation (inhibition) of MHC in T cells
17) Confidence 0.08 Published 2010 Journal Immune Network Section Body Doc Link PMC2902675 Disease Relevance 0 Pain Relevance 0.07
In summary, we have demonstrated that aspirin and ibuprofen at high concentrations inhibit both MHC class I and class II-restricted exogenous antigen presentation.
Negative_regulation (inhibit) of MHC associated with aspirin
18) Confidence 0.08 Published 2010 Journal Immune Network Section Body Doc Link PMC2902675 Disease Relevance 0.08 Pain Relevance 0.13
Aspirin and ibuprofen at high concentrations inhibited both MHC class I and class II-restricted presentation of OVA in DCs.
Negative_regulation (inhibited) of MHC in DCs associated with aspirin
19) Confidence 0.06 Published 2010 Journal Immune Network Section Abstract Doc Link PMC2902675 Disease Relevance 0.30 Pain Relevance 0.70
Among these are the genes “pirated” from the host or cellular homologues like viral G-protein-coupled receptor (vGPCR), vIL-6, viral interferon regulatory factors (vIRFs 1-4), viral chemokines (vCCLs 1-3), MHC class I down-regulating E3 ligases K3 and K5 (MIR1 and MIR2), and Kaposin B [13],[14],[15],[16],[17],[18],[19].
Negative_regulation (down-regulating) of MHC class I down-regulating E3 associated with chemokine
20) Confidence 0.06 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.18 Pain Relevance 0.27

General Comments

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