INT174239

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Context Info
Confidence 0.65
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.25
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2C18) endoplasmic reticulum (CYP2C18)
Anatomy Link Frequency
endothelial cells 1
CPA 1
CYP2C18 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 1 99.72 Very High Very High Very High
Nicotine 5 99.28 Very High Very High Very High
tolerance 1 83.96 Quite High
Lasting pain 6 82.84 Quite High
Inflammation 34 80.64 Quite High
Paracetamol 5 72.96 Quite High
Pain 13 69.76 Quite High
antidepressant 1 61.88 Quite High
cINOD 3 57.92 Quite High
antagonist 14 45.84 Quite Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 76 99.72 Very High Very High Very High
Targeted Disruption 11 95.16 Very High Very High Very High
Glioma 19 92.76 High High
Cancer 179 84.40 Quite High
Pain 20 82.84 Quite High
INFLAMMATION 36 80.64 Quite High
Anxiety Disorder 2 79.60 Quite High
Occupational Lung Diseases 1 78.44 Quite High
Colon Cancer 16 65.76 Quite High
Body Weight 10 60.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inserted human CYP2C18 and CYP2C19 genes are expressed at the mRNA and protein levels, and the inserted CYP2C19 genes have been shown to be functional in vitro in metabolism studies using the CYP2C19 substrates S-mephenytoin and R-omeprazole)[21].
Gene_expression (expressed) of CYP2C18
1) Confidence 0.65 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2607276 Disease Relevance 0.27 Pain Relevance 0.03
To our knowledge, the present study is the first to verify whether, as suggested by Jensen et al. [2], the scales making up the CPCI are grouped into families of coping with the use of confirmatory factorial analysis.
Gene_expression (making) of CPCI
2) Confidence 0.57 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1386669 Disease Relevance 0.23 Pain Relevance 0.15
Expression of CYP1A2, CYP2C8, CYP2C18, CYP2C19, CYP2D6, CYP3A7, CYP4A11, FMO1, and FMO3 was below the limit of detection (LOD) in all investigated samples (data not shown).


Spec (investigated) Gene_expression (Expression) of CYP2C18
3) Confidence 0.53 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.49 Pain Relevance 0
CYP2C subfamily: is one of the most important families and consists primarily of two enzymes, CYP2C9 and CYP2C19.
Gene_expression (one) of CYP2C
4) Confidence 0.22 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2584094 Disease Relevance 0.60 Pain Relevance 0.38
EETs are primarily synthesized in endothelial cells which express isoforms of CYP2C and CYP2J (e.g., CYP2C9 and CYP2J2) [10, 34–37].
Gene_expression (express) of CYP2C in endothelial cells
5) Confidence 0.14 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 0.20 Pain Relevance 0.08
Greatest sensitization to CPA was seen with CYP2B6, but CYP2C18-Met was also effective, despite a very low level of CYP protein expression (> 60-fold lower than that of 2B6), with substantial further increases upon additional transduction with NADH P450 reductase.
Gene_expression (effective) of CYP2C18-Met in CPA
6) Confidence 0.04 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 0.46 Pain Relevance 0

General Comments

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