INT174197

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RB1) DNA binding (RB1) nucleus (RB1)
molecular_function (RB1) cell division (RB1) cellular_component (RB1)
RB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 5.00 Very Low Very Low Very Low
cytokine 22 5.00 Very Low Very Low Very Low
tolerance 14 5.00 Very Low Very Low Very Low
Opioid 13 5.00 Very Low Very Low Very Low
narcan 9 5.00 Very Low Very Low Very Low
opioid receptor 8 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Enkephalin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Papillomavirus Infection 75 100.00 Very High Very High Very High
Retinoblastoma 26 100.00 Very High Very High Very High
Cancer 338 99.10 Very High Very High Very High
Basal And Squamous Cell Skin Cancer 71 95.88 Very High Very High Very High
Infection 17 94.00 High High
Airway Obstruction 2 87.04 High High
Toxicity 14 84.28 Quite High
Non-small-cell Lung Cancer 6 82.40 Quite High
Bladder Cancer 2 79.56 Quite High
Metastasis 10 71.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of total Rb protein was not decreased from baseline values after 21 hours of OGF treatment using an antibody at 1:200 dilution.
Neg (not) Negative_regulation (decreased) of Gene_expression (Expression) of Rb associated with retinoblastoma
1) Confidence 0.47 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.88 Pain Relevance 0
The HPV viral gene products E6 and E7 interact with host cell p53 and Rb proteins, resulting in p53 dysfunction and inactivation of Rb, respectively.
Negative_regulation (inactivation) of Gene_expression (dysfunction) of Rb associated with papillomavirus infection
2) Confidence 0.06 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3003991 Disease Relevance 1.37 Pain Relevance 0
While overall approximately 50% of tumour cells are defective in the p53 pathway, it is estimated that one hundred percent of tumour cells present one of several defects in the Rb pathway, the most prevalent being p16 mutations, cyclin D amplification, HPV E7 overexpression, or a defective Rb expression itself.
Negative_regulation (defective) of Gene_expression (expression) of Rb associated with papillomavirus infection and cancer
3) Confidence 0.04 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.96 Pain Relevance 0
While overall approximately 50% of tumour cells are defective in the p53 pathway, it is estimated that one hundred percent of tumour cells present one of several defects in the Rb pathway, the most prevalent being p16 mutations, cyclin D amplification, HPV E7 overexpression, or a defective Rb expression itself.
Negative_regulation (defective) of Gene_expression (expression) of Rb associated with papillomavirus infection and cancer
4) Confidence 0.03 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 1.04 Pain Relevance 0

General Comments

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