INT174240

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 6.35
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TYMS) mitochondrion (TYMS) small molecule metabolic process (TYMS)
aging (TYMS) cytoplasm (TYMS) cytosol (TYMS)
TYMS (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 130 99.56 Very High Very High Very High
methotrexate 47 97.76 Very High Very High Very High
adenocard 7 95.12 Very High Very High Very High
Glutamate 14 87.84 High High
Inflammation 20 79.60 Quite High
drug abuse 57 77.68 Quite High
palliative 8 71.36 Quite High
peripheral neuropathy 4 63.36 Quite High
cINOD 6 62.08 Quite High
rheumatoid arthritis 65 59.92 Quite High
Disease Link Frequency Relevance Heat
Cancer 323 97.60 Very High Very High Very High
Colon Cancer 63 97.28 Very High Very High Very High
Cold Sores 72 97.20 Very High Very High Very High
Apoptosis 43 96.92 Very High Very High Very High
Sprains And Strains 22 95.44 Very High Very High Very High
Glioma 38 95.28 Very High Very High Very High
Metastasis 12 90.68 High High
Disease 68 89.28 High High
Small Cell Lung Cancer 63 88.48 High High
Leukemia 3 86.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Within the cell, the drug inhibits thymidylate synthetase during the S phase of the cell cycle, preventing DNA and RNA synthesis in rapidly dividing cells because of a lack of thymidine.
Negative_regulation (inhibits) of thymidylate synthetase
1) Confidence 0.57 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2694026 Disease Relevance 0.33 Pain Relevance 0
Despite extensive studies of the drug's mechanism of action in fungal [17], fly [18] and human [16] systems, this information was nearly, but not entirely, forgotten [19] as investigators focused on the potential for 5-fluorouracil to function as a pro-drug of 5-fluoro-dUMP, a potent inhibitor of thymidylate synthetase [20].
Negative_regulation (inhibitor) of thymidylate synthetase
2) Confidence 0.42 Published 2004 Journal Genome Biol Section Body Doc Link PMC522863 Disease Relevance 0.53 Pain Relevance 0
A reduced level of TS mRNA might also lead to a lower TS protein expression, and make tumors more sensitive to 5-FU based chemotherapy [13,36,37].
Negative_regulation (reduced) of TS mRNA associated with cancer
3) Confidence 0.25 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2442115 Disease Relevance 0.37 Pain Relevance 0.03
The antitumor effect of 5-FU has ascribed to the competitive inhibition of thymidylate synthase (TS) [10].
Negative_regulation (inhibition) of thymidylate synthase
4) Confidence 0.25 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2442115 Disease Relevance 0.52 Pain Relevance 0.07
This deletion may be associated with decreased TYMS mRNA stability and expression [72], thereby increasing MTX efficacy [66].
Negative_regulation (decreased) of TYMS associated with methotrexate
5) Confidence 0.24 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691664 Disease Relevance 0.27 Pain Relevance 0.45
Lower levels of pemetrexed (Eli Lilly and Company, Indianapolis, IN, USA) inhibit thymidylate synthase and dihydrofolate reductase, while higher levels inhibit glycinamide ribonucleotide formyltransferase, inhibiting purine synthesis (Hazarika et al 2005).
Negative_regulation (inhibit) of thymidylate synthase
6) Confidence 0.13 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503655 Disease Relevance 0.17 Pain Relevance 0.06
For example, the pentaglutamatation of pemetrexed increases its ability to inhibit thymidylate synthase 84-fold (Curtin and Hughes 2001).


Negative_regulation (inhibit) of thymidylate synthase
7) Confidence 0.13 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503655 Disease Relevance 0.15 Pain Relevance 0.20
TYMS, C5orf3, PTRF and KLF5 were decreased in Groups I–II and increased in Group III.
Negative_regulation (decreased) of TYMS
8) Confidence 0.09 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.14 Pain Relevance 0.09
We found that the anti-proliferative activity of capsaicin is correlated with a decrease in the expression of E2F-responsive proliferative genes like cyclin E, thymidylate synthase, cdc25A and cdc6, both at mRNA and protein levels.
Negative_regulation (decrease) of thymidylate synthase associated with qutenza
9) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2857654 Disease Relevance 0.67 Pain Relevance 0.91
BVDU exerts its cytotoxic effect not only by incorporation into replicating DNA, but also through inhibition of thymidylate synthase.
Negative_regulation (inhibition) of thymidylate synthase
10) Confidence 0.06 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 0.76 Pain Relevance 0
Intracellular metabolites of 5-FU can exert cytotoxic effects via inhibition of thymidylate synthetase, or through incorporation into RNA and DNA, events that ultimately activate apoptosis [2].
Negative_regulation (inhibition) of thymidylate synthetase associated with apoptosis
11) Confidence 0.06 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.90 Pain Relevance 0
Cells expressing both enzymes showed large increases in 5-FdUMP, 5-fluorouridine triphosphate, incorporation into RNA and inhibition of thymidylate synthase [66].
Negative_regulation (inhibition) of thymidylate synthase
12) Confidence 0.04 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 1.53 Pain Relevance 0

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