INT174230

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.20
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12B) extracellular region (IL12B) cytoplasm (IL12B)
Anatomy Link Frequency
lung 4
macrophages 2
B lymphocytes 2
T-cell 2
IL12B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 119 100.00 Very High Very High Very High
agonist 10 100.00 Very High Very High Very High
chemokine 23 99.08 Very High Very High Very High
tolerance 1 94.40 High High
Inflammation 44 91.00 High High
rheumatoid arthritis 63 82.32 Quite High
antagonist 2 81.68 Quite High
anakinra 1 80.80 Quite High
Arthritis 83 74.48 Quite High
abatacept 2 67.20 Quite High
Disease Link Frequency Relevance Heat
Cold Sores 36 97.98 Very High Very High Very High
Reprotox - General 1 5 97.54 Very High Very High Very High
Critical Illness 74 94.60 High High
Glioblastoma 4 92.64 High High
Cancer 64 91.24 High High
INFLAMMATION 53 91.00 High High
Rheumatoid Arthritis 63 82.32 Quite High
Disease 66 76.68 Quite High
Necrosis 5 74.52 Quite High
Juvenile Chronic Polyarthritis 73 74.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
are induced by murine macrophages in response to both TLR-2 and TLR-4 agonists, however, iNOS, IL-12p40, IP-10 and MCP-5 are produced primarily in response to TLR-4 agonists [130,131].
Positive_regulation (induced) of Gene_expression (produced) of IL-12p40 in macrophages associated with agonist
1) Confidence 0.49 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.32 Pain Relevance 0.60
Comparison of lung cytokines and chemokines at protein and gene levels showed comparable elevated levels of IL12B, CXCL8, IL1B, CCL3, IL1A and IL6 while IL17, TNF and IL10 were elevated only at the gene level.
Positive_regulation (elevated) of Gene_expression (levels) of IL12B in lung associated with chemokine and cytokine
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.55 Pain Relevance 0.14
Comparison of lung cytokines and chemokines at protein and gene levels showed comparable elevated levels of IL12B, CXCL8, IL1B, CCL3, IL1A and IL6 while IL17, TNF and IL10 were elevated only at the gene level.
Positive_regulation (elevated) of Gene_expression (levels) of IL12B in lung associated with chemokine and cytokine
3) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.56 Pain Relevance 0.14
Some that are currently in development and at the trial stages are agents targeting IL-1, cytokines from the TNF superfamily, IL-15, IL-17, B lymphocytes, IL-12/IL-23, SyK kinase, JAK3 kinase, and inhibitors of osteoclastogenesis.40–51

Chemistry and mechanism of action

Positive_regulation (targeting) of Gene_expression (/) of IL-12 in B lymphocytes associated with cytokine
4) Confidence 0.08 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.41 Pain Relevance 0.45
The median levels of IL2, IL4, IL5, IL12, and IFN?
Positive_regulation (median) of Gene_expression (levels) of IL12
5) Confidence 0.05 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 0.28 Pain Relevance 0.22
A TH1-based immune response was seen in rat prostate cancer models undergoing HSV-Tk/GCV therapy [15], and a clinical study also showed elevated numbers of peripheral T and B cells, enhanced T-cell activation, and elevated serum levels of interleukin 12 during intracranial GCV treatment

[16].

Positive_regulation (enhanced) of Gene_expression (levels) of interleukin 12 in T-cell associated with cold sores and reprotox - general 1
6) Confidence 0.01 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 1.06 Pain Relevance 0

General Comments

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