INT174235

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 0.63
Pain Relevance 0

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endoplasmic reticulum (CES2) catabolic process (CES2)
Anatomy Link Frequency
liver 1
CES2 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 4 33.40 Quite Low
Glutamate 10 10.08 Low Low
cocaine 5 5.00 Very Low Very Low Very Low
lidocaine 5 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 64 98.88 Very High Very High Very High
Neuroblastoma 2 87.52 High High
Cytomegalovirus Infection 1 84.56 Quite High
Adenocarcinoma 3 81.64 Quite High
Suicidal Behaviour 7 50.00 Quite Low
Breast Cancer 8 13.08 Low Low
Cold Sores 36 5.00 Very Low Very Low Very Low
Glioma 18 5.00 Very Low Very Low Very Low
Colon Cancer 16 5.00 Very Low Very Low Very Low
Ovarian Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein sequences were generated in silico for opossum CES genes using the UC Santa Cruz Genome Browser [38,39] and human CES1, CES2 and CES6 sequences in BLAT analyses of the opossum genome.
Spec (analyses) Positive_regulation (generated) of CES2
1) Confidence 0.50 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
The following UniProtKB/Swiss-Prot Database sequences were used to interrogate the opossum genome sequence [38]: human sequences CES1 (P23141), CES2 (O00748), CES3 (Q6UWW8), CES4 (Q8TDZ9); CES6 (Q6UX55) and CES7 (Q96DN9) (Table 1); as well as the opossum CES2 sequence reported in this paper.
Positive_regulation (sequences) of CES2
2) Confidence 0.50 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
The deduced amino acid sequence for opossum CES2.1 is shown in Figure 2 with the previously reported sequence for human CES2 [18,19], together with the predicted protein sequences for opossum CES2.2 and CES2.3.
Positive_regulation (opossum) of CES2.2
3) Confidence 0.44 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
The deduced amino acid sequence for opossum CES2.1 is shown in Figure 2 with the previously reported sequence for human CES2 [18,19], together with the predicted protein sequences for opossum CES2.2 and CES2.3.
Positive_regulation (sequence) of CES2
4) Confidence 0.44 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
The deduced amino acid sequence for opossum CES2.1 is shown in Figure 2 with the previously reported sequence for human CES2 [18,19], together with the predicted protein sequences for opossum CES2.2 and CES2.3.
Positive_regulation (opossum) of CES2
5) Confidence 0.19 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
A panel of human tumor cell lines transduced with rabbit liver CE showed high levels of CE activity, and were
Positive_regulation (levels) of CE in liver associated with cancer
6) Confidence 0.01 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 0.63 Pain Relevance 0

General Comments

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