INT174242

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.54
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP4B1) endoplasmic reticulum (CYP4B1)
CYP4B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 54 99.52 Very High Very High Very High
cINOD 80 98.12 Very High Very High Very High
Paracetamol 4 85.00 Quite High
Inflammatory response 2 83.76 Quite High
aspirin 2 82.60 Quite High
corticosteroid 9 75.04 Quite High
COX2 11 60.44 Quite High
cOX1 9 41.88 Quite Low
Glutamate 5 19.68 Low Low
Potency 5 18.40 Low Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 136 99.76 Very High Very High Very High
Glioma 18 99.76 Very High Very High Very High
INFLAMMATION 57 99.52 Very High Very High Very High
Breast Cancer 8 84.16 Quite High
Colon Cancer 16 82.40 Quite High
Ovarian Cancer 6 81.00 Quite High
Cancer 61 80.88 Quite High
Injury 11 80.76 Quite High
Hypoxia 9 79.80 Quite High
Ocular & Orbital Inflammation 3 72.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, CYP4B1 was detected in 5 smokers and 1 nonsmoker, and CYP3A4 was detected in 2 nonsmokers but was < LOD in smokers (data not shown).


Gene_expression (detected) of CYP4B1 associated with nicotine addiction
1) Confidence 0.49 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.84 Pain Relevance 0
Expression of CYP2B6/7, CYP2E1, CYP2F1, CYP2S1, CYP4B1, and FMO5 was similar to that of nonsmokers.
Gene_expression (Expression) of CYP4B1
2) Confidence 0.49 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.78 Pain Relevance 0
NSAIDs may also potentiate peroximase proliferator-activated receptors with subsequent induction of CYP4B1 activity and production of the pro-inflammatory compounds 12-HETE and 12-HETrE.
Gene_expression (production) of CYP4B1 associated with inflammation and cinod
3) Confidence 0.32 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693998 Disease Relevance 1.25 Pain Relevance 1.01
Both rat (9L) and human (U87) glioma cell lines transduced with rabbit CYP4B1 were sensitized about 20 fold to 4-IM (IC50s about 2.5??
Gene_expression (transduced) of CYP4B1 associated with glioma
4) Confidence 0.24 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 0.68 Pain Relevance 0.31

General Comments

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