INT17421

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Context Info
Confidence 0.57
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 41
Total Number 41
Disease Relevance 15.23
Pain Relevance 10.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Anatomy Link Frequency
eosinophils 3
heart 3
macrophage 1
bone marrow 1
leukocyte 1
Alox5 (Mus musculus)
Pain Link Frequency Relevance Heat
licofelone 18 99.84 Very High Very High Very High
Kinase C 3 99.80 Very High Very High Very High
Inflammation 278 99.78 Very High Very High Very High
Potency 3 99.74 Very High Very High Very High
Analgesic 36 99.72 Very High Very High Very High
cINOD 72 99.48 Very High Very High Very High
COX2 21 99.06 Very High Very High Very High
Pain 24 98.42 Very High Very High Very High
aspirin 10 98.20 Very High Very High Very High
Hyperalgesia 8 97.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 124 99.98 Very High Very High Very High
Pressure And Volume Under Development 54 99.90 Very High Very High Very High
INFLAMMATION 305 99.78 Very High Very High Very High
Nociception 2 99.30 Very High Very High Very High
Toxicity 4 98.60 Very High Very High Very High
Adhesions 15 97.84 Very High Very High Very High
Hyperalgesia 9 97.36 Very High Very High Very High
Urological Neuroanatomy 16 97.28 Very High Very High Very High
Malignant Neoplastic Disease 2 96.76 Very High Very High Very High
Atherosclerosis 5 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The analgetic activity of inhibitors of 5-lipoxygenase (5-LO) and cyclooxygenase (CO) was investigated using rat Randall-Selitto (RS) hyperalgesia and mouse phenylbenzoquinone (PBQ)-induced abdominal constriction assays.
Negative_regulation (inhibitors) of 5-LO associated with hyperalgesia
1) Confidence 0.57 Published 1991 Journal Agents Actions Suppl. Section Abstract Doc Link 1906235 Disease Relevance 0.24 Pain Relevance 0.24
Research on dual inhibitors of both 5-LOX and COXs gained interest due to the overexpressions of these enzymes during the malignant state of the evolution of prostate cancer.
Negative_regulation (inhibitors) of 5-LOX associated with malignant neoplastic disease and reprotox - general 1
2) Confidence 0.48 Published 2010 Journal Bioorg. Med. Chem. Section Abstract Doc Link 20451397 Disease Relevance 0.32 Pain Relevance 0.08
In contrast to the observed effects of aging in brain tissue, we found that in heart tissue aging was associated with a decrease in 5-LOX mRNA content.
Negative_regulation (decrease) of 5-LOX in heart associated with aging
3) Confidence 0.47 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.83 Pain Relevance 0.10
In contrast to indomethacin, which inhibits cyclooxygenase, neither nordihydroguaiaretic acid, an inhibitor of the lipoxygenase pathway, nor eicosa-5,8,11,14-tetraynoic acid, an inhibitor of both the cyclooxygenase and the lipoxygenase pathways, had this augmenting effect.
Negative_regulation (inhibitor) of lipoxygenase
4) Confidence 0.45 Published 1982 Journal Immunopharmacology Section Abstract Doc Link 6211419 Disease Relevance 0.08 Pain Relevance 0.08
BW755C, a drug that inhibits both cyclooxygenase and lipoxygenase, dramatically inhibited eosinophil accumulation at 25 to 125 mg/kg.
Negative_regulation (inhibits) of lipoxygenase in eosinophil
5) Confidence 0.42 Published 1983 Journal J. Immunol. Section Abstract Doc Link 6401785 Disease Relevance 0.07 Pain Relevance 0.12
Thus, the novel 5-LOX/COX and (*)OH inhibitor 11a possesses anti-inflammatory activity that, in addition to COX/5-LOX inhibition, implicates effects on leukocyte-endothelial interactions.
Negative_regulation (inhibition) of 5-LOX in leukocyte associated with inflammation
6) Confidence 0.42 Published 2009 Journal Bioorg. Med. Chem. Section Abstract Doc Link 19097798 Disease Relevance 0.87 Pain Relevance 0.36
The current lead 11a was evaluated in COX-1/2, 5-LOX and (*)OH scavenging in vitro assays and in a static adhesion assay where it proved to inhibit adhesion.
Negative_regulation (evaluated) of 5-LOX associated with adhesions
7) Confidence 0.41 Published 2009 Journal Bioorg. Med. Chem. Section Abstract Doc Link 19097798 Disease Relevance 0.87 Pain Relevance 0.41
In contrast to indomethacin, which inhibits cyclooxygenase, neither nordihydroguaiaretic acid, an inhibitor of the lipoxygenase pathway, nor eicosa-5,8,11,14-tetraynoic acid, an inhibitor of both the cyclooxygenase and the lipoxygenase pathways, had this augmenting effect.
Negative_regulation (inhibitor) of lipoxygenase
8) Confidence 0.37 Published 1982 Journal Immunopharmacology Section Abstract Doc Link 6211419 Disease Relevance 0.08 Pain Relevance 0.08
Aging decreased 5-LOX mRNA content in the heart and increased it in the brain.
Negative_regulation (decreased) of 5-LOX in heart associated with aging
9) Confidence 0.35 Published 2009 Journal Neural Plasticity Section Abstract Doc Link PMC2801004 Disease Relevance 0.42 Pain Relevance 0
However, in the heart, aging resulted in significantly decreased 5-LOX mRNA levels (Figure 3).
Negative_regulation (decreased) of 5-LOX in heart associated with aging
10) Confidence 0.35 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.35 Pain Relevance 0.03
The experimental system described may be used for assessing the potency of drugs to inhibit the lipoxygenase and the cyclooxygenase pathway of arachidonic acid metabolism.
Negative_regulation (inhibit) of lipoxygenase associated with potency
11) Confidence 0.34 Published 1985 Journal Int J Tissue React Section Abstract Doc Link 3928518 Disease Relevance 0.13 Pain Relevance 0.12
The experimental system described may be used for assessing the potency of drugs to inhibit the lipoxygenase and the cyclooxygenase pathway of arachidonic acid metabolism.
Negative_regulation (inhibit) of lipoxygenase associated with potency
12) Confidence 0.34 Published 1984 Journal Agents Actions Section Abstract Doc Link 6433678 Disease Relevance 0.15 Pain Relevance 0.28
Furthermore, the results suggested that dual inhibitors of cyclooxygenase and lipoxygenase like licofelone provide an effective control of inflammation and hyperalgesia against acute inflammation/hyperalgesia in rats and mice.
Negative_regulation (inhibitors) of lipoxygenase associated with hyperalgesia, inflammation and licofelone
13) Confidence 0.33 Published 2006 Journal Fundam Clin Pharmacol Section Abstract Doc Link 16448396 Disease Relevance 0.90 Pain Relevance 1.21
It may be anticipated from these results that drugs inhibiting lipoxygenase will have critical effects on manifestations of immunologic reactions that recruit eosinophils.
Negative_regulation (inhibiting) of lipoxygenase in eosinophils
14) Confidence 0.31 Published 1983 Journal J. Immunol. Section Abstract Doc Link 6401785 Disease Relevance 0.07 Pain Relevance 0.11
Pretreatment in vitro of 111In-labeled eosinophils with some drugs known to inhibit lipoxygenase reduced their subsequent accumulation at a lymphokine-injected site in vivo, but the high concentrations required for inhibition suggested that the effects of the drugs were at least partially reversible.
Negative_regulation (inhibit) of lipoxygenase in eosinophils
15) Confidence 0.31 Published 1983 Journal J. Immunol. Section Abstract Doc Link 6401785 Disease Relevance 0.07 Pain Relevance 0.12
Lysosomal hydrolytic enzymes as well as 5'-lipoxygenase activities were reduced by the agents.
Negative_regulation (reduced) of lipoxygenase
16) Confidence 0.30 Published 1996 Journal Int J Tissue React Section Abstract Doc Link 9063766 Disease Relevance 0.42 Pain Relevance 0.31
Moreover, some alkaloids isolated from the leaf of Alstonia scholaris exhibited inhibition of COX-1, COX-2 and 5-LOX in vitro anti-inflammatory assay, which supported alkaloids as the bioactive fraction.
Negative_regulation (inhibition) of 5-LOX in leaf
17) Confidence 0.26 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 20219658 Disease Relevance 0 Pain Relevance 0
In in vitro tests, alkaloids exhibited inhibition of inflammatory mediators (COX-1, COX-2 and 5-LOX), which is accordant with results on animal models.
Negative_regulation (inhibition) of 5-LOX
18) Confidence 0.26 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 20219658 Disease Relevance 0 Pain Relevance 0
Naturally occurring biflavonoid, ochnaflavone, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.
Negative_regulation (inhibits) of 5-lipoxygenase in bone marrow associated with cox2
19) Confidence 0.21 Published 2006 Journal Arch. Pharm. Res. Section Title Doc Link 16681032 Disease Relevance 0 Pain Relevance 0.11
The macrophage plays a major role in the immune response and the inflammatory process, it has the capacity to synthesize and secrete arachidonic acid oxygenation products derived from both cyclooxygenase and lipoxygenase catalyzed pathways, and has been used extensively to study the effect of inhibitors of phospholipases, cyclooxygenase and lipoxygenase enzymes.
Negative_regulation (inhibitors) of lipoxygenase in macrophage associated with inflammation
20) Confidence 0.20 Published 1989 Journal Medicina (B Aires) Section Abstract Doc Link 2640487 Disease Relevance 0.25 Pain Relevance 0.27

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